Modulation of cis-dichlorodiammineplatinum(II)-induced cytotoxicity by benzaldehyde derivatives.

abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...

journal_title：Cancer letters

authors： Xu W,Chen GS,Shao Y,Li XL,Xu HC,Zhang H,Zhu GQ,Zhou YC,He XP,Sun WH

更新日期：2013-05-10 00:00:00

abstract：:Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in vivo. The nuclear factor-kappa B (NF-kappaB) plays an important role in tumor cell growth, proliferation, invasion, and survival. In this study, we investigated the effects and the molecular mechanisms of gossypol on NF-kappaB ...

journal_title：Cancer letters

authors： Moon DO,Kim MO,Lee JD,Kim GY

更新日期：2008-06-18 00:00:00

abstract：:The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications...

journal_title：Cancer letters

authors： Zhang J,Shen L,Sun LQ

更新日期：2015-07-28 00:00:00

abstract：:We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription fa...

journal_title：Cancer letters

authors： Eckerle I,Muth D,Batzler J,Henrich KO,Lutz W,Fischer M,Witt O,Schwab M,Westermann F

更新日期：2009-11-18 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...

journal_title：Cancer letters

authors： He Z,Wu J,Dang H,Lin H,Zheng H,Zhong D

更新日期：2011-04-28 00:00:00

abstract：:Glucocorticoids (GCs) are pro-apoptotic as a co-medication to treat leukemia and lymphoma. However, the effects in breast cancer (BC) are diverse with mechanisms less understood. In this study using BC model cell MCF7, we found that dexamethasone (Dex) promotes cell proliferation. Gene expression analysis identified t...

journal_title：Cancer letters

authors： Khan S,Lopez-Dee Z,Kumar R,Ling J

更新日期：2013-08-28 00:00:00

abstract：:Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...

journal_title：Cancer letters

authors： Moan J,Christensen T

更新日期：1979-05-01 00:00:00

abstract：:As a third-generation platinum drug, oxaliplatin has been widely applied in colorectal cancer (CRC); however, acquired resistance to oxaliplatin has become a major obstacle. In the present study, we found that the nuclear transcription factor Y subunit beta (NFYB) and E2F transcription factor 1 (E2F1) expression level...

journal_title：Cancer letters

authors： Fang Z,Gong C,Yu S,Zhou W,Hassan W,Li H,Wang X,Hu Y,Gu K,Chen X,Hong B,Bao Y,Chen X,Zhang X,Liu H

更新日期：2018-02-28 00:00:00

abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

journal_title：Cancer letters

authors： Fabbro M,Henderson BR

更新日期：2008-05-18 00:00:00

abstract：:Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...

journal_title：Cancer letters

authors： Castañón E,Soltermann A,López I,Román M,Ecay M,Collantes M,Redrado M,Baraibar I,López-Picazo JM,Rolfo C,Vidal-Vanaclocha F,Raez L,Weder W,Calvo A,Gil-Bazo I

更新日期：2017-08-28 00:00:00

abstract：:The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyper...

journal_title：Cancer letters

authors： Iida K,Yamamoto M,Kato M,Yoshida K,Kurita K,Tatematsu M

更新日期：1999-01-29 00:00:00

abstract：:During a follow-up program, breast cancer patients were monitored with serum analyses of mucin-like carcinoma-associated antigen (MCA), CA 15.3 and carcinoembryonic antigen (CEA). Minimum as well as maximum marker values of the individual patterns were selected for further evaluation. Marker levels of risk patients di...

journal_title：Cancer letters

authors： Bieglmayer C,Szepesi T,Neunteufel W

更新日期：1988-11-01 00:00:00

abstract：:Indomethacin is a non-steroidal anti-inflammatory agent that inhibits prostaglandin synthesis. Administration of indomethacin, in doses which were non-toxic to normal BALB/c mice, to mice bearing the BCL1 leukemia resulted in increased mortality of these animals. This effect was only observed if the indomethacin was a...

journal_title：Cancer letters

authors： Hart DA

更新日期：1984-06-01 00:00:00

abstract：:We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras on...

journal_title：Cancer letters

authors： Sato N,Mizumoto K,Beppu K,Maehara N,Kusumoto M,Nabae T,Morisaki T,Katano M,Tanaka M

更新日期：2000-07-31 00:00:00

abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...

journal_title：Cancer letters

authors： Cervenak J,Andrikovics H,Ozvegy-Laczka C,Tordai A,Német K,Váradi A,Sarkadi B

更新日期：2006-03-08 00:00:00

abstract：:The inactivation mechanisms and functional role of p16INK4a in three Asian esophageal squamous cell carcinoma (ESCC) cell lines were investigated by polymerase chain reaction (PCR) amplification, DNA sequencing, methylation-specific PCR analysis, reverse transcription-PCR, Western blotting, and colony formation assays...

journal_title：Cancer letters

authors： Kwong FM,Tang JC,Srivastava G,Lung ML

更新日期：2004-05-28 00:00:00

abstract：:Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...

journal_title：Cancer letters

authors： Beerepoot LV,Mehra N,Linschoten F,Jorna AS,Lisman T,Verheul HM,Voest EE

更新日期：2004-09-30 00:00:00

abstract：:An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). Therefore, an active principle of the extract, the furanoheliangolide sesquiterpene lactone lobatin B, was isolated and te...

journal_title：Cancer letters

authors： Kiss I,Unger C,Huu CN,Atanasov AG,Kramer N,Chatruphonprasert W,Brenner S,McKinnon R,Peschel A,Vasas A,Lajter I,Kain R,Saiko P,Szekeres T,Kenner L,Hassler MR,Diaz R,Frisch R,Dirsch VM,Jäger W,de Martin R,Bochkov

更新日期：2015-01-28 00:00:00

abstract：:Mutations in the ERK pathway occur in approximately one-third of all human cancers and most often involve production of mutant RAS or BRAF. Several studies, including our own, have shown that mutations in the BRAF and RAS genes are generally mutually exclusive. This study was performed to determine the relative oncoge...

journal_title：Cancer letters

authors： Benjamin CL,Ananthaswamy HN

更新日期：2008-03-18 00:00:00

abstract：:Despite the significance of tumor angiogenesis and the extensive knowledge on the molecular basis of blood vessel formation in carcinoma of colorectum, no data exist in hyperplastic polyp. This prompted us to examine angiogenesis in hyperplastic polyp. Eleven small hyperplastic polyps, 13 large hyperplastic polyps and...

journal_title：Cancer letters

authors： Sano Y,Maeda N,Kanzaki A,Fujii T,Ochiai A,Takenoshita S,Takebayashi Y

更新日期：2005-02-10 00:00:00

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...

journal_title：Cancer letters

authors： Li CJ,Chu CY,Huang LH,Wang MH,Sheu LF,Yeh JI,Hsu HY

更新日期：2012-06-28 00:00:00

abstract：:To obtain an optimal condition for ultrasound (US)-induced apoptosis that could be useful for cancer therapy, we applied low intensity pulsed US to sonicate U937 cells in vitro. Cells were then incubated at different time intervals before measuring apoptosis. The apoptosis was assessed by DNA fragmentation and phospha...

journal_title：Cancer letters

authors： Feril LB Jr,Kondo T,Cui ZG,Tabuchi Y,Zhao QL,Ando H,Misaki T,Yoshikawa H,Umemura S

更新日期：2005-04-28 00:00:00

abstract：:The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

journal_title：Cancer letters

authors： Paredes F,Williams HC,San Martin A

更新日期：2021-01-11 00:00:00

abstract：:BEC, a standard mixture of solasodine glycosides is effective in vivo against murine sarcoma 180 (S180), whereas the aglycone solasodine at equimolar concentrations is ineffective. The efficacy of BEC against S180 in vivo can be inhibited by rhamnose. Mice which are in their terminal stage with S180 can tolerate and b...

journal_title：Cancer letters

authors： Cham BE,Daunter B

更新日期：1990-12-17 00:00:00

abstract：:In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These proteins act as molecular chaperones by assisting proper folding and refolding of misfolded proteins and aid in the elimination of old and damaged cells. HSPs include Hsp100, Hsp90, Hsp70, Hsp40, and small HSPs. Through its substrate...

journal_title：Cancer letters

authors： Kumar S,Stokes J 3rd,Singh UP,Scissum Gunn K,Acharya A,Manne U,Mishra M

更新日期：2016-04-28 00:00:00

abstract：:Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on STAT3 activation, associated pro...

journal_title：Cancer letters

authors： Lee JH,Kim C,Kim SH,Sethi G,Ahn KS

更新日期：2015-05-01 00:00:00

abstract：:We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...

journal_title：Cancer letters

authors： Nakamura Y,Morimitsu Y,Uzu T,Ohigashi H,Murakami A,Naito Y,Nakagawa Y,Osawa T,Uchida K

更新日期：2000-09-01 00:00:00

abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

journal_title：Cancer letters

authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

更新日期：2016-05-01 00:00:00

abstract：:Endostatin has been demonstrated to represent a promising novel medicine to treat malignant tumors, and it may be more effective when combined with conventional treatment. Meanwhile, a promising area of research in radiation oncology is the integration of molecular targeting agents to improve the effectiveness of radi...

journal_title：Cancer letters

authors： Zhuang HQ,Yuan ZY

更新日期：2009-09-08 00:00:00