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Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential.

Abstract：

:We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras oncogene. Of particular interest, the cells express markedly elevated mRNA levels of angiogenic factors, vascular endothelial growth factor and platelet-derived growth factor, as well as other tumor growth-related factors. Subcutaneous transplantation of the NOR-P1 cells into nude mice formed solid, hemorrhagic tumors which were histologically diagnosed as adenocarcinoma with dense blood vessels and severe extravasation of blood. Furthermore, when NOR-P1 cell suspension was injected directly into the pancreas of nude mice, the cells grew rapidly to form intra-pancreatic tumors associated with liver metastases and peritoneal dissemination that resulted in cachexia and subsequent death. These properties suggest that NOR-P1 is an aggressive pancreatic cancer cell line with a high metastatic potential and may serve as a useful experimental model for studying tumor angiogenesis and metastasis of pancreatic cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Sato N,Mizumoto K,Beppu K,Maehara N,Kusumoto M,Nabae T,Morisaki T,Katano M,Tanaka M

doi

10.1016/s0304-3835(00)00421-3

keywords:

subject

Has Abstract

pub_date

2000-07-31 00:00:00

pages

153-61

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383500004213

journal_volume

155

pub_type

杂志文章

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