Abstract:
:HIV protease inhibitors (HIV-PIs) are a class of antiretroviral drugs designed to target the viral protease. Strikingly, these drugs have also been reported to possess antitumor effect. In this study, we evaluated the activity of one HIV-PI, Nelfinavir, against human cervical cancer cells. We found that Nelfinavir inhibited the growth of cervical cancer cell lines at the lowest micromolar concentrations clinically attainable. Nelfinavir promoted apoptosis and arrested the cell cycle at G1 phase. Apoptosis is attributed to the promotion of mitochondrial reactive oxygen species (ROS) production, which results in the translocation of mitochondrial apoptosis inducing factor (AIF) to the nucleus. We further showed that Nelfinavir increased mitochondrial ROS production by decreasing manganese superoxide dismutase (MnSOD) protein levels. Taken together, our results suggest that Nelfinavir can be repositioned as a cervical cancer therapeutic.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Xiang T,Du L,Pham P,Zhu B,Jiang Sdoi
10.1016/j.canlet.2015.04.027subject
Has Abstractpub_date
2015-08-01 00:00:00pages
79-88issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(15)00306-7journal_volume
364pub_type
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