Abstract:
:The present study was conducted to investigate protein levels of inducible NO synthase (iNOS) and cayclooxygenase-2 (COX-2) in human colon cancer tissues. Significant increase of iNOS and COX-2 levels in tumors as compared to paired normal tissue was observed in 15 and 28, respectively, of 29 cases investigated. No correlation was observed between the two enzymes, and immunohistochemically demonstrated iNOS expression was mainly observed in tumor epithelial cells and was higher in well-differentiated than moderately-differentiated adenocarcinomas, while COX-2 expression was mainly detected in stromal cells and higher in Dukes' C and D than Dukes' A and B cases. These results suggest that iNOS and COX-2 have separate roles in colon carcinogenesis, and might both be usefully targeted by chemoprevention.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ohta T,Takahashi M,Ochiai Adoi
10.1016/j.canlet.2005.08.014keywords:
subject
Has Abstractpub_date
2006-08-08 00:00:00pages
246-53issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00765-2journal_volume
239pub_type
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