Abstract:
:The intracellular androgen metabolism and cell activity in prostate cancer cells with mutated (LNCaP-FGC) or wild-type (VCaP) androgen receptors in the presence of trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, were examined. Trilostane suppressed the intracellular production of androstenedione, testosterone, and dihydrotestosterone from dehydroepiandrosterone in LNCaP-FGC cells. In both LNCaP-FGC and VCaP cell types, the prostate-specific antigen (PSA) levels in media were increased by trilostane alone in a concentration-dependent manner. Both cells pretreated with trilostane showed a dose-dependent decrease in PSA production with bicalutamide (P<0.001). Trilostane should be used with particular concern when treating prostate cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Takizawa I,Nishiyama T,Hara N,Hoshii T,Ishizaki F,Miyashiro Y,Takahashi Kdoi
10.1016/j.canlet.2010.05.015subject
Has Abstractpub_date
2010-11-28 00:00:00pages
226-30issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00304-6journal_volume
297pub_type
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