HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma: study of 205 Italian subjects.

abstract：:Twenty-seven patients with malignant teratoma, 19 of which received radiation, are presented and the radiation response analyzed. Radiotherapy seems most effective in the palliation of undifferentiated (embryonal) teratoma of the gonads and sacrococcygeal region in early childhood. It is less effective, yet useful, in...

journal_title：Cancer letters

authors： Pantoja E,Roswit B

更新日期：1975-11-01 00:00:00

abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...

journal_title：Cancer letters

authors： Tang MK,Wong AS

更新日期：2015-10-10 00:00:00

abstract：:Radiofrequency ablation (RFA) is widely accepted as a first-line interventional oncology approach for hepatocellular carcinoma (HCC) and has the advantages of high treatment efficacy and low complication risk. Local control rates equivalent to hepatic resection can be reached by RFA alone when treating small HCCs (<2 ...

journal_title：Cancer letters

authors： Chen L,Sun J,Yang X

更新日期：2016-01-01 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00

abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

journal_title：Cancer letters

authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

更新日期：2002-12-10 00:00:00

abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

journal_title：Cancer letters

authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

更新日期：2016-05-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...

journal_title：Cancer letters

authors： Half E,Sun Y,Sinicrope FA

更新日期：2007-06-28 00:00:00

abstract：:The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 ham...

journal_title：Cancer letters

authors： Nishikawa A,Furukawa F,Kasahara K,Tanakamaru Z,Miyauchi M,Nakamura H,Ikeda T,Imazawa T,Hirose M

更新日期：1999-07-01 00:00:00

abstract：:The modifying effects of nonylphenol and genistein on cancer induction were assessed in a multi-organ carcinogenesis model in male F344 rats initially treated with five different carcinogens. In experiment 1 rats received 250 or 25 ppm nonylphenol, or 250 or 25 ppm genistein in their diet for 28 weeks. The total incid...

journal_title：Cancer letters

authors： Seike N,Wanibuchi H,Morimura K,Wei M,Nishikawa T,Hirata K,Yoshikawa J,Fukushima S

更新日期：2003-03-20 00:00:00

abstract：:The chemokine CXCL12 (SDF-1) and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies. Head and neck squamous cell carcinoma (HNSCC) predominantly metastasizes to lymph nodes, and recent evidence has shown that CXCL12 stimulates HNSCC migration. We explored the potential role ...

journal_title：Cancer letters

authors： Samara GJ,Lawrence DM,Chiarelli CJ,Valentino MD,Lyubsky S,Zucker S,Vaday GG

更新日期：2004-10-28 00:00:00

abstract：:We have examined the effect of protease inhibitors on radiation-induced DNA amplification in vitro using an SV40-transformed Chinese hamster embryo cell line. DNA from cells irradiated with X-rays (10 Gy) or ultraviolet radiation (8 J/m2) resulted in an 8-fold or greater amplification of SV40 sequences compared with u...

journal_title：Cancer letters

authors： Flick MB,Kennedy AR

更新日期：1991-02-01 00:00:00

abstract：:We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...

journal_title：Cancer letters

authors： Nakamura Y,Morimitsu Y,Uzu T,Ohigashi H,Murakami A,Naito Y,Nakagawa Y,Osawa T,Uchida K

更新日期：2000-09-01 00:00:00

abstract：:The immunomodulatory and antimetastatic/antitumor activity of thymosin alpha(1) (Talpha(1)) was evaluated in BALB/c-mice. Daily subcutaneous application (7 consecutive days, 0.01-10 microg of Talpha(1)/injection per mouse) upregulated the number of thymocytes and peripheral blood cells in tumor bearing mice. To check ...

journal_title：Cancer letters

authors： Beuth J,Schierholz JM,Mayer G

更新日期：2000-10-16 00:00:00

abstract：:The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...

journal_title：Cancer letters

authors： Schillert A,Trumpp A,Sprick MR

更新日期：2013-11-28 00:00:00

abstract：:The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary thyroid carcinoma (PTC) tissue. Additionally, the expression of dC...

journal_title：Cancer letters

authors： Karbownik M,Brzezianska E,Lewinski A

更新日期：2005-07-28 00:00:00

abstract：:Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...

journal_title：Cancer letters

authors： Jeong SJ,Itokawa T,Shibuya M,Kuwano M,Ono M,Higuchi R,Miyamoto T

更新日期：2002-12-10 00:00:00

abstract：:The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlate...

journal_title：Cancer letters

authors： Siboni G,Amit-Patito I,Weizman E,Waintraub-Porat M,Weitman H,Ehrenberg B,Malik Z

更新日期：2003-06-30 00:00:00

abstract：:Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory ...

journal_title：Cancer letters

authors： Jiang D,Chen S,Sun R,Zhang X,Wang D

更新日期：2018-04-10 00:00:00

abstract：:We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of...

journal_title：Cancer letters

authors： Gao H,Peng C,Liang B,Shahbaz M,Liu S,Wang B,Sun Q,Niu Z,Niu W,Liu E,Wang J,Lin P,Wang J,Niu J

更新日期：2014-11-28 00:00:00

abstract：:MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

journal_title：Cancer letters

authors： Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

更新日期：2009-02-18 00:00:00

abstract：:Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the ...

journal_title：Cancer letters

authors： Das A,Tan WL,Smith DR

更新日期：2003-04-25 00:00:00

abstract：:The malignant phenotype results from multiple genetic alterations, including the activation of oncogenes and inactivation of tumor suppressor genes. Activation of the Ki-ras oncogene has been implicated as an early event in the pathogenesis of lung adenocarcinomas in humans and experimental animal models. Previous stu...

journal_title：Cancer letters

authors： Mizesko MC,Grewe C,Grabner A,Miller MS

更新日期：2001-10-22 00:00:00

abstract：:Well differentiated thyroid carcinomas provide a unique model of human, epithelial cell carcinogenesis. Their molecular characterization has allowed to associate specific genetic alterations to the two papillary and follicular histotypes which, despite their common origin, display different biological and clinical beh...

journal_title：Cancer letters

authors： Pierotti MA

更新日期：2001-05-10 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...

journal_title：Cancer letters

authors： Baghdiguian S,Boudier JA,Boudier JL,Fantini J

更新日期：1993-12-20 00:00:00

abstract：:Circulating free DNA (CFDNA) has been shown to be a good source of liver tissue-derived DNA in African and Asian patients with chronic liver disease or HCC. In Egypt, HCC is a frequent carcinoma and mostly occur in the context of chronic infection by HCV, a widespread infection in the Egyptian population. Here we have...

journal_title：Cancer letters

authors： Hosny G,Farahat N,Tayel H,Hainaut P

更新日期：2008-06-18 00:00:00

abstract：:Here we found that dual mTORC1/2 inhibitor AZD-2014 significantly inhibited RCC cell survival and growth, with higher efficiency than conventional mTORC1 inhibitors rapamycin and RAD001. RCC cell apoptosis was also induced by AZD-2014. AZD-2014 disrupted mTORC1/2 assembly and activation, while downregulating HIF-1α/2α...

journal_title：Cancer letters

authors： Zheng B,Mao JH,Qian L,Zhu H,Gu DH,Pan XD,Yi F,Ji DM

更新日期：2015-02-28 00:00:00

abstract：:In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein--Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji ...

journal_title：Cancer letters

authors： Itoigawa M,Ito C,Tan HT,Kuchide M,Tokuda H,Nishino H,Furukawa H

更新日期：2001-08-10 00:00:00

abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

journal_title：Cancer letters

authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

更新日期：2016-12-28 00:00:00

abstract：:Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...

journal_title：Cancer letters

authors： Beniashvili DS,Bilanishvili VG,Menabde MZ

更新日期：1991-12-09 00:00:00