Abstract:
:Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the apoptotic process, namely bax and bcl2. Survivin expression was noted in 94% (85/90) of samples and was not correlated with the expression of either bax or bcl2 or with clinicopathological factors.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Das A,Tan WL,Smith DRdoi
10.1016/s0304-3835(02)00741-3keywords:
subject
Has Abstractpub_date
2003-04-25 00:00:00pages
217-23issue
2eissn
0304-3835issn
1872-7980pii
S0304383502007413journal_volume
193pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.032
更新日期:2016-05-01 00:00:00
abstract::Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.08.008
更新日期:2010-12-28 00:00:00
abstract::CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD13...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.09.009
更新日期:2018-12-01 00:00:00
abstract::We studied the effect of staurosporine (SSP), a broad-spectrum protein kinase inhibitor, on the levels of protein kinase C (PKC) activity and proliferation in two murine neuroblastoma cell lines, Neuro2a and its clone NB41A3. The PKC activity was examined in whole cell lysate, cytosolic and particulate fractions. A di...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00021-x
更新日期:1999-05-24 00:00:00
abstract::Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90147-3
更新日期:1994-07-15 00:00:00
abstract::The exact role of mast cells in tumor growth is not clear and multifaceted. In some cases, mast cells stimulate while in others inhibit this process. This dual role may be explained to some extent by the huge number of bioactive molecules stored in mast cell granules, as well as differences between tumor microenvironm...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.07.005
更新日期:2018-10-01 00:00:00
abstract::Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90090-6
更新日期:1994-03-15 00:00:00
abstract::In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inh...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90097-s
更新日期:1993-07-30 00:00:00
abstract::Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.008
更新日期:2015-01-28 00:00:00
abstract::Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90023-5
更新日期:1979-11-01 00:00:00
abstract::Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimuri...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90254-u
更新日期:1990-07-16 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the risk of colorectal cancer (CRC). They are also known to induce the regression of colorectal adenomas, which are precursors to CRC. Despite these evidences, the exact mechanism by which NSAIDs exerts its anti-oncogenic effect is not completely...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00716-9
更新日期:2002-01-10 00:00:00
abstract::Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.09.019
更新日期:2008-01-18 00:00:00
abstract::Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells me...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.05.028
更新日期:2008-11-08 00:00:00
abstract::Certain polyunsaturated fatty acids can selectively kill tumor cell lines while causing little to no harm to normal cell lines. However, the mechanism of this cytotoxicity is only partially understood. Antioxidants such as vitamin E have been shown to be capable of completely blocking the cytotoxic response when admin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:
更新日期:1996-01-02 00:00:00
abstract::Data were obtained on soluble oestrogen (ER) and progesterone (PR) receptors from 273 primary breast tumours, using an enzyme immunoassay (EIA) and ligand binding assay with dextran-coated charcoal (DCC) or isoelectric focussing separations. The p29 and total cathepsin D content was also assayed in the same samples. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90246-r
更新日期:1992-10-21 00:00:00
abstract::The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90057-1
更新日期:1986-03-01 00:00:00
abstract::Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90050-5
更新日期:1989-11-30 00:00:00
abstract::Gastric cancer (GC) is a major threat to human health, and its prognosis is poor due to the lack of appropriate biomarkers. LncRNAs are a group of non-protein-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. LncRNAs play essential roles in GC initiation and development in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.11.011
更新日期:2016-02-01 00:00:00
abstract::To clarify the detailed molecular mechanism underlying cellular responses to nonthermal low-intensity pulsed ultrasound (LIPUS), gene expression patterns and genetic networks in human lymphoma U937 cells were examined using global-scale microarrays and computational gene expression analysis tools. Six hours after LIPU...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.05.018
更新日期:2008-11-08 00:00:00
abstract::There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+) stem cells in colon tumorigenesis has been established; however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (HF) feeding on col...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.10.001
更新日期:2015-12-28 00:00:00
abstract::Vemurafenib, a BRAF inhibitor, elicits in ∼80% of BRAFV600E-mutant melanoma patients a transient anti-tumor response which precedes the emergence of resistance. We tested whether an acidic tumor microenvironment may favor a BRAF inhibitor resistance. A375M6 BRAFV600E melanoma cells, either exposed for a short period o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.08.010
更新日期:2017-11-01 00:00:00
abstract::Breast fluid which bathes the mammary ductal epithelium may contain tumorogenic components. In view of the number of tobacco components inhaled during smoking, it was of interest whether nicotine and its metabolites were present in this fluid. Fluid was obtained from the nipple from menstruating women who were smokers...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80042-7
更新日期:1979-04-01 00:00:00
abstract::EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.01.003
更新日期:2017-04-01 00:00:00
abstract::The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.01.024
更新日期:2016-06-01 00:00:00
abstract::Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.11.016
更新日期:2009-09-08 00:00:00
abstract::Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique. We review the onc...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/0304-3835(94)03671-5
更新日期:1995-03-23 00:00:00
abstract::The mesenchymal (MES) subtype of glioblastoma (GBM) indicated a more malignant phenotype and worse prognosis compared with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided an approach for clinical intervention. However, few miRNAs have been identified to participate...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.03.002
更新日期:2017-06-28 00:00:00
abstract::Polyphenolic antioxidants protected against Al-phthalocyanine tetrasulfonate-sensitized photohemolysis of human erythrocytes. A quantitative structure-activity relationship has been obtained to describe the protective effects of di- and trihydroxybenzenes: log cI(50) (microM)=(1.8620+/-1.5565)+(3.6366+/-2.8245) E(1)(7...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00469-9
更新日期:2000-08-31 00:00:00
abstract::The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03688-s
更新日期:1995-03-02 00:00:00