Biology of mouse mammary tumor virus (MMTV).

abstract：:Cancer cells are shed into the blood stream and are exposed to hemodynamic shear stress during metastasis. It has been shown that shear stress can destroy circulating tumor cells (CTCs) both in vitro and in vivo. However, it remains unclear whether shear stress can modulate the properties and functions of tumor cells ...

journal_title：Cancer letters

authors： Ma S,Fu A,Chiew GG,Luo KQ

更新日期：2017-03-01 00:00:00

abstract：:We investigated a role for Hedgehog signalling in colon cancer by studying transcription of members of the pathway in human colorectal carcinoma cell lines. We determined the methylation status and screened the gene encoding the Hedgehog receptor-associated protein Smoothened (SMO) for putative mutations. In three cel...

journal_title：Cancer letters

authors： Zhu Y,James RM,Peter A,Lomas C,Cheung F,Harrison DJ,Bader SA

更新日期：2004-04-30 00:00:00

abstract：:Osteosarcoma is the most common osteogenic malignant tumor characterized by a high level of malignancy, relapse, metastasis and poor prognosis. S100A4 has been implicated in the proliferation, cell cycle progression, and metastasis of many malignant tumors, although the roles of S100A4 in osteosarcoma have not been do...

journal_title：Cancer letters

authors： Ma X,Yang Y,Wang Y,An G,Lv G

更新日期：2010-12-28 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00

abstract：:The effect of the naturally occurring flavonol, quercetin, was investigated on cell growth and metabolism of two human carcinoma cell lines, HT29 and Caco-2 cells, both during the exponentially growing phase and after confluence. Our results show clearly that, after a 48-h period of treatment, quercetin (in the range ...

journal_title：Cancer letters

authors： Agullo G,Gamet L,Besson C,Demigné C,Rémésy C

更新日期：1994-11-25 00:00:00

abstract：:The effects of trisodium nitrilotriacetate monohydrate (Na3 NTA.H2O) nitrilotriacetic acid (H3NTA) and ammonium chloride (NH4Cl) on two-stage urinary bladder carcinogenesis were examined. Carcinogenesis was initiated by administration of 0.2% N-bis (2-hydroxypropyl)-nitrosamine (DHPN) to male Wistar rats in the drinki...

journal_title：Cancer letters

authors： Kitahori Y,Shimoyama T,Ohshima M,Matsuki H,Hashimoto H,Minami S,Konishi N,Hiasa Y

更新日期：1988-12-01 00:00:00

abstract：AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB...

journal_title：Cancer letters

authors： Sedlak J,Reinerova M,Hunakova L,Ausch C,Chorvath B,Rosen H,Moroz C

更新日期：1995-07-20 00:00:00

abstract：:The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

journal_title：Cancer letters

authors： Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

更新日期：1998-11-27 00:00:00

abstract：:Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...

journal_title：Cancer letters

authors： Misra RR,Ratnasinghe D,Tangrea JA,Virtamo J,Andersen MR,Barrett M,Taylor PR,Albanes D

更新日期：2003-03-10 00:00:00

abstract：:Evidence is growing that low folate status may be a factor in the aetiology of several cancers, including breast cancer. The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic. We report a case-control study of two functional polymorphisms in MTHFR, dietary fola...

journal_title：Cancer letters

authors： Sharp L,Little J,Schofield AC,Pavlidou E,Cotton SC,Miedzybrodzka Z,Baird JO,Haites NE,Heys SD,Grubb DA

更新日期：2002-07-08 00:00:00

abstract：:Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...

journal_title：Cancer letters

authors： Jennerwein M,Andrews PA

更新日期：1994-06-30 00:00:00

abstract：:A novel second generation retroviral producer cell strategy (an adenoviral/retroviral combined delivery system) has been developed by this laboratory. In the present studies, this delivery system was used to examine its delivery efficiency in vitro and in vivo by using a marker gene, LacZ, and a therapeutic gene, herp...

journal_title：Cancer letters

authors： Pan Y,Zhai P,Dashti AM,Wu S,Lin X,Wu M

更新日期：2002-10-28 00:00:00

abstract：:Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

journal_title：Cancer letters

authors： Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

更新日期：2013-05-01 00:00:00

abstract：:Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor...

journal_title：Cancer letters

authors： Van de Velde M,Ebroin M,Durré T,Joiret M,Gillot L,Blacher S,Geris L,Kridelka F,Noel A

更新日期：2021-01-28 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD10...

journal_title：Cancer letters

authors： Zhang C,Qiao H,Guo W,Liu Y,Yang L,Liu Y,Jin B,Fu M,Wang G,Li W

更新日期：2019-07-28 00:00:00

abstract：:We assessed whether current therapies could lead to hematogenous dissemination of malignant hepatocytes in hepatocellular carcinoma (HCC) patients using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) for alpha-fetoprotein (afp) and albumin (alb) mRNAs. We analyzed 137 peripheral blood sampl...

journal_title：Cancer letters

authors： Wong IH,Yeo W,Leung T,Lau WY,Johnson PJ

更新日期：2001-06-26 00:00:00

abstract：:Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...

journal_title：Cancer letters

authors： Hu X,Liu Y,Qin C,Pan Z,Luo J,Yu A,Cheng Z

更新日期：2014-04-28 00:00:00

abstract：:Tumour cell attachment to the endothelial cell lining of the circulatory system is of utmost importance in the process of cancer spread. We describe here a method of quantifying tumour cell attachment to an endothelial cell layer in vitro, using the fluorescent carbocyanine dye, 1,1'-dioctadecyl-3,3,3',3'-tetramethyli...

journal_title：Cancer letters

authors： Hiscox S,Jiang WG

更新日期：1997-01-30 00:00:00

abstract：:We repeated and extended a 1973 study by Sander and Schweinsberg on forestomach tumorigenesis in mice by methylbenzylnitrosamine (MBZN). Groups of 80 adult CD-1 mice of both sexes received 96 mg/kg of MBZN subdivided into 24 doses of 4 mg/kg, 12 doses of 8 mg/kg or 6 doses of 16 mg/kg (groups 1-3, respectively). The m...

journal_title：Cancer letters

authors： Schneider P,Hinrichs S,Zulim R,Towery R,Morris C,Mirvish SS

更新日期：1996-04-19 00:00:00

abstract：:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...

journal_title：Cancer letters

authors： Augoff K,Hryniewicz-Jankowska A,Tabola R

更新日期：2015-03-01 00:00:00

abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

journal_title：Cancer letters

authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

更新日期：2016-05-01 00:00:00

abstract：:D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was...

journal_title：Cancer letters

authors： Yang YN,Chou KM,Pan WY,Chen YW,Tsou TC,Yeh SC,Cheung CH,Chen LT,Chang JY

更新日期：2011-10-01 00:00:00

abstract：:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...

journal_title：Cancer letters

authors： Mori Y,Niwa T,Takahashi H,Toyoshi K,Denda A,Takahashi S,Konishi Y

更新日期：1983-04-01 00:00:00

abstract：:The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

journal_title：Cancer letters

authors： Yan X,Chua MS,Sun H,So S

更新日期：2008-04-08 00:00:00

abstract：:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In this paper, we report the comprehensive LOH analyses with microsatellite markers and their results at chromosome 8p11.1-q13.3 in gastric cancer. The microsatellite markers D8S2323 and D8S2330 exhibited high LOH frequencies, 54.2 and 57.1%, respect...

journal_title：Cancer letters

authors： Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

更新日期：2004-09-15 00:00:00

abstract：:The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....

journal_title：Cancer letters

authors： Han Y,Li H,Guan Y,Huang J

更新日期：2016-09-01 00:00:00

abstract：:Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biologi...

journal_title：Cancer letters

authors： Kumar A,Deep G

更新日期：2020-09-28 00:00:00

abstract：:In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, con...

journal_title：Cancer letters

authors： Yoon MJ,Kim EH,Kwon TK,Park SA,Choi KS

更新日期：2012-11-28 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a macrophage-derived multifunctional cytokine that acts as a cytostatic or cytotoxic agent in many tumor cells. However, the molecular mechanisms by which tumor cells become sensitive to the cytotoxic action of TNF-alpha are not clear. In this study we demonstrated that the c...

journal_title：Cancer letters

authors： Park IC,Park MJ,Lee SH,Choe TB,Jang JJ,Hong SI

更新日期：1998-03-13 00:00:00

abstract：:The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer...

journal_title：Cancer letters

authors： Minagawa A,Takaku H,Takagi M,Nashimoto M

更新日期：2005-05-26 00:00:00