Abstract:
AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB-468 was determined with the aid of flow cytometry and monoclonal antibodies. RESULTS:PLF induced a transient up-regulation followed by a down regulation of cell surface protectin (CD59 antigen) on the cell surface of T47D and to a lesser extent, BT-20 human breast carcinoma cell lines. Furthermore, PLF down-regulated cell surface expression of CEA-related CD66 antigen on both these cell lines. No PLF-induced alterations of protectin, CD66 antigen and HLA class I antigen were found on the MDA-MB-468 breast cancer cell line. CONCLUSIONS:breast cancer-associated p43 induces alterations of the expression of cell surface molecules in breast cancer cells which could have an effect on the modulation of cancer cell adhesive interactions.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sedlak J,Reinerova M,Hunakova L,Ausch C,Chorvath B,Rosen H,Moroz Cdoi
10.1016/0304-3835(95)03831-gsubject
Has Abstractpub_date
1995-07-20 00:00:00pages
101-6issue
1eissn
0304-3835issn
1872-7980pii
030438359503831Gjournal_volume
94pub_type
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