Abstract:
:Prostate-specific membrane antigen (PSMA), an established enzyme-biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSMA-targeted PDT resulted in rapid disruption of microtubules (alpha-/beta-tubulin), microfilaments (actin), and intermediate filaments (cytokeratin 8/18) in the cytoplasm of LNCaP cells. The collapse of cytoplasmic microtubules and the later nuclear translocation of alpha-/beta-tubulin were the most dramatic alternation. It is likely that these early changes of cytoskeletal networks are partly involved in the initiation of cell death.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Liu T,Wu LY,Berkman CEdoi
10.1016/j.canlet.2010.04.003subject
Has Abstractpub_date
2010-10-01 00:00:00pages
106-12issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00207-7journal_volume
296pub_type
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