当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells.

Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells.

Abstract：

:In the present study, Tbx3, a member of the T-box family of transcription factors, was identified as an up-regulated gene by mRNA differential display in the regression (apoptosis) stage after uracil-induction of papillomatosis in the rat urinary bladder. Immunohistochemical analysis revealed that apoptosis cells are negative and apoptosis resistant cells are positive for Tbx3 expression. That suggests that Tbx3 is an apoptosis resistant gene rather than an apoptosis induced gene. We have found the rat bladder carcinoma cell line, BC31, to feature Tbx3 expression detectable by RT-PCR. To investigate its role in such cancer cells, they were transfected with an anti-sense Tbx3 expression vector. The obtained stable transfectant clones showed reduced expression of Tbx3 and much slower cell growth, as compared with mock transfectants, and many apoptotic cells were observed under normal culture conditions. These results indicate that Tbx3 is a negative regulator of apoptosis in bladder normal epithelial cells and suppression of Tbx3 expression causes inhibition of cell proliferation and induction of apoptosis in BC31, a rat bladder carcinoma cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Ito A,Asamoto M,Hokaiwado N,Takahashi S,Shirai T

doi

10.1016/j.canlet.2004.07.051

keywords:

subject

Has Abstract

pub_date

2005-02-28 00:00:00

pages

105-12

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(04)00647-0

journal_volume

219

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P).

    abstract：:In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00222-x

    authors： Kobayashi K,Mutai M,Goto K,Inada K,Tsukamoto T,Nakanishi H,Tatematsu M

    更新日期：1997-09-16 00:00:00

  • DNA-adduct formation in the forestomach of rats treated with 3-tert-butyl-4-hydroxyanisole and its metabolites as assessed by an enzymatic 32P-postlabeling method.

    abstract：:Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(89)90117-1

    authors： Saito K,Nakagawa S,Yoshitake A,Miyamoto J,Hirose M,Ito N

    更新日期：1989-12-01 00:00:00

  • Circulating tumor cell mRNAs in peripheral blood from hepatocellular carcinoma patients under radiotherapy, surgical resection or chemotherapy: a quantitative evaluation.

    abstract：:We assessed whether current therapies could lead to hematogenous dissemination of malignant hepatocytes in hepatocellular carcinoma (HCC) patients using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) for alpha-fetoprotein (afp) and albumin (alb) mRNAs. We analyzed 137 peripheral blood sampl...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00455-4

    authors： Wong IH,Yeo W,Leung T,Lau WY,Johnson PJ

    更新日期：2001-06-26 00:00:00

  • Frequent ras gene mutations in squamous cell cervical cancer.

    abstract：:Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03857-s

    authors： Wong YF,Chung TK,Cheung TH,Lam SK,Xu YG,Chang AM

    更新日期：1995-08-16 00:00:00

  • IL-6 induced M1 type macrophage polarization increases radiosensitivity in HPV positive head and neck cancer.

    abstract：:Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.04.032

    authors： Chen X,Fu E,Lou H,Mao X,Yan B,Tong F,Sun J,Wei L

    更新日期：2019-08-01 00:00:00

  • MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma.

    abstract：:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.01.003

    authors： Zhang L,Sun ZJ,Bian Y,Kulkarni AB

    更新日期：2013-05-01 00:00:00

  • Topical inhibition of oral carcinoma cell with polymer delivered celecoxib.

    abstract：:Celecoxib has a potential role for oral cancer chemoprevention but its systemic side effects are a concern. Topical chemoprevention is a promising way to reduce the toxicity. This study was designed to determine whether topical application of polymer delivered celecoxib would have an inhibitory effect on human oral ca...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(03)00272-6

    authors： Wang Z,Polavaram R,Shapshay SM

    更新日期：2003-07-30 00:00:00

  • The binding of polycyclic aromatic hydrocarbon diol-epoxides to DNA.

    abstract：:Diol-epoxide derivatives of polycyclic aromatic hydrocarbons are the ultimate carcinogenic forms of these compounds encountered in vivo. Using a novel electro-fluorescence apparatus, we report that, like the (+/-)-anti-diol-epoxide of benzo[a]pyrene (BP), the similar diol-epoxides of benzo[a]anthracene (BA) and 3-meth...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90049-1

    authors： Ridler P,Jennings B

    更新日期：1984-02-01 00:00:00

  • Ultrasound-induced apoptosis in the presence of Sonazoid and associated alterations in gene expression levels: a possible therapeutic application.

    abstract：:Ultrasound (US) has been shown to induce apoptosis and cell lysis in cancer cells. In this study, we report on the potential of using Sonazoid, a new echo-contrast agent, that is chemically more stable and US-resistant in combination with US in cancer therapy. The biological effects and their mechanisms in the presenc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.06.029

    authors： Furusawa Y,Zhao QL,Hassan MA,Tabuchi Y,Takasaki I,Wada S,Kondo T

    更新日期：2010-02-01 00:00:00

  • Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells.

    abstract：:Treatment resistance in acute lymphoblastic leukemia (ALL) is often caused by defects in programmed cell death, e.g. by overexpression of Inhibitor of Apoptosis (IAP) proteins. Here, we report that small-molecule Smac mimetics (i.e. BV6, LCL161, birinapant) that neutralize x-linked IAP (XIAP), cellular IAP (cIAP)1 and...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.02.040

    authors： Gerges S,Rohde K,Fulda S

    更新日期：2016-05-28 00:00:00

  • Dietary regulation of mammary tumorigenesis in RIII/Sa mice: investigation of a possible mechanism.

    abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90261-5

    authors： Li HW,Zhao W,Sarkar NH

    更新日期：1994-05-16 00:00:00

  • Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil.

    abstract：:Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.10.016

    authors： Takasuka N,Takahashi M,Hori Y,Kitahashi T,Iigo M,Imai T,Yoshimi N,Sugimura T,Wakabayashi K

    更新日期：2009-03-08 00:00:00

  • Optimized dissociation protocol for isolating human glioma stem cells from tumorspheres via fluorescence-activated cell sorting.

    abstract：:Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.04.022

    authors： Lv D,Ma QH,Duan JJ,Wu HB,Zhao XL,Yu SC,Bian XW

    更新日期：2016-07-10 00:00:00

  • Melanoma-associated antigen genes - an update.

    abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2010.10.021

    authors： Sang M,Wang L,Ding C,Zhou X,Wang B,Wang L,Lian Y,Shan B

    更新日期：2011-03-28 00:00:00

  • Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma.

    abstract：:Tumor acidity is now considered an important determinant of drug-resistance and tumor progression, and anti-acidic approaches, such as Proton Pump inhibitors (PPIs), have demonstrated promising antitumor and chemo-sensitizing efficacy. The main purpose of the present study was to evaluate the possible PPI-induced sens...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.10.017

    authors： Azzarito T,Venturi G,Cesolini A,Fais S

    更新日期：2015-01-28 00:00:00

  • Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.

    abstract：:Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of trans...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.01.016

    authors： Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A

    更新日期：2014-05-01 00:00:00

  • Potent tumorigenicity of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene in the neonatal B6C3F (1) male mouse.

    abstract：:The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96%...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04111-0

    authors： Fu PP,Von Tungeln LS,Zhan DJ,Bucci T

    更新日期：1996-03-19 00:00:00

  • Promoting effect of intestinal Pseudomonas aeruginosa on gastric tumorigenesis in rats with N-methyl-N'-nitro-N-nitrosoguanidine.

    abstract：:The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90174-x

    authors： Morishita Y,Shimizu T

    更新日期：1983-01-01 00:00:00

  • Immune modulation in advanced radiotherapies: Targeting out-of-field effects.

    abstract：:By virtue of being a localized treatment modality, radiotherapy is unable to deliver a tumoricidal radiation dose to tissues outside of the irradiated field. Nevertheless, ionizing radiation may result in radiation damage mediated by a bystander like effect away from the irradiated field, but this response is likely t...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.04.007

    authors： Hanna GG,Coyle VM,Prise KM

    更新日期：2015-11-28 00:00:00

  • Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.

    abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.10.018

    authors： Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

    更新日期：2008-02-18 00:00:00

  • Potential of endogenous formation of volatile nitrosamines from Nigerian vegetables and spices.

    abstract：:Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(91)90160-j

    authors： Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

    更新日期：1991-05-24 00:00:00

  • Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells.

    abstract：:Substantial evidence from epidemiological studies supports the inverse association between the intake of fruits, vegetables and other plant products and cancer incidence. Cancer-preventive constituents of fruits and vegetables may inhibit carcinogen activation, enhance carcinogen detoxification, prevent carcinogens fr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00723-6

    authors： Tatman D,Mo H

    更新日期：2002-01-25 00:00:00

  • Tea and health: a historical perspective.

    abstract：:In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...

    journal_title：Cancer letters

    pub_type： 历史文章,杂志文章

    doi：10.1016/s0304-3835(97)04691-0

    authors： Weisburger JH

    更新日期：1997-03-19 00:00:00

  • Binding of adult T-cell leukemia virus to various hematopoietic cells.

    abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90004-1

    authors： Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

    更新日期：1984-01-01 00:00:00

  • AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo.

    abstract：:Activation of the BTLA-HVEM co-inhibitory signaling pathway impairs antitumor immunity. Our previous study demonstrated that the extracellular domain of murine BTLA (the soluble form of BTLA) can facilitate HSP70 vaccine-triggered antitumor immunity by blocking BTLA-HVEM interactions in a murine TC-1 non-metastatic tu...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.08.006

    authors： Han L,Wang W,Lu J,Kong F,Ma G,Zhu Y,Zhao D,Zhu J,Shuai W,Zhou Q,Chen P,Ye L,Tao J,Ahmad S,Li F,Sun J

    更新日期：2014-11-28 00:00:00

  • In vivo formation of DNA-adducts in mouse skin DNA by tamoxifen.

    abstract：:Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of T...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03802-4

    authors： Cai Q,Wei H

    更新日期：1995-06-08 00:00:00

  • Application of CRISPR-mediated genome engineering in cancer research.

    abstract：:Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research communi...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2016.03.029

    authors： Sayin VI,Papagiannakopoulos T

    更新日期：2017-02-28 00:00:00

  • Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor.

    abstract：:To discover novel drugs for neuroblastoma treatment, we have previously screened a panel of drugs and identified 30 active agents against neuroblastoma cells. Here we performed microarray gene expression analysis to monitor the impact of these agents on a neuroblastoma cell line and used the connectivity map (cMAP) to...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.01.004

    authors： Gheeya J,Johansson P,Chen QR,Dexheimer T,Metaferia B,Song YK,Wei JS,He J,Pommier Y,Khan J

    更新日期：2010-07-01 00:00:00

  • Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.

    abstract：:Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90023-1

    authors： Schallreuter KU,Wood JM

    更新日期：1987-09-01 00:00:00

  • In vitro upregulation of carcinoembryonic antigen expression by combinations of cytokines.

    abstract：:Interferons are able to enhance the expression of carcinoembryonic antigen (CEA) on tumour cells, allowing improved tumour targeting. In this report the hypothesis is tested that combinations of cytokines may further increase the tumour antigen expression. The combination of both IFN-gamma and IFN-alpha with interleuk...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00007-5

    authors： Verhaar MJ,Damen CA,Zonnenberg BA,Blijham GH

    更新日期：1999-05-03 00:00:00