Abstract:
:Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of TAM for 6 h, total DNA adduct levels in skin were increased by 2.5- (1 mumol TAM), 4.5- (5 mumol TAM) and 4.8-fold (10 mumol TAM), respectively. In addition, at least four novel DNA adducts were observed. Time-course studies showed that TAM-induced DNA adducts reach a peak at 6 h post-treatment. However, the pattern of TAM-induced DNA adducts was different from that induced by DMBA (a potent skin carcinogen). TAM has been found to form DNA-adducts in the liver and kidney of rodents. Our work confirms the genotoxic effects observed by other investigators by showing that TAM also causes DNA-adducts formation in mouse skin. Since TAM is widely used for the treatment of breast cancer and currently for chemo-prevention trials, further studies should be conducted to assess the potential risk of long-term use of TAM in humans.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Cai Q,Wei Hdoi
10.1016/0304-3835(95)03802-4subject
Has Abstractpub_date
1995-06-08 00:00:00pages
187-92issue
2eissn
0304-3835issn
1872-7980pii
0304383595038024journal_volume
92pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.09.022
更新日期:2009-02-18 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90134-h
更新日期:1992-12-24 00:00:00
abstract::Nuclear factor-kappa B (NF-kappaB) activation by tumor necrosis factor-alpha (TNF-alpha) attenuates the TNF-alpha-induced apoptosis pathway. Thus, blockage of NF-kappaB activity may improve the anti-cancer activity of TNF-alpha. HA14-1 induces apoptosis in various human cancer cells, and the molecular mechanisms of th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.11.014
更新日期:2010-06-01 00:00:00
abstract::Some proteins of the extracellular matrix known as matricellular proteins have regulatory function in all aspects of physiological and pathological stroma rearrangement. Many aspects of their activity are related to inflammation and immune response suggesting their role in bridging inflammation and cancer. ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.03.027
更新日期:2008-08-28 00:00:00
abstract::Prostate cancer urgently needs an efficient therapy. Here we demonstrated that cisplatin combined with gene therapy by transfecting the attenuated Salmonella that carry a plasmid containing p53 gene and MDM2 siRNA provided a super-synergistic effect on the inhibition of prostate cancer growth in vivo. This synergistic...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.05.028
更新日期:2013-08-28 00:00:00
abstract::The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90214-i
更新日期:1990-09-01 00:00:00
abstract::Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00407-x
更新日期:2002-12-10 00:00:00
abstract::Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90023-5
更新日期:1979-11-01 00:00:00
abstract::The past two decades have seen a dramatic change in cancer treatment paradigms. Anticancer agents are no longer being developed based on empiricism and serendipity, but are now being aimed to inhibit a validated target that is relatively specific for tumours rather than normal cells. The vast majority of cancers arise...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.03.012
更新日期:2007-01-08 00:00:00
abstract::The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00418-8
更新日期:2000-04-03 00:00:00
abstract::Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90181-8
更新日期:1985-07-01 00:00:00
abstract::Prostate-specific membrane antigen (PSMA), an established enzyme-biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSM...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.04.003
更新日期:2010-10-01 00:00:00
abstract::Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.07.042
更新日期:2014-12-28 00:00:00
abstract::Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SM...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.02.028
更新日期:2020-05-01 00:00:00
abstract::The bmi-1 gene was identified as a common proviral integration site in Moloney murine leukemia virus. In the present studies, we cloned and sequenced the rat bmi-1 gene by reverse transcriptase-polymerase chain reaction (RT-PCR) using degenerate PCR primers of homologous sequences between mouse and human. We found 93%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00192-x
更新日期:1998-11-13 00:00:00
abstract::While the vast majority of cancers are believed to occur sporadically, most forms of cancer, both adult and paediatric, have a hereditary equivalent. In the case of adult malignancies, these include hereditary breast and ovarian cancer and syndromes such as the multiple endocrine neoplasias types 1 and 2 characterised...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(02)00023-x
更新日期:2002-07-26 00:00:00
abstract::We measured colonic effluent samples from 10 patients with colorectal cancer, 13 with adenomatous polyps, 14 with normal colons and compared them to 10 patients with inflammatory bowel disease by measuring this CA19-9 content. Results showed considerable overlap between the different pathologic categories, making diff...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90043-h
更新日期:1991-10-01 00:00:00
abstract::To obtain an optimal condition for ultrasound (US)-induced apoptosis that could be useful for cancer therapy, we applied low intensity pulsed US to sonicate U937 cells in vitro. Cells were then incubated at different time intervals before measuring apoptosis. The apoptosis was assessed by DNA fragmentation and phospha...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.08.034
更新日期:2005-04-28 00:00:00
abstract::The antitumor activity of cytokine-induced killer (CIK) cells can be increased by co-culturing them with tumor lysate-pulsed dendritic cells (tDCs); this phenomenon has been studied mainly at the population level. Using time-lapse imaging, we examined how CIK cells gather information from tDCs at the single-cell level...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.05.020
更新日期:2016-08-10 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the changes in the number of HSF1 granules in the nucleus caused by different degree of heat stress. MATERIALS AND METHODS:A human esophageal cancer cell line, TE-2, was used. HSF1 granules were examined in an immunofluorescence study, and the changes in the average numb...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00481-6
更新日期:2003-12-08 00:00:00
abstract::Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.01.007
更新日期:2014-05-01 00:00:00
abstract::Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.04.005
更新日期:2017-07-28 00:00:00
abstract::We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04444-8
更新日期:1996-12-03 00:00:00
abstract::We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover, we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:
更新日期:1995-11-27 00:00:00
abstract::Accumulating evidence suggested that the irreversible tyrosine kinase inhibitors (TKIs) have potential to override the acquired resistance to target-based therapies. Herein, we reported IC-4 as a novel irreversible TKI for epidermal growth factor receptor (EGFR). IC-4 potentially suppressed proliferation, induced apop...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.07.005
更新日期:2013-10-28 00:00:00
abstract::Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(02)00621-3
更新日期:2003-02-28 00:00:00
abstract::The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90133-7
更新日期:1983-05-01 00:00:00
abstract::Urethane-induced lung tumors and their genetic changes were investigated in transgenic (Tg) mice carrying a human prototype c-Ha-ras gene (rasH2 mice). Male and female rasH2 mice and non-transgenic (non-Tg) littermates were injected intraperitoneally with 1000 mg/kg of urethane once or three times at 2-day intervals. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00372-4
更新日期:2000-05-29 00:00:00
abstract::Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.12.014
更新日期:2017-03-01 00:00:00
abstract::Radiotherapy (RT) is one of the most important strategies in cancer treatment. Radioresistance is a major challenge to RT and results in locoregional recurrence and metastasis. Thus, there is a great interest in investigating biomarkers to distinguish radiosensitive from radioresistant (RR) cancer patients. The develo...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.09.013
更新日期:2015-12-28 00:00:00