Abstract:
:The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids examined inhibited AH109A invasion in a dose-dependent manner up to 5 microM. Cancer cells previously cultured with hypoxanthine (HX) and xanthine oxidase (XO) showed a highly invasive activity. Carotenoids, 5 microM of beta-carotene and astaxanthin, suppressed this reactive oxygen species-potentiated invasive capacity by simultaneously treating AH109A cells with the carotenoids, HX and XO. These results suggest that the antioxidative property of these carotenoids may be involved in their anti-invasive action.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kozuki Y,Miura Y,Yagasaki Kdoi
10.1016/s0304-3835(99)00418-8keywords:
subject
Has Abstractpub_date
2000-04-03 00:00:00pages
111-5issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(99)00418-8journal_volume
151pub_type
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