Abstract：
:The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary thyroid carcinoma (PTC) tissue. Additionally, the expression of dCK was estimated, in medullary thyroid carcinoma (MTC). For control, the RNA expression levels for all the enzymes were measured in macroscopically unchanged thyroid tissue. Reverse transcriptase-polymerase chain reaction (RT-PCR) and densitometry were employed for mRNA expression measurements, with the beta-actin gene as a control housekeeping gene. The levels of mRNA expression for TK1, dCK and dThdPase in human PTC, as well as mRNA expression for dCK in MTC, were significantly higher than mRNA expressions for those enzymes found in macroscopically unchanged thyroid tissue. It is concluded that an increased expression of mRNA, specific for TK1, dCK and dThdPase, may be involved in carcinogenic processes in the human thyroid.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Karbownik M,Brzezianska E,Lewinski Adoi
10.1016/j.canlet.2004.10.044keywords:
subject
Has Abstractpub_date
2005-07-28 00:00:00pages
267-73issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(04)00857-2journal_volume
225pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.06.001
更新日期：2010-01-01 00:00:00
abstract：:RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.05.028
更新日期：2011-10-28 00:00:00
abstract：:The Syrian hamster embryo cell transformation assay has been used to investigate the effect of two synthetic antioxidants on morphological transformation induced by the initiator benzo[a]pyrene (BP). A two-stage protocol was employed with an initiation phase of 2 days and a subsequent promotion phase of 5 days. When 1...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90024-8
更新日期：1986-11-01 00:00:00
abstract：:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.10.005
更新日期：2021-01-01 00:00:00
abstract：:During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the fo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(81)90052-5
更新日期：1981-03-01 00:00:00
abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.09.016
更新日期：2014-12-01 00:00:00
abstract：:Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.02.002
更新日期：2014-05-28 00:00:00
abstract：:Virtually all cervical cancer morbidities are associated with genital skin or mucosa cell infection with human papillomavirus (HPV). The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation. Employing quantitative real-time PCR and Western blot analysis...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.06.030
更新日期：2008-12-08 00:00:00
abstract：:The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00037-8
更新日期：1998-05-15 00:00:00
abstract：:The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00477-1
更新日期：1998-02-27 00:00:00
abstract：:Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.04.005
更新日期：2017-07-28 00:00:00
abstract：:Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90098-4
更新日期：1986-10-01 00:00:00
abstract：:Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.09.016
更新日期：2008-01-18 00:00:00
abstract：:Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.10.027
更新日期：2005-06-01 00:00:00
abstract：:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90007-8
更新日期：1986-05-01 00:00:00
abstract：:Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating aspects of this immunosuppressive milieu is a goal of combination treatment approaches. Radia...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.12.045
更新日期：2021-01-12 00:00:00
abstract：:Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were fo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90027-7
更新日期：1993-04-15 00:00:00
abstract：:Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovir...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.03.009
更新日期：2017-06-28 00:00:00
abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90175-8
更新日期：1986-09-01 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated wit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.01.009
更新日期：2011-03-28 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.06.013
更新日期：2018-09-28 00:00:00
abstract：:Large marker chromosomes were found in 2 hormone-independent (HI) GR mouse mammary tumors, i.e. a tumor (TSl 75) that was already HI at the first transplantation, and a tumor (TSl 66) that became HI at the 19th passage. These marker chromosomes appear to be translocations to distal and proximal ends of chromosome 1, r...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90109-0
更新日期：1985-06-01 00:00:00
abstract：:The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.007
更新日期：2020-11-01 00:00:00
abstract：:Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90112-6
更新日期：1986-08-01 00:00:00
abstract：:AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.023
更新日期：2011-05-01 00:00:00
abstract：:Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.03.018
更新日期：2013-08-19 00:00:00
abstract：:Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.01.012
更新日期：2009-06-18 00:00:00
abstract：:NF-kappaB is activated in many types of cancer. Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8). Thus, inhibition of serine 276 phosphorylation may prevent metastasis and angiogen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.10.015
更新日期：2010-05-28 00:00:00
abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.08.024
更新日期：2013-07-01 00:00:00
abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor in Chief. The term miR-143 has been used instead of the term miR-143* in the introduction and discussion which is misleading...
journal_title：Cancer letters
pub_type： 杂志文章,收录出版
doi：10.1016/j.canlet.2016.01.023
更新日期：2016-04-01 00:00:00
