Abstract:
:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted therapy may be effective for the treatment of oesophageal cancer. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase with kinase activity and scaffolding function, could be overexpressed in a variety of solid tumours, including oesophageal cancer. FAK participates in survival, proliferation, progression, adhesion, invasion, migration, epithelial-to-mesenchymal transition, angiogenesis, DNA damage repair, and other biological processes through multiple signalling pathways in cancer cells. It plays an important role in the occurrence and development of tumours and has been linked to the prognosis of oesophageal cancer. FAK has been suggested as a potential therapeutic target in oesophageal cancer; thus, the combination of FAK inhibitors with chemotherapy, radiotherapy, and immunotherapy is expected to prolong the survival of patients. This paper presents a brief overview of the structure of FAK and its potential role in oesophageal cancer, providing a rationale for the future application of FAK inhibitors in the treatment of the disease.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zhang Y,Liu S,Zhou S,Yu D,Gu J,Qin Q,Cheng Y,Sun Xdoi
10.1016/j.canlet.2020.10.005subject
Has Abstractpub_date
2021-01-01 00:00:00pages
93-103eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30502-4journal_volume
496pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.10.013
更新日期:2010-05-28 00:00:00
abstract::The effect of consumption of Brussels sprouts on the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) into human urine was investigated. Ten non-smoking volunteers (five males and five females) were randomly assigned to two groups. Five volunteers started on a diet of 300 g of glucosinolate-free vegetables w...
journal_title:Cancer letters
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3835(97)04641-7
更新日期:1997-03-19 00:00:00
abstract::Methylnitrosourea (MNU)-induced carcinomas in organ-cultured human pancreas when injected into nude mice produced subcutaneous carcinomas none of which recognizable as being of acinar cell origin. Both monoclonal antibody to acinar cell surface marker produced by hybridoma, and in vitro tumor cell differentiation were...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90040-4
更新日期:1982-02-01 00:00:00
abstract::Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00131-7
更新日期:1999-09-01 00:00:00
abstract::Discovery of activating mutations in epidermal growth factor receptor (EGFR) as a predictive biomarker for first-generation EGFR tyrosine kinase inhibitors (TKIs) has initiated an era of precision oncology for the treatment of advanced EGFR-mutant non-small cell lung cancer (NSCLC). Despite the robust efficacy of firs...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.05.044
更新日期:2019-09-10 00:00:00
abstract::The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03922-j
更新日期:1995-09-04 00:00:00
abstract::Interferon-beta (IFN-β) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-β, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN-β-induced increase in endogenous PML contri...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.04.013
更新日期:2012-10-28 00:00:00
abstract::Imatinib has revolutionized treatment strategies for chronic myeloid leukemia patients: long-term overall survival was reported to be up to 80% at 8 years of follow-up in respondent patients. Despite the straightforward results obtained, it has been estimated a failure rate per year of 2-4%. Several attempts to improv...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.03.021
更新日期:2012-09-28 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer with poor prognosis. Despite extensive efforts, the current treatment methods have limited success. Therefore, novel therapeutic approaches are required. The pancreatic tumor microenvironment is rich in growth factors and inflammato...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.07.014
更新日期:2014-04-10 00:00:00
abstract::Stem cell factor (SCF) is a multifunctional cytokine responsible for tumorigenesis and progression. In this study, we report that increased expression of SCF in hepatocellular carcinoma (HCC) patients is highly associated with metastasis and poor prognosis. SCF inhibition with RNAi inhibited HCC cell migration, invasi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.01.032
更新日期:2017-05-01 00:00:00
abstract::Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma. Intratumoral hypoxia, i.e. reduced oxygen supply following uncontrolled proliferation of cancer...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.02.030
更新日期:2019-05-28 00:00:00
abstract::Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.03.040
更新日期:2018-07-01 00:00:00
abstract::NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme which is associated with poor prognosis in human breast, colon, lung and liver cancers. However, the molecular mechanisms underlying the pro-tumorigenic function of NQO1 remains unclear. This study investigated the function of NQO1 in the context of hep...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.02.053
更新日期:2019-06-01 00:00:00
abstract::Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines. Gel shift assay showed that induced c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.003
更新日期:2004-09-30 00:00:00
abstract::In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90012-7
更新日期:1987-02-01 00:00:00
abstract::Changes in reduced folates upon exposure of Krebs ascites cells and L1210 murine leukemia cells to methotrexate (MTX) have been measured by stoichiometric entrapment of tissue methylenetetrahydrofolate into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2'-deoxy-uridine-5'-monophosphate. Tet...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90132-1
更新日期:1986-01-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is an aggressive and incurable mature B cell neoplasm. The current treatments are based on chemotherapeutics and new class of drugs (e.g. Ibrutinib(®)), which in most cases ends with tumor resistance and relapse. Therefore, further development of novel therapeutic modalities is needed. Exoso...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.04.026
更新日期:2015-08-01 00:00:00
abstract::Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90112-x
更新日期:1983-02-01 00:00:00
abstract::Telomerase plays an important role in the maintenance of telomere ends in normal and tumor cells and ectopic expression can immortalize human bronchial epithelial (HBE) cells. We assessed telomerase activation, growth properties and methylation status in the hTERT promoter in a panel of HBE cell cultures in relation t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.01.023
更新日期:2007-02-08 00:00:00
abstract::Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.05.012
更新日期:2017-08-28 00:00:00
abstract::The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarci...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90012-x
更新日期:1982-09-01 00:00:00
abstract::Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.020
更新日期:2017-01-01 00:00:00
abstract::VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In v...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.04.015
更新日期:2010-10-28 00:00:00
abstract::Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain met...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.07.001
更新日期:2011-12-08 00:00:00
abstract::Patients with hormone-receptor-positive early breast cancer have a significant risk of recurrence despite the use of adjuvant tamoxifen. The third-generation aromatase inhibitors letrozole, anastrozole, and exemestane offer promise as alternative or additional therapy to tamoxifen. As extended adjuvant therapy followi...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.07.002
更新日期:2007-04-18 00:00:00
abstract::Tobacco-specific N-nitrosamines (TSNA) are the most abundant carcinogens identified in tobacco and its smoke. Reducing their levels in tobacco products and especially in cigarette smoke is, therefore, a primary goal towards minimizing the carcinogenic burden of the tobacco consumer. This study delineates the mechanism...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90173-8
更新日期:1983-01-01 00:00:00
abstract::Expression of the cytoplasmic soluble form of p53 protein in the different rat colon cancer cell lines transfected and non-transfected with Rous sarcoma virus-33 was studied. Concentrations of the p53 protein were detected by commonly used immunochemical methods after its isolation by affinity chromatography columns w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00345-5
更新日期:1997-12-23 00:00:00
abstract::N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90053-1
更新日期:1980-10-01 00:00:00
abstract::The purpose of this study was to investigate the possible role of PI-3K/Akt2 pathway in docetaxel-induced apoptosis. Here we showed that transfection of full-length Akt2 into breast and ovarian cancer cells could provoke Akt phosphorylation and induce an enhanced resistance to docetaxel. FN adhesion promoted Akt phosp...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.11.022
更新日期:2008-03-08 00:00:00
abstract::Consumption of false morel (Gyromitra esculenta Fr.) has been associated not only with acute poisoning, but also with a carcinogenic risk. The hydrolysis of acetaldehyde-N-methyl-N-formylhydrazone (gyromitrin, the main toxic component of false morel) results in the formation of the methylating agents N-methyl-N-formyl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90175-u
更新日期:1992-01-10 00:00:00