Effect of continuous light on the incidence of 9,10-dimethyl-1,2-benzanthracene induced mammary tumors in female Holtzman rats.

Abstract:

:The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarcinoma was 95% in animals maintained in continuous photoperiod in contrast to that (60%) observed in control animals maintained on a light/dark (10/14 h) schedule. Further, the latency period of tumor appearance (61.5 +/- 9 days) in the former group was found to be significantly shorter than that seen in the latter group (93.7 +/- 8.3 days). Explanations are offered for this difference in the observed incidence.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Kothari LS,Shah PN,Mhatre MC

doi

10.1016/0304-3835(82)90012-x

subject

Has Abstract

pub_date

1982-09-01 00:00:00

pages

313-7

issue

3

eissn

0304-3835

issn

1872-7980

pii

0304-3835(82)90012-X

journal_volume

16

pub_type

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