Abstract：
:Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and the tumor microenvironment are being investigated. Some of these approaches, such as checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and BiTE antibodies, have achieved exciting outcomes in preclinical and clinical trials. The current review describes the roles of immune cells and the immunosuppressive microenvironment in the development of pancreatic cancer, as well as the preclinical and clinical outcomes and benefits of recent immunotherapeutic approaches, which may help us further disclose the mechanisms of pancreatic cancer progression and the dialectical views of feasibility and effectiveness of immunotherapy in treatment of pancreatic cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Xu JW,Wang L,Cheng YG,Zhang GY,Hu SY,Zhou B,Zhan HXdoi
10.1016/j.canlet.2018.03.040subject
Has Abstractpub_date
2018-07-01 00:00:00pages
143-151eissn
0304-3835issn
1872-7980pii
S0304-3835(18)30243-Xjournal_volume
425pub_type
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