当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Effect of Brussels sprouts on oxidative DNA-damage in man.

Effect of Brussels sprouts on oxidative DNA-damage in man.

Abstract：

:The effect of consumption of Brussels sprouts on the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) into human urine was investigated. Ten non-smoking volunteers (five males and five females) were randomly assigned to two groups. Five volunteers started on a diet of 300 g of glucosinolate-free vegetables whereas the other five consumed 300 g of Brussels sprouts per day. After 1 week dietary regimes were reversed. Levels of 8-oxodG in 24-h urine samples were measured by high-performance liquid chromatography. In four of five males a reduction in 8-oxodG was found, whereas in the fifth male the 8-oxodG excretion was high in the control period and was even much higher in the sprouts period. In females no effect of consumption of Brussels sprouts on excretion of 8-oxodG was found. Our previous and present findings support the results of epidemiologic studies that consumption of brassica vegetables may diminish cancer risk.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Verhagen H,de Vries A,Nijhoff WA,Schouten A,van Poppel G,Peters WH,van den Berg H

doi

10.1016/s0304-3835(97)04641-7

subject

Has Abstract

pub_date

1997-03-19 00:00:00

pages

127-30

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(97)04641-7

journal_volume

114

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CANCER LETTERS文献大全
  • The potential of long noncoding RNAs for precision medicine in human cancer.

    abstract：:Precision medicine promises to better classify patients by individual clinical and biological biomarkers, which may provide an accurate assessment of disease risk, diagnosis, prognosis and treatment response. Cancer frequently displays substantial inter-tumor and intra-tumor heterogeneity and hence oncology is well su...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.11.040

    authors： Wu M,Zhang X,Han X,Pandey V,Lobie PE,Zhu T

    更新日期：2021-03-31 00:00:00

  • Resveratrol is a potent inducer of apoptosis in human melanoma cells.

    abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00676-6

    authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

    更新日期：2003-02-20 00:00:00

  • Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.

    abstract：:The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00230-4

    authors： Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

    更新日期：1998-11-27 00:00:00

  • Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.

    abstract：:The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth an...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.04.040

    authors： Lee WY,Liu KW,Yeung JH

    更新日期：2009-11-18 00:00:00

  • Adipose tissue-derived mesenchymal stem cells cultured at high density express IFN-β and TRAIL and suppress the growth of H460 human lung cancer cells.

    abstract：:Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm2) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosis factor-related ap...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.10.017

    authors： Jung PY,Ryu H,Rhee KJ,Hwang S,Lee CG,Gwon SY,Kim J,Kim J,Yoo BS,Baik SK,Bae KS,Eom YW

    更新日期：2019-01-01 00:00:00

  • Small molecule BKM1972 inhibits human prostate cancer growth and overcomes docetaxel resistance in intraosseous models.

    abstract：:Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.01.010

    authors： Chen Y,Gera L,Zhang S,Li X,Yang Y,Mamouni K,Wu AY,Liu H,Kucuk O,Wu D

    更新日期：2019-04-01 00:00:00

  • Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia.

    abstract：:Cachexia, also known as wasting syndrome notably with skeletal muscle atrophy, costs nearly one-third of all cancer deaths in man. (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenolic component in green tea, is a potent preventive against cachexia as well as cancers. However, how EGCG counteracts cachexia...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.02.023

    authors： Wang H,Lai YJ,Chan YL,Li TL,Wu CJ

    更新日期：2011-06-01 00:00:00

  • Regulat-INGs in tumors and diseases: Focus on ncRNAs.

    abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.01.006

    authors： Gournay M,Paineau M,Archambeau J,Pedeux R

    更新日期：2019-04-10 00:00:00

  • The microcirculation in two transplantable melanomas of the hamster. I. In vivo observations in transparent chambers.

    abstract：:Twenty-eight transparent chambers were inserted into the cheek pouches of hamsters and daily serial observations made of the changing vasculature of transplants of 2 varieties (A-Mel-4B32, ZGYP1) of amelanotic melanomas. The tumor A-Mel-4B32 grew at a rate which covered 50% of the viewing area in 3--4 days, while the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)93797-7

    authors： Warren BA,Shubik P,Wilson R,Garcia H,Feldman R

    更新日期：1978-02-01 00:00:00

  • Enhancement of tumorigenesis by N-nitrosodiethylamine, N-nitrosopyrrolidine and N6-(methylnitroso)-adenosine by ethanol.

    abstract：:Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90220-4

    authors： Anderson LM,Carter JP,Driver CL,Logsdon DL,Kovatch RM,Giner-Sorolla A

    更新日期：1993-01-15 00:00:00

  • Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine.

    abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90175-8

    authors： De Flora S,Astengo M,Serra D,Bennicelli C

    更新日期：1986-09-01 00:00:00

  • On the formation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone during smoking.

    abstract：:Tobacco-specific N-nitrosamines (TSNA) are the most abundant carcinogens identified in tobacco and its smoke. Reducing their levels in tobacco products and especially in cigarette smoke is, therefore, a primary goal towards minimizing the carcinogenic burden of the tobacco consumer. This study delineates the mechanism...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90173-8

    authors： Adams JD,Lee SJ,Vinchkoski N,Castonguay A,Hoffmann D

    更新日期：1983-01-01 00:00:00

  • N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas.

    abstract：:N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles of Naa10p were reported in cancers. Here, we report an oncogenic role of Naa10p in promoting metastasis of osteosarcomas. Higher NAA10 transcripts were observed in metastatic osteosarcoma...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.06.033

    authors： Chien MH,Lee WJ,Yang YC,Tan P,Pan KF,Liu YC,Tsai HC,Hsu CH,Wen YC,Hsiao M,Hua KT

    更新日期：2018-10-01 00:00:00

  • Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel.

    abstract：:Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate canc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.10.006

    authors： Shen Z,Zhou L,Zhang C,Xu J

    更新日期：2020-01-01 00:00:00

  • DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention.

    abstract：:Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DNA repair genes. This includes biallelic germ-line mutations in the MUTYH gene, encoding a DNA glycosylase that is involved...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2008.02.032

    authors： Paz-Elizur T,Sevilya Z,Leitner-Dagan Y,Elinger D,Roisman LC,Livneh Z

    更新日期：2008-07-18 00:00:00

  • The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer.

    abstract：:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.11.030

    authors： Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

    更新日期：2004-03-31 00:00:00

  • MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth.

    abstract：:Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We succes...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.12.025

    authors： Xu Z,Wang Z,Jia X,Wang L,Chen Z,Wang S,Wang M,Zhang J,Wu M

    更新日期：2016-03-01 00:00:00

  • Histone deacetylase inhibitors that target tubulin.

    abstract：:Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone sub...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.01.040

    authors： Schemies J,Sippl W,Jung M

    更新日期：2009-08-08 00:00:00

  • Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice.

    abstract：:The pulmonary tumorigenicity of dimethylarsinic acid (DMAA), a main metabolite of inorganic arsenics, was examined in A/J mice fed with drinking water containing DMAA for 25 and 50 weeks. Mice fed with 400 ppm DMAA for 50 weeks produced more pulmonary tumors than untreated mice (mean number per animal 1.36 versus 0.50...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00484-9

    authors： Hayashi H,Kanisawa M,Yamanaka K,Ito T,Udaka N,Ohji H,Okudela K,Okada S,Kitamura H

    更新日期：1998-03-13 00:00:00

  • Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes.

    abstract：:Mantle cell lymphoma (MCL) is an aggressive and incurable mature B cell neoplasm. The current treatments are based on chemotherapeutics and new class of drugs (e.g. Ibrutinib(®)), which in most cases ends with tumor resistance and relapse. Therefore, further development of novel therapeutic modalities is needed. Exoso...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.04.026

    authors： Hazan-Halevy I,Rosenblum D,Weinstein S,Bairey O,Raanani P,Peer D

    更新日期：2015-08-01 00:00:00

  • Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer.

    abstract：:Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upre...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.04.013

    authors： Du H,Bay BH,Mahendran R,Olivo M

    更新日期：2006-04-28 00:00:00

  • Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes.

    abstract：:The three mistletoe (Viscum album L.) lectins. ML I, ML II and ML III, were tested on their ability to enhance the secretion of the cytokines tumor necrosis factor (TNF)alpha, interleukin (IL)-1 alpha, IL-1 beta and IL-6 by human monocytes obtained from healthy donors. At lectin concentrations from 0.02 to 20/pg ml (1...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04401-1

    authors： Ribéreau-Gayon G,Dumont S,Muller C,Jung ML,Poindron P,Anton R

    更新日期：1996-12-03 00:00:00

  • Targeted cancer immunotherapy with genetically engineered oncolytic Salmonella typhimurium.

    abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.10.033

    authors： Guo Y,Chen Y,Liu X,Min JJ,Tan W,Zheng JH

    更新日期：2020-01-28 00:00:00

  • Caffeine-derived N-nitroso compounds. IV: Kinetics of mononitrosocaffeidine demethylation by rat liver microsomes.

    abstract：:The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90071-x

    authors： Razdan R,Frei E,Spiegelhalder B,Siddiqi M

    更新日期：1994-04-29 00:00:00

  • Clinical management of third-generation EGFR inhibitor-resistant patients with advanced non-small cell lung cancer: Current status and future perspectives.

    abstract：:Discovery of activating mutations in epidermal growth factor receptor (EGFR) as a predictive biomarker for first-generation EGFR tyrosine kinase inhibitors (TKIs) has initiated an era of precision oncology for the treatment of advanced EGFR-mutant non-small cell lung cancer (NSCLC). Despite the robust efficacy of firs...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.05.044

    authors： Zhang YC,Zhou Q,Wu YL

    更新日期：2019-09-10 00:00:00

  • Sulofenur cytotoxicity and changes in cytosolic calcium and mitochondrial membrane potential in human colon adenocarcinoma cell lines.

    abstract：:Sulofenur treatment (12.5 microM-1 mM) of colon adenocarcinoma cell lines resulted in dose- and time-dependent cell killing. LYc5 cells were viable longer than GC3/c1 cells. Each concentration resulted in elevation of cytosolic calcium [Ca2+]i) for both cell lines. At lower doses, elevation was delayed for LYc5 cells....

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)03607-k

    authors： Phelps PC,Jain PT,Berezesky IK,Boder GB,Trump BF

    更新日期：1995-01-06 00:00:00

  • Mechanistic study of the inhibition of aflatoxin b1-induced hepatotoxicity by dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2, 2'-dicarboxylate.

    abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03688-s

    authors： Liu TY,Hwua YS,Chao TW,Chi CW

    更新日期：1995-03-02 00:00:00

  • The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis.

    abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.041

    authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

    更新日期：2006-07-08 00:00:00

  • Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.

    abstract：:Microsomes isolated from hyperplastic liver nodules and hepatomas, induced by DL-ethionine, exhibited a reduced cytochrome P-450 content and aminopyrine N-demethylase activity when compared to the organelles of control and surrounding non-nodular liver. Phenobarbital administration to rats caused an increase of micros...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)80006-8

    authors： Feo F,Canuto RA,Garcea R,Brossa O,Caselli GC

    更新日期：1978-07-01 00:00:00

  • Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.

    abstract：:Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.06.020

    authors： Rho SB,Byun HJ,Park SY,Chun T

    更新日期：2008-11-28 00:00:00