Abstract:
:The pulmonary tumorigenicity of dimethylarsinic acid (DMAA), a main metabolite of inorganic arsenics, was examined in A/J mice fed with drinking water containing DMAA for 25 and 50 weeks. Mice fed with 400 ppm DMAA for 50 weeks produced more pulmonary tumors than untreated mice (mean number per animal 1.36 versus 0.50; P < 0.05). Histological examination revealed that the number of mice which bore adenocarcinomas or papillary adenomas correlated with the concentration of DMAA given (untreated versus 400 ppm; P = 0.002), suggesting that DMAA could promote tumorigenic processes. These results are consistent with the epidemiological studies on the pulmonary carcinogenesis of arsenics and suggest that DMAA alone can act as a carcinogen in mice.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hayashi H,Kanisawa M,Yamanaka K,Ito T,Udaka N,Ohji H,Okudela K,Okada S,Kitamura Hdoi
10.1016/s0304-3835(97)00484-9subject
Has Abstractpub_date
1998-03-13 00:00:00pages
83-8issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(97)00484-9journal_volume
125pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04104-4
更新日期:1996-02-06 00:00:00
abstract::In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inh...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90097-s
更新日期:1993-07-30 00:00:00
abstract::Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.12.023
更新日期:2007-08-28 00:00:00
abstract::Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylase inhibitors (HDACi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.04.023
更新日期:2017-08-01 00:00:00
abstract::Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2. Here, we showed tha...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.002
更新日期:2015-02-01 00:00:00
abstract::To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00276-0
更新日期:1998-01-16 00:00:00
abstract::The nuclear transcription factor kappaB (NF-kappaB) plays an important role in the development and progression of cancers. However, the mechanism by which cancer cells in the head and neck region acquire high NF-kappaB activity has not yet been clarified. In this study, we examined the NF-kappaB binding activity and t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00611-5
更新日期:2001-10-10 00:00:00
abstract::The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90249-u
更新日期:1992-10-21 00:00:00
abstract::Macrophages that infiltrate tumor tissues, or tumor-associated macrophages (TAMs), affect the malignant behaviors of tumor cells. In this study, we attempted to induce monocytes to differentiate into TAM-like cells producing matrix metalloproteinases (MMPs) by co-culture with tumor cells. When human monocytes were co-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.09.029
更新日期:2012-02-28 00:00:00
abstract::Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:
更新日期:1996-01-02 00:00:00
abstract::Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.10.027
更新日期:2005-06-01 00:00:00
abstract::ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.01.006
更新日期:2019-04-10 00:00:00
abstract::Sulofenur treatment (12.5 microM-1 mM) of colon adenocarcinoma cell lines resulted in dose- and time-dependent cell killing. LYc5 cells were viable longer than GC3/c1 cells. Each concentration resulted in elevation of cytosolic calcium [Ca2+]i) for both cell lines. At lower doses, elevation was delayed for LYc5 cells....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)03607-k
更新日期:1995-01-06 00:00:00
abstract::Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04407-2
更新日期:1996-10-01 00:00:00
abstract::Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)80022-0
更新日期:1977-03-01 00:00:00
abstract::Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00090-1
更新日期:1998-07-03 00:00:00
abstract::Gastric juice samples of 71 patients undergoing upper gastrointestinal endoscopy were collected as well as saliva samples from 40 of these patients. Age, sex, endoscopic diagnosis and medication were recorded. The gastric juice samples were analyzed for the presence and quantity of individual volatile N-nitrosamines, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00467-9
更新日期:1998-02-27 00:00:00
abstract::Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.07.042
更新日期:2014-12-28 00:00:00
abstract::Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root, Glycyrrhiza uralensis (G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MC...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.12.038
更新日期:2005-12-18 00:00:00
abstract::We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.01.019
更新日期:2007-08-08 00:00:00
abstract::Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00844-8
更新日期:2002-04-25 00:00:00
abstract::Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90220-4
更新日期:1993-01-15 00:00:00
abstract::Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.04.032
更新日期:2019-08-01 00:00:00
abstract::The cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C) in combination with hydroxyurea (HU) or 2'-deoxyguanosine (GdR) on human gastric carcinoma MK-1 cells and colon carcinoma HT-15 cells was studied. Synergistic interaction between ara-C and HU on MK-1 cells and HT-15 cells, or ara-C and GdR on MK-1 cells was...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90264-v
更新日期:1992-04-30 00:00:00
abstract::Mutation of the p53 gene has been reported in hepatocellular carcinoma (HCC) occurring worldwide. The most frequent p53 mutation has been found in HCCs in regions with high hepatitis B virus (HBV) infection and intake of aflatoxin B1 (AFB1). The aim of our study was to examine p53 protein expression in HCCs from a hig...
journal_title:Cancer letters
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3835(97)00352-2
更新日期:1997-12-23 00:00:00
abstract::PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90151-2
更新日期:1980-02-01 00:00:00
abstract::Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90047-1
更新日期:1981-03-01 00:00:00
abstract::Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund-Wistar rats were exposed...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00811-4
更新日期:2002-12-01 00:00:00
abstract::Emerging evidence indicates that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence, and therapeutic resistance in hepatocellular carcinoma (HCC). However, the mechanisms underlying HCC CSC regulation remain largely unknown. Here we report our analysis of 97 paraffin-embedded HCC tumor specimens....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.02.040
更新日期:2019-05-28 00:00:00
abstract::In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90012-7
更新日期:1987-02-01 00:00:00