MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.

abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...

journal_title：Cancer letters

authors： He Z,Wu J,Dang H,Lin H,Zheng H,Zhong D

更新日期：2011-04-28 00:00:00

abstract：:The susceptibility of analbuminemic rats, a mutant strain of Sprague-Dawley rats, to bladder carcinogens was examined by testing the agglutinability of isolated bladder epithelial cells by Concanavalin A (Con A). One-week treatment with 0.001% N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN) in the drinking water or 0.01%...

journal_title：Cancer letters

authors： Honma Y,Kakizoe T,Komatsu H,Niijima T,Sugimura T,Nagase S

更新日期：1983-05-01 00:00:00

abstract：:Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene located on chromosome 22...

journal_title：Cancer letters

authors： Manda R,Kohno T,Hamada K,Takenoshita S,Kuwano H,Yokota J

更新日期：2000-05-29 00:00:00

abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

journal_title：Cancer letters

authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

更新日期：1996-01-02 00:00:00

abstract：:Although the incidence is very low, the prognosis of anaplastic carcinoma of the thyroid is very poor regardless of the results of various therapeutic trials. We found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of the mdr1 and...

journal_title：Cancer letters

authors： Sugawara I,Arai T,Yamashita T,Yoshida A,Masunaga A,Itoyama S

更新日期：1994-07-29 00:00:00

abstract：:Expression of cyclooxygenase (COX)-2 protein in preneoplastic and neoplastic lung lesions induced by the administration of 2000 ppm of N-nitrosobis(2-hydroxypropyl)amine (BHP) in the drinking water to Wistar male rats, was examined immunohistochemically. The majority of alveolar/bronchiolar adenomas (ADs) and all aden...

journal_title：Cancer letters

authors： Kitayama W,Denda A,Yoshida J,Sasaki Y,Takahama M,Murakawa K,Tsujiuchi T,Tsutsumi M,Konishi Y

更新日期：2000-02-01 00:00:00

abstract：:A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...

journal_title：Cancer letters

authors： Grosso LE,Pitot HC

更新日期：1984-02-01 00:00:00

abstract：:We have developed an epithelial cell line derived from mouse liver which represents a spectrum of malignant progression. When inoculated into mice at low passage, the cells induced benign cysts; after extensive subcultures, the same line induced low grade adenocarcinomas. A variant of these cells with increased invasi...

journal_title：Cancer letters

authors： Dollbaum CM,Anderson LW,Smith HS

更新日期：1980-12-01 00:00:00

abstract：:Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...

journal_title：Cancer letters

authors： Dogra S,Bandi S,Viswanathan P,Gupta S

更新日期：2015-01-28 00:00:00

abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

journal_title：Cancer letters

authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

更新日期：2013-10-10 00:00:00

abstract：:Breast cancer stem cells (BCSCs) initiate and sustain breast cancers, and several putative markers have been proposed to prospectively isolate BCSC from the non-cancer stem cell population. The candidate BCSC marker Sca-1 is a GPI-linked membrane protein expressed on activated lymphocytes, hematopoietic stem cells and...

journal_title：Cancer letters

authors： Matilainen H,Yu XW,Tang CW,Berridge MV,McConnell MJ

更新日期：2012-10-01 00:00:00

abstract：:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently...

journal_title：Cancer letters

authors： Zunft HJ,Goldin-Lang P,Dongowski G

更新日期：1997-03-19 00:00:00

abstract：:Pancreatic cancer is the most lethal tumor. CA125 (gene symbol MUC16) is an important serum marker for pancreatic cancer diagnosis and treatment. High serum CA125 is related to metabolic tumor burden and poor prognosis. The circulating Treg subset is another independent prognostic factor for pancreatic cancer. Our unp...

journal_title：Cancer letters

authors： Fan K,Yang C,Fan Z,Huang Q,Zhang Y,Cheng H,Jin K,Lu Y,Wang Z,Luo G,Yu X,Liu C

更新日期：2018-04-01 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:Transcriptional factor BTB and CNC homology 1 (Bach1) has been linked to tumor progression and metastasis, but the mechanisms underlying the effects of Bach1 on tumor growth and metastasis are largely uncharacterized. Here, we report that Bach1 expression was significantly higher in human epithelial ovarian cancer (EO...

journal_title：Cancer letters

authors： Han W,Zhang Y,Niu C,Guo J,Li J,Wei X,Jia M,Zhi X,Yao L,Meng D

更新日期：2019-03-31 00:00:00

abstract：:By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

journal_title：Cancer letters

authors： Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

更新日期：2008-07-08 00:00:00

abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

journal_title：Cancer letters

authors： Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

更新日期：2002-09-08 00:00:00

abstract：:Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose...

journal_title：Cancer letters

authors： Emminger A,Kahmann E,Savage DS

更新日期：1977-03-01 00:00:00

abstract：:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...

journal_title：Cancer letters

authors： Gatouillat G,Odot J,Balasse E,Nicolau C,Tosi PF,Hickman DT,López-Deber MP,Madoulet C

更新日期：2007-11-18 00:00:00

abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...

journal_title：Cancer letters

authors： Kuo CL,Chi CW,Liu TY

更新日期：2004-01-20 00:00:00

abstract：:Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...

journal_title：Cancer letters

authors： Yokozaki H,Ito R,Ono S,Hayashi K,Tahara E

更新日期：1999-06-01 00:00:00

abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

更新日期：1999-07-19 00:00:00

abstract：:The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...

journal_title：Cancer letters

authors： Thongsuksai P,Boonyaphiphat P,Sriplung H,Sudhikaran W

更新日期：2003-11-10 00:00:00

abstract：:Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. par...

journal_title：Cancer letters

authors： Shah SA

更新日期：1985-03-01 00:00:00

abstract：:In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cel...

journal_title：Cancer letters

authors： Leung LK,Do L,Wang TT

更新日期：1998-02-13 00:00:00

abstract：:Prostate cancer urgently needs an efficient therapy. Here we demonstrated that cisplatin combined with gene therapy by transfecting the attenuated Salmonella that carry a plasmid containing p53 gene and MDM2 siRNA provided a super-synergistic effect on the inhibition of prostate cancer growth in vivo. This synergistic...

journal_title：Cancer letters

authors： Jiang T,Zhou C,Gu J,Liu Y,Zhao L,Li W,Wang G,Li Y,Cai L

更新日期：2013-08-28 00:00:00

abstract：:The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor spheroids. In neuroblastoma spheroids, the combination of cisplatin and gemcitabine induced a complete cytostasis at clinical relevant concentrations. A synergistic effect ...

journal_title：Cancer letters

authors： Besançon OG,Tytgat GA,Meinsma R,Leen R,Hoebink J,Kalayda GV,Jaehde U,Caron HN,van Kuilenburg AB

更新日期：2012-06-01 00:00:00

abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

journal_title：Cancer letters

authors： Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

更新日期：2013-07-01 00:00:00

abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...

journal_title：Cancer letters

authors： Sang M,Wang L,Ding C,Zhou X,Wang B,Wang L,Lian Y,Shan B

更新日期：2011-03-28 00:00:00

abstract：:Irradiation with 90Sr-90Y beta rays induced ornithine decarboxylase (ODC) activity in mouse skin. Maximum activity appeared after about 17 days, at the time of appearance of skin injuries. These findings suggest the presence of tumor-promoting activity of beta rays. ...

journal_title：Cancer letters

authors： Fujiki H,Mori M,Tanooka H

更新日期：1982-01-01 00:00:00