Abstract:
:We have developed an epithelial cell line derived from mouse liver which represents a spectrum of malignant progression. When inoculated into mice at low passage, the cells induced benign cysts; after extensive subcultures, the same line induced low grade adenocarcinomas. A variant of these cells with increased invasive and metastatic potential was selected. In culture, growth in methocel correlated with acquisition of malignant potential while increased homotypic aggregation correlated with metastatic ability. These cultures should be extremely valuable for studies on the nature of epithelial cell malignancy, the most common form of human cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Dollbaum CM,Anderson LW,Smith HSdoi
10.1016/0304-3835(80)90102-0subject
Has Abstractpub_date
1980-12-01 00:00:00pages
121-7issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(80)90102-0journal_volume
11pub_type
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