Abstract:
:The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence of a metabolic activation system while (II) was highly mutagenic when tested directly. This is the first report on the conversion of a non-mutagenic N-nitrosamine to a mutagen by the formation of an alpha-acetoxy derivative.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jacobson MK,Barton RA,Yoder SS,Sigh S,Lyle REdoi
10.1016/s0304-3835(79)80005-1subject
Has Abstractpub_date
1979-02-01 00:00:00pages
83-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(79)80005-1journal_volume
6pub_type
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