Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors.

abstract：:The pulmonary tumorigenicity of dimethylarsinic acid (DMAA), a main metabolite of inorganic arsenics, was examined in A/J mice fed with drinking water containing DMAA for 25 and 50 weeks. Mice fed with 400 ppm DMAA for 50 weeks produced more pulmonary tumors than untreated mice (mean number per animal 1.36 versus 0.50...

journal_title：Cancer letters

authors： Hayashi H,Kanisawa M,Yamanaka K,Ito T,Udaka N,Ohji H,Okudela K,Okada S,Kitamura H

更新日期：1998-03-13 00:00:00

abstract：:Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...

journal_title：Cancer letters

authors： Yoshimoto M,Tsutsumi M,Iki K,Sasaki Y,Tsujiuchi T,Sugimura T,Wakabayashi K,Konishi Y

更新日期：1999-09-01 00:00:00

abstract：:Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique. We review the onc...

journal_title：Cancer letters

authors： Matsuzawa A,Nakano H,Yoshimoto T,Sayama K

更新日期：1995-03-23 00:00:00

abstract：:In order to search for the direct evidence of cellular response to low-dose radiation, we investigated wild-type p53 protein accumulation in several organs of mice after exposure to low doses of X-rays. Significant p53 accumulation within 24 h was observed in the mouse adrenal glands and pancreas after X-ray irradiati...

journal_title：Cancer letters

authors： Wang X,Matsumoto H,Takahashi A,Nakano T,Okaichi K,Ihara M,Ohnishi T

更新日期：1996-06-24 00:00:00

abstract：:To investigate whether particular patterns of food consumption are related to the occurrence of breast and colon cancer, two simultaneous case-control studies of French-Canadians with 616 cases (414 breast cancer, 202 colon cancer) and 429 population-based controls were carried out. Food consumption data were obtained...

journal_title：Cancer letters

authors： Nkondjock A,Ghadirian P

更新日期：2005-06-01 00:00:00

abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

更新日期：1999-07-19 00:00:00

abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...

journal_title：Cancer letters

authors： De Preter K,Vandesompele J,Heimann P,Kockx MM,Van Gele M,Hoebeeck J,De Smet E,Demarche M,Laureys G,Van Roy N,De Paepe A,Speleman F

更新日期：2003-07-18 00:00:00

abstract：:We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%)...

journal_title：Cancer letters

authors： Iolascon A,Lo Cunsolo C,Giordani L,Cusano R,Mazzocco K,Boumgartner M,Ghisellini P,Faienza MF,Boni L,De Bernardi B,Conte M,Romeo G,Tonini GP

更新日期：1998-08-14 00:00:00

abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...

journal_title：Cancer letters

authors： Nesnow S,Triplett LL,Slaga TJ

更新日期：1984-05-01 00:00:00

abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

journal_title：Cancer letters

authors： Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

更新日期：2013-07-01 00:00:00

abstract：:Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...

journal_title：Cancer letters

authors： Janouskova H,Ray AM,Noulet F,Lelong-Rebel I,Choulier L,Schaffner F,Lehmann M,Martin S,Teisinger J,Dontenwill M

更新日期：2013-08-19 00:00:00

abstract：:The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...

journal_title：Cancer letters

authors： Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

更新日期：2015-12-01 00:00:00

abstract：:Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing. Male Fischer 344 rats, 6 weeks old...

journal_title：Cancer letters

authors： Tsujiuchi T,Kido A,Nakae D,Takahama M,Majima T,Kobitsu K,Okajima E,Tsutsumi M,Denda A,Konishi Y

更新日期：1996-11-12 00:00:00

abstract：:Okadaic acid, a potent tumor promoter and an inhibitor of protein phosphatase 1 and 2A, has also been characterized as an angiogenic inducer in the chorioallantoic membrane of the chick embryo. To elucidate the roles of okadaic acid on angiogenic processes, we conducted in vitro angiogenesis assays. In this study, we ...

journal_title：Cancer letters

authors： Kim YS,Ahn KH,Kim SY,Jeong JW

更新日期：2009-04-08 00:00:00

abstract：:In order to characterize the enzymes involved in the purine nucleotide catabolism as indicators of invasiveness and aggressiveness of malignant gliomas, the degradation of extracellular nucleotides by five different glioma cell lines was investigated and compared with primary astrocytes. Rapid hydrolysis of extracellu...

journal_title：Cancer letters

authors： Wink MR,Lenz G,Braganhol E,Tamajusuku AS,Schwartsmann G,Sarkis JJ,Battastini AM

更新日期：2003-08-20 00:00:00

abstract：:The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...

journal_title：Cancer letters

authors： Thongsuksai P,Boonyaphiphat P,Sriplung H,Sudhikaran W

更新日期：2003-11-10 00:00:00

abstract：:The effect of vitamin A (retinyl acetate) on lung tumor development in strain A mice exposed to radiation was assessed. Four groups of 75 mice were utilized. Two groups were fed a low vitamin A diet (less than 100 IU/100 g diet) and the other 2 were fed a high vitamin A diet (800 IU/100 g diet). After 2 weeks one grou...

journal_title：Cancer letters

authors： Mian TA,Theiss JC,Gesell TF

更新日期：1984-02-01 00:00:00

abstract：:Protein kinase C epsilon (PKCε), a member of the novel PKC family, is known to be a transforming oncogene and tumor biomarker for many human solid cancers including renal cell carcinoma (RCC). We isolated side population (SP) cells from the RCC 769P cell line, and proved that those cells possess cancer stem cell (CSC)...

journal_title：Cancer letters

authors： Huang B,Fu SJ,Fan WZ,Wang ZH,Chen ZB,Guo SJ,Chen JX,Qiu SP

更新日期：2016-06-28 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...

journal_title：Cancer letters

authors： Chaudhuri PK,Thomas PA,Walker MJ,Briele HA,Das Gupta TK,Beattie CW

更新日期：1982-09-01 00:00:00

abstract：:Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center...

journal_title：Cancer letters

authors： dos Santos MA,Borges JB,de Almeida DC,Curi R

更新日期：2004-12-28 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

journal_title：Cancer letters

authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

更新日期：2011-12-26 00:00:00

abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...

journal_title：Cancer letters

authors： Burnett JP,Lim G,Li Y,Shah RB,Lim R,Paholak HJ,McDermott SP,Sun L,Tsume Y,Bai S,Wicha MS,Sun D,Zhang T

更新日期：2017-05-28 00:00:00

abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

journal_title：Cancer letters

authors： Miyata Y,Fukushima S,Imaida K,Ito N

更新日期：1984-07-01 00:00:00

abstract：:The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that these expectations remain unfulfilled. Mutations in BRCA1 and BRCA2 ...

journal_title：Cancer letters

authors： Schwab M,Claas A,Savelyeva L

更新日期：2002-01-10 00:00:00

abstract：:Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...

journal_title：Cancer letters

authors： Baxt WG

更新日期：1994-03-15 00:00:00

abstract：:The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosusp...

journal_title：Cancer letters

authors： Zheng D,Wang Y,Zhang D,Liu Z,Duan C,Jia L,Wang F,Liu Y,Liu G,Hao L,Zhang Q

更新日期：2011-08-28 00:00:00

abstract：:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...

journal_title：Cancer letters

authors： Martens U,Lennartsson P,Högberg J,Stenius U

更新日期：1996-06-24 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments ineffective. The emergence of single-cell genomics represents a powerful strategy in delineating the complex molecular landscapes of cancers. In this study, we demonstrated the feasibility and merit of using single-cell RNA sequ...

journal_title：Cancer letters

authors： Ho DW,Tsui YM,Sze KM,Chan LK,Cheung TT,Lee E,Sham PC,Tsui SK,Lee TK,Ng IO

更新日期：2019-09-10 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00