Abstract:
:Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center>periphery>mammary gland. Insulin caused a marked increase of glucose consumption and lactate production by incubated slices of mammary gland but had no effect on both microregions of the tumor. Therefore, human breast cancer presents metabolic microregions.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
dos Santos MA,Borges JB,de Almeida DC,Curi Rdoi
10.1016/j.canlet.2004.04.018keywords:
subject
Has Abstractpub_date
2004-12-28 00:00:00pages
243-8issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(04)00367-2journal_volume
216pub_type
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