Metabolism of the microregions of human breast cancer.

Abstract:

:Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center>periphery>mammary gland. Insulin caused a marked increase of glucose consumption and lactate production by incubated slices of mammary gland but had no effect on both microregions of the tumor. Therefore, human breast cancer presents metabolic microregions.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

dos Santos MA,Borges JB,de Almeida DC,Curi R

doi

10.1016/j.canlet.2004.04.018

keywords:

subject

Has Abstract

pub_date

2004-12-28 00:00:00

pages

243-8

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(04)00367-2

journal_volume

216

pub_type

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