Abstract：
:In order to search for the direct evidence of cellular response to low-dose radiation, we investigated wild-type p53 protein accumulation in several organs of mice after exposure to low doses of X-rays. Significant p53 accumulation within 24 h was observed in the mouse adrenal glands and pancreas after X-ray irradiation at 25 cGy and 50 cGy, but not at 100 cGy. In addition, differential p53 accumulation was also observed in the hypophysis, thymus, skin, lung, bone marrow and liver at different doses. In contrast, we observed no accumulation of p53 protein in the spleen, testis or kidney at any dose used in this experiment. The p53 accumulation induced by low-dose X-rays in mice was organ-specific. It is suggested that cell type and interactions with other signal transduction pathways of the hormone system, immune system and/or nervous system may contribute to the variable induction of p53 by low-dose X-ray irradiation. The association of organ-specific p53 response with radiosensitivity and cancer incidence by radiation in each organ was discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang X,Matsumoto H,Takahashi A,Nakano T,Okaichi K,Ihara M,Ohnishi Tdoi
10.1016/0304-3835(96)04235-8subject
Has Abstractpub_date
1996-06-24 00:00:00pages
79-84issue
1eissn
0304-3835issn
1872-7980pii
0304383596042358journal_volume
104pub_type
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