Abstract:
:The guinea pig Kurloff cell (KC) is an estradiol-dependent circulating mononuclear cell that had natural killer cytotoxic activity in vitro. We studied the variation of KC number during the development of transplanted leukemia in inbred strain 2 (S2) leukemia-sensitive guinea pigs. Grafts of leukemic cells (L2C) produced a significant increase in the number of KC. Leukemia occurred in 35.5% of non-estrogenized animals and in 18.3% of estrogenized guinea pigs. The increased number of KC seems to have antileukemia activity in vivo. This could be part of the general phenomenon of cancer resistance in guinea pigs.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Debout C,Taouji S,Izard Jdoi
10.1016/0304-3835(95)03960-5subject
Has Abstractpub_date
1995-10-20 00:00:00pages
117-22issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(95)03960-5journal_volume
97pub_type
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