Abstract:
:The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low concentration of PG490. CI-isobologram indicated that the effect of PG490 plus 5-FU was synergistic. PG490 and 5-FU treatment induced activated caspase 3 and Bax expression and inhibited Bcl-2 expression. PG490 simultaneously induced generation of reactive oxygen species (ROS) and inhibited NF-kappaB transcriptional activity.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Xu B,Guo X,Mathew S,Armesilla AL,Cassidy J,Darling JL,Wang Wdoi
10.1016/j.canlet.2009.10.013subject
Has Abstractpub_date
2010-05-28 00:00:00pages
200-8issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00635-1journal_volume
291pub_type
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