Abstract:
:The carcinogenic effect of ultraviolet radiation (UVR) on the skin of hairless (hr) mice was modified by two immunosuppressive agents, rabbit anti-mouse lymphocytic serum (ALS), and 6-mercaptopurine (6MP). Daily exposure of mice to UVR resulted in multiple tumor production. Carcinogenesis was measured in terms of affected mice (prevalence) and numbers of tumors produced. By both criteria, photocarcinogenesis was enhanced by ALS but inhibited by 6MP.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Nathanson RB,Forbes PD,Urbach Fdoi
10.1016/s0304-3835(75)97305-xkeywords:
subject
Has Abstractpub_date
1976-05-01 00:00:00pages
243-7issue
5eissn
0304-3835issn
1872-7980pii
S0304-3835(75)97305-Xjournal_volume
1pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and re...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.01.034
更新日期:2020-04-10 00:00:00
abstract::The retinoblastoma (Rb) gene is associated with the pathogenesis of several types of human cancer, including retinoblastoma, osteosarcoma, soft tissue sarcomas, and lung, breast and bladder carcinomas. Loss of heterozygosity is a common mode in allelic inactivation of Rb and other tumor-suppressor genes. We investigat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90099-u
更新日期:1993-07-30 00:00:00
abstract::Malachite green (MG), an industrial compound and potential environmental health hazard, is highly cytotoxic to mammalian cells in culture. In an attempt to define the biochemical basis, we have compared the cytotoxic effects and morphological alterations shown by MG in Syrian hamster embryo (SHE) cells with the levels...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90131-e
更新日期:1992-12-24 00:00:00
abstract::Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03835-k
更新日期:1995-07-20 00:00:00
abstract::The faithful inheritance of chromosomes is essential for the propagation of organisms. In eukaryotes, central to this process is the mitotic spindle. Recently, we have identified TRIM8 as a gene aberrantly expressed in gliomas whose expression reduces the clonogenic potential in the patients' glioma cells. TRIM8 encod...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.12.042
更新日期:2020-03-31 00:00:00
abstract::Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04407-2
更新日期:1996-10-01 00:00:00
abstract::The highly conserved RNA-binding protein, Lin28, is involved in many biological processes, including development, reprogramming, pluripotency, and metabolism. Importantly, Lin28 functions as an oncogene, promoting tumor progression and metastasis in various human cancers. Lin28 can regulate gene expression either by d...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.02.050
更新日期:2016-05-28 00:00:00
abstract::The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swoll...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04538-7
更新日期:1997-01-01 00:00:00
abstract::Three sections of brain tissue from 2,657 female C57BL/6 mice were stained with hematoxylin and eosin and evaluated microscopically for proliferative lesions. Mice had been treated with either split-dose ionizing radiation (0, 3.0, 4.0 and 5.1 Gy), chronic lifetime 60 Hz circularly polarized magnetic field exposure (a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00286-4
更新日期:1999-12-01 00:00:00
abstract::We aimed to clarify the clinical significance of des-gamma-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00539-5
更新日期:2000-10-16 00:00:00
abstract::Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.05.014
更新日期:2014-08-28 00:00:00
abstract::We demonstrate herein the ability of transforming growth factor-beta-2 (TGFbeta2) to potently activate extracellular signal-regulated kinase 2 (ERK2) in the highly TGFbeta-sensitive breast cancer cell (BCC) line Hs578T. The ERK2 isoform was activated by 3-fold within 5 min of TGFbeta2 addition to Hs578T cells. However...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00211-5
更新日期:1997-07-15 00:00:00
abstract::Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90096-5
更新日期:1994-03-15 00:00:00
abstract::Zinc finger transcription factors are DNA-binding proteins that are known to determine the identity of cells by regulating cell-specific gene expression. In addition, mutations in some members of this family have been found to be associated with several neoplasias, including Wilms' tumor and leukemias. Because the mec...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04204-8
更新日期:1996-06-05 00:00:00
abstract::The capacity of enteric bacteria (E. coli, Salmonella, Pseudomonas, Shigella and Klebsiella) to catalyze the covalent binding of benzo(a)pyrene (BP), cholic acid, deoxycholic acid and cholesterol was investigated. In general, these bacteria were incapable of activating BP to a covalently bound product with calf thymus...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)94577-3
更新日期:1977-07-01 00:00:00
abstract::Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.03.019
更新日期:2011-08-01 00:00:00
abstract::The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90249-2
更新日期:1988-09-01 00:00:00
abstract::Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.06.029
更新日期:2011-11-28 00:00:00
abstract::We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90323-9
更新日期:1994-08-15 00:00:00
abstract::We used selective biochemical markers of effect to evaluate some non-genotoxic cocarcinogenic properties of methyl thiophanate (MTH) associated with cytochrome P450 (CYP) changes. Several CYP-dependent reactions were monitored in the liver, kidney and lung microsomes of male and female Sprague-Dawley rats treated (i.p...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00298-5
更新日期:1999-01-29 00:00:00
abstract::Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90013-4
更新日期:1988-06-15 00:00:00
abstract::In a comparative experimental study, excisions of a transplanted Lewis lung carcinoma in BDF1 mice were performed by means of the CO2 laser and conventional methods, namely common scalpel and diathermy. The results showed a significant reduction in tumor recurrence and animal mortality rates (27.5% vs. 75% and 45%) af...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(76)80009-2
更新日期:1976-09-01 00:00:00
abstract::Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.019
更新日期:2004-09-30 00:00:00
abstract::Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP3 correlate with each other. Herein, we demonstrated that c-Met expression in gastric cancer tissues significantly correlated wit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.12.040
更新日期:2012-06-01 00:00:00
abstract::HER2 positive breast cancers have been shown to have a greater propensity to metastasise to the brain. This may be due to several reasons, including the creation of a "sanctuary-site" for tumour in the brain following trastuzumab therapy. Elucidating the mechanism of this phenomenon may aid the prevention or intervent...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.12.026
更新日期:2015-03-28 00:00:00
abstract::Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90239-r
更新日期:1992-08-31 00:00:00
abstract::In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00406-7
更新日期:2000-07-03 00:00:00
abstract::The influence of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a mutagen in chlorinated water, on cell proliferation and lipid peroxidation in the glandular stomach mucosa was investigated in male 4-week-old Wistar rats. Animals were given 50 p.p.m., 25 p.p.m., 12.5 p.p.m., 6.25 p.p.m. or 0 p.p.m. of MX soluti...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90268-2
更新日期:1994-10-14 00:00:00
abstract::Current in vivo investigations of tumor angiogenesis mainly rely on the results obtained from engrafted models in mice. In the present study, we attempt to assess the potential of human tumor endothelium to form neovasculature in different engrafted tumor models. The tumor endothelial cells were isolated from human es...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.12.015
更新日期:2007-07-08 00:00:00
abstract::Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.10.016
更新日期:2009-03-08 00:00:00