Abstract:
:Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR mice, while DMBA initiation alone and DAG treatment without DMBA initiation did not induce any skin tumors. Doubling the daily treatment (twice a day x 5 days/week) at doses of 75 and 30 mg caused both papillomas and squamous cell carcinomas after DMBA initiation, the incidences of tumors being 48% (12/25) and 44% (11/25), respectively, significantly higher than the 4% (1/23) in the DMBA+ 85 mg triacylglycerol group and 0% (0/24) in the DMBA+ vehicle-treated group. The results indicate that DAG-rich oil has promoting potential for skin carcinogenesis, and thus, further investigations of its tumor-promoting potential in other organs are warranted.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Takasuka N,Takahashi M,Hori Y,Kitahashi T,Iigo M,Imai T,Yoshimi N,Sugimura T,Wakabayashi Kdoi
10.1016/j.canlet.2008.10.016subject
Has Abstractpub_date
2009-03-08 00:00:00pages
150-7issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00815-Xjournal_volume
275pub_type
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