Abstract:
:The inhibitory effects of some scavengers of oxygen radicals were studied, using a two-stage transformation assay system in vitro 3-methylcholanthrene (3-MC)-initiation and 12-O-tetradecanoylphorbol-13-acetate-(TPA)-promotion in Balb 3T3 cells. Mannitol, a scavenger for hydroxyl radicals, strongly inhibited the TPA-enhanced transformation in a dose-dependent manner. Superoxide dismutase (SOD) and catalase, which are specific scavengers for O2-. and H2O2, respectively, also inhibited the transformation. These results suggest that oxygen radicals may play an important role in the TPA-enhanced transformation in Balb 3T3 cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Saito M,Tanaka N,Ohkawa Y,Inui Ndoi
10.1016/0304-3835(87)90041-3subject
Has Abstractpub_date
1987-05-01 00:00:00pages
167-71issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(87)90041-3journal_volume
35pub_type
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