当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia.

High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia.

Abstract：

:Microarray analysis is a powerful technology, but its impact on routine diagnosis for the near future maybe in revealing individual genes, which are useful diagnostic markers. Recently microarray analysis has identified a novel subgroup of childhood precursor-B acute lymphoblastic leukaemia (ALL) from a unique gene expression profile of over 30 genes. We have evaluated the four most highly expressed genes from this profile, by quantitative real time RT-PCR, to determine whether any of these genes by itself could be useful as a diagnostic indicator. The levels of expression of N-acetylglucosamine-6-O-sulfotransferase (GN6ST), protein tyrosine phosphatase receptor M (PTPRmu), G protein-coupled receptor 49 (HG38) and KIAA1099 protein were determined in childhood precursor-B ALL samples from a cohort of 116 Indian patients. In nine cases, three or four of these genes exhibited very high expression levels, but only GN6ST was consistently over-expressed. We suggest that very high level expression of GN6ST is a useful diagnostic marker for a subgroup of previously unclassified ALL.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Timson G,Banavali S,Gutierrez MI,Magrath I,Bhatia KG,Goyns MH

doi

10.1016/j.canlet.2005.11.012

keywords:

subject

Has Abstract

pub_date

2006-10-28 00:00:00

pages

239-44

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(05)00999-7

journal_volume

242

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Peroxiredoxin I expression in human thyroid tumors.

    abstract：:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00243-8

    authors： Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

    更新日期：1999-10-18 00:00:00

  • Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: a potential target for 'two-in-one' cancer chemoimmunotherapeutics.

    abstract：:An emerging trend in cancer chemoimmunotherapeutics is to develop 'two-in-one' therapies, which directly inhibit tumor growth and progression, as well as enhance anti-tumor immune surveillance. Protein kinase A (PKA) is a cAMP-dependent protein kinase that mediates signal transduction of G-protein coupled receptors (G...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.07.047

    authors： Hussain M,Tang F,Liu J,Zhang J,Javeed A

    更新日期：2015-12-01 00:00:00

  • Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.

    abstract：:5-FU is commonly used for treatment of various solid tumors including colon carcinoma. We have previously demonstrated that Egr-1 induced by 5-FU enhanced TSP-1 expression in human colon cancer KM12C cells. In this study, a Genechip analysis of KM12C cells treated with 5-FU revealed down-regulation of 924 genes and up...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.04.045

    authors： Zhao HY,Ooyama A,Yamamoto M,Ikeda R,Haraguchi M,Tabata S,Furukawa T,Che XF,Iwashita K,Oka T,Fukushima M,Nakagawa M,Ono M,Kuwano M,Akiyama S

    更新日期：2008-10-18 00:00:00

  • The anticarcinogenic and tumor growth inhibitory activities of lymphotoxin are associated with altered membrane glycoprotein synthesis.

    abstract：:Membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone, lymphotoxin, to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells. Syrian hamster lymphotoxin increased the synthesis of high molecular wei...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90096-4

    authors： Fuhrer JP,Evans CH

    更新日期：1983-07-01 00:00:00

  • Advances in image enhancement for sarcoma surgery.

    abstract：:The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2020.03.029

    authors： Baljer BC,Kolhe S,Chan CD,Nicoli F,Ghanbasha A,Brookes MJ,Gamie Z,Ghosh KM,Beckingsale TB,Saleh DB,Ragbir M,Gerrand CH,Jeys L,Knight JC,Petrides G,Rankin KS

    更新日期：2020-07-28 00:00:00

  • 2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.

    abstract：:2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine (NPEOC-DAC), decitabine with a modification of the N4 position of the azacitidine ring can be used to inhibit DNA methyltransferase. This modification protects the azacitidine ring and can be cleaved by carboxylesterase to release decitabine. NPEOC-DAC was 23...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.02.069

    authors： Byun HM,Choi SH,Laird PW,Trinh B,Siddiqui MA,Marquez VE,Yang AS

    更新日期：2008-08-08 00:00:00

  • BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice.

    abstract：:BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.046

    authors： Hardy B,Morgenstern S,Raiter A,Rodionov G,Fadaeev L,Niv Y

    更新日期：2005-11-18 00:00:00

  • Nutlin-3 inhibits epithelial-mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis.

    abstract：:Enormous efforts have been made to explore small molecules that interfere with the TGF-β signaling pathway, so as to inhibit EMT and the cancer metastasis, but few agents have been identified. In this study, we demonstrated that Nutlin-3 could abolish the down-regulation of E-cadherin induced by TGF-β1 in p53-deficien...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.08.039

    authors： Wu Y,Fu Y,Zheng L,Lin G,Ma J,Lou J,Zhu H,He Q,Yang B

    更新日期：2014-01-01 00:00:00

  • mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo.

    abstract：:VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In v...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.04.015

    authors： Fuereder T,Jaeger-Lansky A,Hoeflmayer D,Preusser M,Strommer S,Cejka D,Koehrer S,Crevenna R,Wacheck V

    更新日期：2010-10-28 00:00:00

  • Bovine milk-derived exosomes for drug delivery.

    abstract：:Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective produc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.10.020

    authors： Munagala R,Aqil F,Jeyabalan J,Gupta RC

    更新日期：2016-02-01 00:00:00

  • Alanine metabolism in rats bearing the Yoshida AH-130 ascites hepatoma.

    abstract：:Rats bearing the Yoshida AH-130 ascites hepatoma, a cachectic rat tumour, showed signs of important muscle wasting with reduced muscle weights. This phenomenon was associated with a decreased rate of in vivo alanine oxidation as measured by the production of 14CO2 from [U-14C]alanine intragastrically administered. It ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90212-7

    authors： García-Martínez C,López-Soriano FJ,Argilés JM

    更新日期：1994-12-09 00:00:00

  • Adenovirus-mediated transfer of tris-shRNAs induced apoptosis of nasopharyngeal carcinoma cell in vitro and in vivo.

    abstract：:RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.05.028

    authors： Han JB,Tao ZZ,Chen SM,Kong YG,Xiao BK

    更新日期：2011-10-28 00:00:00

  • Variable-region sequences for T-cell receptor-gamma and -delta chains of rabbit killer cell lines against Shope carcinoma cells.

    abstract：:A rabbit gamma delta killer T-cell line against Shope carcinoma cells was established from peripheral blood lymphocytes (PBL) of a human T-lymphotropic virus type I (HTLV-I)-infected rabbit bearing Shope papilloma and carcinoma. Southern hybridization analysis of this cell line with an HTLV-I probe showed that the cel...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)90155-8

    authors： Kim CJ,Isono T,Tomoyoshi T,Seto A

    更新日期：1995-02-10 00:00:00

  • Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality.

    abstract：:This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and u...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.09.033

    authors： Rollan Haro AM,Smyth A,Hughes P,Reid CN,McHale AP

    更新日期：2005-05-10 00:00:00

  • Gut microbiota: A new piece in understanding hepatocarcinogenesis.

    abstract：:The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2020.01.002

    authors： Zhou A,Tang L,Zeng S,Lei Y,Yang S,Tang B

    更新日期：2020-04-01 00:00:00

  • Prediction models for platinum-based chemotherapy response and toxicity in advanced NSCLC patients.

    abstract：:In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.04.029

    authors： Yin JY,Li X,Li XP,Xiao L,Zheng W,Chen J,Mao CX,Fang C,Cui JJ,Guo CX,Zhang W,Gao Y,Zhang CF,Chen ZH,Zhou H,Zhou HH,Liu ZQ

    更新日期：2016-07-10 00:00:00

  • Effect of human procathepsin D on proliferation of human cell lines.

    abstract：:We have used human procathepsin D isolated from supernatant of human breast cancer cell line ZR-75-1 to test its mitogenic activity for a broad spectrum of human-derived cell lines. These cell lines included: breast cancer cell lines ZR-75-1, MDA-MB-436, MBA-MD-483 and MDA-MB-231, B lymphoblastoid cell line Raji, the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90251-8

    authors： Vĕtvicka V,Vĕktvicková J,Fusek M

    更新日期：1994-05-16 00:00:00

  • Expression of xenoantigen transformed human cancer cells to be susceptible to antibody-mediated cell killing.

    abstract：:The carbohydrate epitope, alphaGal epitope, is known as a major xenoantigen. The epitope exists abundantly in non-primate mammals and has recently been found on C-type retroviruses. Humans and Old World monkeys have anti-alphaGal antibody, a natural antibody. The present study was performed to examine if the alphaGal ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00377-9

    authors： Yoshimura N,Sawada T,Furusawa M,Fuchinoue S

    更新日期：2001-03-26 00:00:00

  • Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer.

    abstract：:To understand the role of cyclooxygenase-2 (COX-2) in gastric cancer, we examined the abundance of COX-2, vascular endothelial growth factor-A (VEGF-A), and CD34 in 45 surgically resected human gastric cancers and paired normal gastric mucosa by immunohistochemical analysis. In addition, the message RNA (mRNA) express...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(03)00153-8

    authors： Yu HG,Li JY,Yang YN,Luo HS,Yu JP,Meier JJ,Schrader H,Bastian A,Schmidt WE,Schmitz F

    更新日期：2003-05-30 00:00:00

  • Tumor induction by activated JNK occurs through deregulation of cellular growth.

    abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.05.015

    authors： Rennefahrt U,Illert B,Greiner A,Rapp UR,Troppmair J

    更新日期：2004-11-08 00:00:00

  • HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK.

    abstract：:Nuclear factor-kappa B (NF-kappaB) activation by tumor necrosis factor-alpha (TNF-alpha) attenuates the TNF-alpha-induced apoptosis pathway. Thus, blockage of NF-kappaB activity may improve the anti-cancer activity of TNF-alpha. HA14-1 induces apoptosis in various human cancer cells, and the molecular mechanisms of th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.11.014

    authors： Moon DO,Kim MO,Kang SH,Choi YH,Park SY,Kim GY

    更新日期：2010-06-01 00:00:00

  • Phenotypic differentiation of human breast cancer cells by 1,3 cyclic propanediol phosphate.

    abstract：:Breast cancer cells in their virulent undifferentiated state are characterized by lack of functional estrogen receptors (ER) and/or progesterone receptors (PR) as well as relatively low levels of other normal differentiation markers such as milk proteins and lipid droplets. To date, no method for in situ elevation of ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(03)00146-0

    authors： Adan Y,Goldman Y,Haimovitz R,Mammon K,Eilon T,Tal S,Tene A,Karmel Y,Shinitzky M

    更新日期：2003-05-08 00:00:00

  • Differential effects of butylated hydroxyanisole on metabolism of aflatoxin B1 in vitro by liver and lung microsomes.

    abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90261-3

    authors： Allameh A,Saxena M,Raj HG

    更新日期：1988-05-01 00:00:00

  • Soluble and membrane-bound catechol-O-methyltransferase in normal and malignant mammary gland.

    abstract：:The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical staining showed that the COMT reaction in normal mammary tissue was restrict...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00197-4

    authors： Tenhunen J,Heikkilä P,Alanko A,Heinonen E,Akkila J,Ulmanen I

    更新日期：1999-09-20 00:00:00

  • Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro.

    abstract：:Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)04104-4

    authors： McCotter D,van den Berg HW,Boylan M,McKibben B

    更新日期：1996-02-06 00:00:00

  • The TGFβ-induced lncRNA TBILA promotes non-small cell lung cancer progression in vitro and in vivo via cis-regulating HGAL and activating S100A7/JAB1 signaling.

    abstract：:Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.06.013

    authors： Lu Z,Li Y,Che Y,Huang J,Sun S,Mao S,Lei Y,Li N,Sun N,He J

    更新日期：2018-09-28 00:00:00

  • Enhanced XPA mRNA levels in cisplatin-resistant human ovarian cancer are not associated with XPA mutations or gene amplification.

    abstract：:Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04428-x

    authors： States JC,Reed E

    更新日期：1996-11-29 00:00:00

  • In vivo formation of DNA-adducts in mouse skin DNA by tamoxifen.

    abstract：:Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of T...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03802-4

    authors： Cai Q,Wei H

    更新日期：1995-06-08 00:00:00

  • The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides.

    abstract：:Bombesin-like peptides (BLP) and their receptors are widely distributed throughout the intestine and are potential mitogens for gastrointestinal cancers. In this study we characterized the proliferation induced by BLP in the human adenocarcinoma cell line HT-29. The number of HT-29 cells, partially serum deprived (1% ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00642-5

    authors： Cassano G,Resta N,Gasparre G,Lippe C,Guanti G

    更新日期：2001-10-30 00:00:00

  • Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy.

    abstract：:Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00185-7

    authors： Cohen JD,Strock DJ,Teik JE,Katz TB,Marcel PD

    更新日期：1997-06-24 00:00:00