Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.

abstract：:Transendothelial migration (TEM) of tumor cells is a crucial step in metastasis formation. The prevailing paradigm is that the mechanism underlying TEM of tumor cells is similar to that of leukocytes involving adhesion molecules and chemokines. Fractalkine (CX3CL1) is a unique membrane-bound chemokine that functions a...

journal_title：Cancer letters

authors： Nevo I,Sagi-Assif O,Meshel T,Ben-Baruch A,Jöhrer K,Greil R,Trejo LE,Kharenko O,Feinmesser M,Yron I,Witz IP

更新日期：2009-01-08 00:00:00

abstract：:The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence...

journal_title：Cancer letters

authors： Jacobson MK,Barton RA,Yoder SS,Sigh S,Lyle RE

更新日期：1979-02-01 00:00:00

abstract：:Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...

journal_title：Cancer letters

authors： Chen X,Fu E,Lou H,Mao X,Yan B,Tong F,Sun J,Wei L

更新日期：2019-08-01 00:00:00

abstract：:Pancreatic cancer is currently one of the deadliest solid malignancies and pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade, diagnostics and surgical techniques for PDAC have been evolving steadily; however, clinical outcomes of patients with PDAC have shown litt...

journal_title：Cancer letters

authors： Xiang J,Liu L,Wang W,Xu H,Wu C,Xu J,Liu C,Long J,Ni Q,Yu X

更新日期：2015-04-10 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on ...

journal_title：Cancer letters

authors： Wu Y,Wang W,Yang AG,Zhang R

更新日期：2020-12-01 00:00:00

abstract：:The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...

journal_title：Cancer letters

authors： Prezioso JA,Epperly MW,Wang N,Bloomer WD

更新日期：1992-03-31 00:00:00

abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...

journal_title：Cancer letters

authors： O'Brian CA,Ward NE,Vogel VG

更新日期：1990-01-01 00:00:00

abstract：:Interferon-beta (IFN-β) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-β, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN-β-induced increase in endogenous PML contri...

journal_title：Cancer letters

authors： Okazaki T,Kageji T,Kuwayama K,Kitazato KT,Mure H,Hara K,Morigaki R,Mizobuchi Y,Matsuzaki K,Nagahiro S

更新日期：2012-10-28 00:00:00

abstract：:Hepatitis B virus (HBV) is a major etiologic agent of hepatocellular carcinoma (HCC). However, the molecular mechanism by which HBV infection contributes to HCC development is not fully understood. Here, we initially showed that HBV stimulates the production of cancer stem cells (CSCs)-related markers (CD133, CD117 an...

journal_title：Cancer letters

authors： Liu Z,Dai X,Wang T,Zhang C,Zhang W,Zhang W,Zhang Q,Wu K,Liu F,Liu Y,Wu J

更新日期：2017-08-01 00:00:00

abstract：:Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...

journal_title：Cancer letters

authors： Fukushima M,Kuzuya K,Ota K,Ikai K

更新日期：1981-12-01 00:00:00

abstract：:Chemotherapeutic multidrug resistance (MDR) is a significant challenge to overcome in clinic practice. Several mechanisms contribute to MDR, one of which is the augmented drug efflux induced by the upregulation of ABCB1 in cancer cells. Regorafenib, a multikinase inhibitor targeting the RAS/RAF/MEK/ERK pathway, was ap...

journal_title：Cancer letters

authors： Wang YJ,Zhang YK,Zhang GN,Al Rihani SB,Wei MN,Gupta P,Zhang XY,Shukla S,Ambudkar SV,Kaddoumi A,Shi Z,Chen ZS

更新日期：2017-06-28 00:00:00

abstract：:Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...

journal_title：Cancer letters

authors： Takenaga K,Honma Y,Hozumi M

更新日期：1981-06-01 00:00:00

abstract：:We used selective biochemical markers of effect to evaluate some non-genotoxic cocarcinogenic properties of methyl thiophanate (MTH) associated with cytochrome P450 (CYP) changes. Several CYP-dependent reactions were monitored in the liver, kidney and lung microsomes of male and female Sprague-Dawley rats treated (i.p...

journal_title：Cancer letters

authors： Paolini M,Pozzetti L,Perocco P,Mazzullo M,Cantelli-Forti G

更新日期：1999-01-29 00:00:00

abstract：:The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...

journal_title：Cancer letters

authors： Nagabhushan M,Line D,Polverini PJ,Solt DB

更新日期：1992-10-21 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) following androgen deprivation therapy remains a major obstacle advanced prostate cancer management. Aromatase catalyzes estrogen from androgens, yet the role of aromatase-generated endogenous estrogen in CRPC is poorly understood. In this study, we assessed the expression a...

journal_title：Cancer letters

authors： Liang Z,Cao J,Tian L,Shen Y,Yang X,Lin Q,Zhang R,Liu H,Du X,Shi J,Zhang J

更新日期：2019-12-28 00:00:00

abstract：:The effects of turmeric (T), curcumins (Cs), aqueous turmeric extract (ATE) and curcumin-free aqueous turmeric extract (CFATE) on the formation of [3H]benzo[a]pyrene ([3H]B(a)P)-derived DNA adducts was studied in vitro employing mouse liver S9. A dose-dependent decrease in binding of [3H]B(a)P metabolites to calf thym...

journal_title：Cancer letters

authors： Deshpande SS,Maru GB

更新日期：1995-09-04 00:00:00

abstract：:The effects of glucocorticoids and cholesterol on morphological transformation have been studied using hamster embryo cells. The cells were exposed sequentially to benzo[a]pyrene (BP) (3 days) and the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) (4 days) before scoring for morphologically transformed colo...

journal_title：Cancer letters

authors： Rivedal E

更新日期：1982-02-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine which exerts biological activities on various cell types including neoplastic cells. We have investigated the biological effect of IL-6 and the expression of IL-6 receptors (IL-6R) on human colorectal carcinoma cell lines. Isreco-1 was derived from the primary site of a c...

journal_title：Cancer letters

authors： Schneider MR,Hoeflich A,Fischer JR,Wolf E,Sordat B,Lahm H

更新日期：2000-04-03 00:00:00

abstract：:Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

journal_title：Cancer letters

authors： Lester DR,Cauchi MN

更新日期：1990-05-15 00:00:00

abstract：:The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

journal_title：Cancer letters

authors： Yan X,Chua MS,Sun H,So S

更新日期：2008-04-08 00:00:00

abstract：:(-)-Epigallocatechin gallate (EGCG), a major constituent of green tea, has been shown to exhibit anti-cancer activity. Sulindac is also well known as a cancer-preventive agent against colon cancer, but its usage is restricted because of its adverse effects, as exemplified by gastrointestinal bleeding. In the present s...

journal_title：Cancer letters

authors： Ohishi T,Kishimoto Y,Miura N,Shiota G,Kohri T,Hara Y,Hasegawa J,Isemura M

更新日期：2002-03-08 00:00:00

abstract：:Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...

journal_title：Cancer letters

authors： Baxt WG

更新日期：1994-03-15 00:00:00

abstract：:The significance of altered expression of MN blood group antigens was examined by studies on the expressions of Thomsen-Friedenreich antigen (T antigen) and Tn antigen in primary and metastatic lesions of 29 human uterine cervical cancers. These antigens were measured by the avidin-biotin-peroxidase (ABC) method with ...

journal_title：Cancer letters

authors： Hamada S,Furumoto H,Kamada M,Hirao T,Aono T

更新日期：1993-11-01 00:00:00

abstract：:A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, rel...

journal_title：Cancer letters

authors： Egan KM,Thompson PA,Titus-Ernstoff L,Moore JH,Ambrosone CB

更新日期：2003-09-10 00:00:00

abstract：:The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...

journal_title：Cancer letters

authors： Nicolet C,Guérin E,Neuville A,Kerckaert JP,Wicker N,Bergmann E,Brigand C,Kedinger M,Gaub MP,Guenot D

更新日期：2009-09-18 00:00:00

abstract：:Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG ind...

journal_title：Cancer letters

authors： Bernhaus A,Fritzer-Szekeres M,Grusch M,Saiko P,Krupitza G,Venkateswarlu S,Trimurtulu G,Jaeger W,Szekeres T

更新日期：2009-02-18 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...

journal_title：Cancer letters

authors： Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

更新日期：2007-09-08 00:00:00

abstract：:Starting with an extract derived from the bark of Mundulea sericea Willd. (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified ...

journal_title：Cancer letters

authors： Lee SK,Luyengi L,Gerhäuser C,Mar W,Lee K,Mehta RG,Kinghorn AD,Pezzuto JM

更新日期：1999-02-08 00:00:00

abstract：:Thyroid hormone receptor interactor 4 (TRIP4), a subunit of the tetrameric nuclear activating signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in the regulation of cervical cancer growth and radiation resistance is presently unknown. In this study, TRIP4 was found to be highly...

journal_title：Cancer letters

authors： Che Y,Li Y,Zheng F,Zou K,Li Z,Chen M,Hu S,Tian C,Yu W,Guo W,Luo M,Deng W,Zou L

更新日期：2019-06-28 00:00:00

abstract：:Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells....

journal_title：Cancer letters

authors： Novak-Hofer I,Cohrs S,Grünberg J,Friedli A,Schlatter MC,Pfeifer M,Altevogt P,Schubiger PA

更新日期：2008-03-18 00:00:00