Metabolic tumor burden: a new promising way to reach precise personalized therapy in PDAC.

abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

journal_title：Cancer letters

authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

更新日期：1984-04-01 00:00:00

abstract：:The modifying effects of nonylphenol and genistein on cancer induction were assessed in a multi-organ carcinogenesis model in male F344 rats initially treated with five different carcinogens. In experiment 1 rats received 250 or 25 ppm nonylphenol, or 250 or 25 ppm genistein in their diet for 28 weeks. The total incid...

journal_title：Cancer letters

authors： Seike N,Wanibuchi H,Morimura K,Wei M,Nishikawa T,Hirata K,Yoshikawa J,Fukushima S

更新日期：2003-03-20 00:00:00

abstract：:The effect of pretreatment of skin of Sencar mice with topically applied tannic acid, quercetin and green tea polyphenols (GTP) on the skin tumor initiating activity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-2) has been evaluated. The animals were pretreated with ...

journal_title：Cancer letters

authors： Khan WA,Wang ZY,Athar M,Bickers DR,Mukhtar H

更新日期：1988-09-01 00:00:00

abstract：:Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patien...

journal_title：Cancer letters

authors： Kerr SH,Kerr DJ

更新日期：2009-12-01 00:00:00

abstract：:An enzyme immunoassay (EIA) was developed in which nuclear extracts were bound to the wells of polystyrene microtiter plates. The presence of various antigens in the extracts could be detected using antiserum raised against HeLa cell nucleoli. Normal human cell extracts, coupled to Sepharose as a solid phase absorbent...

journal_title：Cancer letters

authors： Kelsey DE,Busch RK,Busch H

更新日期：1981-05-01 00:00:00

abstract：:Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlor...

journal_title：Cancer letters

authors： Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu H

更新日期：1994-08-15 00:00:00

abstract：:In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited...

journal_title：Cancer letters

authors： Takasaki M,Konoshima T,Etoh H,Pal Singh I,Tokuda H,Nishino H

更新日期：2000-07-03 00:00:00

abstract：:Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated w...

journal_title：Cancer letters

authors： Jian Y,Wang M,Zhang Y,Ou R,Zhu Z,Ou Y,Chen X,Liang X,Ding Y,Song L,Xu X,Liao W

更新日期：2018-08-01 00:00:00

abstract：:Prostate cancer urgently needs an efficient therapy. Here we demonstrated that cisplatin combined with gene therapy by transfecting the attenuated Salmonella that carry a plasmid containing p53 gene and MDM2 siRNA provided a super-synergistic effect on the inhibition of prostate cancer growth in vivo. This synergistic...

journal_title：Cancer letters

authors： Jiang T,Zhou C,Gu J,Liu Y,Zhao L,Li W,Wang G,Li Y,Cai L

更新日期：2013-08-28 00:00:00

abstract：:Breast cancer stem cells (BCSCs) initiate and sustain breast cancers, and several putative markers have been proposed to prospectively isolate BCSC from the non-cancer stem cell population. The candidate BCSC marker Sca-1 is a GPI-linked membrane protein expressed on activated lymphocytes, hematopoietic stem cells and...

journal_title：Cancer letters

authors： Matilainen H,Yu XW,Tang CW,Berridge MV,McConnell MJ

更新日期：2012-10-01 00:00:00

abstract：:The heat shock protein 40kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions ...

journal_title：Cancer letters

authors： Sterrenberg JN,Blatch GL,Edkins AL

更新日期：2011-12-22 00:00:00

abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

journal_title：Cancer letters

authors： Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

更新日期：2018-12-01 00:00:00

abstract：:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...

journal_title：Cancer letters

authors： Fang LQ,Zhang H,Ding XY,Li DQ,Hou XL,Qiao H,Bai J,Wang ZB

更新日期：2010-12-28 00:00:00

abstract：:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...

journal_title：Cancer letters

authors： Jackson KM,DeLeon M,Verret CR,Harris WB

更新日期：2002-04-25 00:00:00

abstract：:Dinitropyrenes are mutagenic environmental pollutants. Of these compounds, 1,6-dinitropyrene is a potent tumorigen while 1,3-dinitropyrene appears to be weakly or non-tumorigenic. Two-electron reduction of dinitropyrenes yields nitro-nitrosopyrenes, which have been shown previously to be the major aerobic metabolites ...

journal_title：Cancer letters

authors： Djuric Z

更新日期：1992-07-31 00:00:00

abstract：:Oesophageal squamous cell carcinoma (OSCC) is highly prevalent in developing countries but there has been little recent progress into efficacious yet affordable treatment strategies. Drug repurposing is one attractive approach for cancer therapy. Disulfiram (DSF), used to treat alcoholism, inhibits cancer growth and w...

journal_title：Cancer letters

authors： Jivan R,Peres J,Damelin LH,Wadee R,Veale RB,Prince S,Mavri-Damelin D

更新日期：2018-03-28 00:00:00

abstract：:Of the erythropoietin-producing human hepatocellular receptors (Ephs), EphB4 has recently emerged as a potential target in several cancers due to its roles in modified cell migration and invasion. As little is known about the roles of EphB4 in glioma, we sought to investigate its function in glioma by in vitro cell mi...

journal_title：Cancer letters

authors： Kawahara Y,Furuta T,Sabit H,Tamai S,Dong Y,Jiapaer S,Zhang J,Zhang G,Oishi M,Miyashita K,Hayashi Y,Nakada M

更新日期：2019-05-01 00:00:00

abstract：:The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 a...

journal_title：Cancer letters

authors： An MJ,Cheon JH,Kim SW,Kim ES,Kim TI,Kim WH

更新日期：2009-06-28 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...

journal_title：Cancer letters

authors： Duan B,Cui J,Sun S,Zheng J,Zhang Y,Ye B,Chen Y,Deng W,Du J,Zhu Y,Chen Y,Gu L

更新日期：2016-08-28 00:00:00

abstract：:Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...

journal_title：Cancer letters

authors： Balassiano K,Lima S,Jenab M,Overvad K,Tjonneland A,Boutron-Ruault MC,Clavel-Chapelon F,Canzian F,Kaaks R,Boeing H,Meidtner K,Trichopoulou A,Laglou P,Vineis P,Panico S,Palli D,Grioni S,Tumino R,Lund E,Bueno-de-Mesqui

更新日期：2011-12-01 00:00:00

abstract：:Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...

journal_title：Cancer letters

authors： Oh BK,Seong JK,Lee JE,Chae KJ,Roh KJ,Park C,Park YN

更新日期：2002-12-01 00:00:00

abstract：:Breast cancer cells in their virulent undifferentiated state are characterized by lack of functional estrogen receptors (ER) and/or progesterone receptors (PR) as well as relatively low levels of other normal differentiation markers such as milk proteins and lipid droplets. To date, no method for in situ elevation of ...

journal_title：Cancer letters

authors： Adan Y,Goldman Y,Haimovitz R,Mammon K,Eilon T,Tal S,Tene A,Karmel Y,Shinitzky M

更新日期：2003-05-08 00:00:00

abstract：:Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in...

journal_title：Cancer letters

authors： Mousa SA,Sudha T,Dyskin E,Dier U,Gallati C,Hanko C,Chittur SV,Rebbaa A

更新日期：2010-03-28 00:00:00

abstract：:Citral inhibits the formation of retinoic acid from retinol in mouse epidermis. Since skin-carcinogenesis is sensitive to retinoid status, and retinoic acid may be the active form of vitamin A in the epidermis, citral was tested for its ability to modulate tumor promotion in a two-stage skin-carcinogenesis study in ha...

journal_title：Cancer letters

authors： Connor MJ

更新日期：1991-01-01 00:00:00

abstract：:Disinfection of drinking water has been one of the greatest public health successes. Numerous halogenated disinfection by-products (DBPs) occur and chronic ingestion has been associated with an increased risk for colorectal cancer in human populations. Because the intestinal microbiota can bioactivate xenobiotics, stu...

journal_title：Cancer letters

authors： George SE,Wolf DC,Brooks LR,Bailey KC,Hooth MJ,Nelson GM

更新日期：2004-02-10 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD10...

journal_title：Cancer letters

authors： Zhang C,Qiao H,Guo W,Liu Y,Yang L,Liu Y,Jin B,Fu M,Wang G,Li W

更新日期：2019-07-28 00:00:00

abstract：:Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...

journal_title：Cancer letters

authors： Jung J,Jang K,Ju JM,Lee E,Lee JW,Kim HJ,Kim J,Lee SB,Ko BS,Son BH,Lee HJ,Gong G,Ahn SY,Choi JK,Singh SR,Chang S

更新日期：2018-08-01 00:00:00

abstract：:Zinc finger transcription factors are DNA-binding proteins that are known to determine the identity of cells by regulating cell-specific gene expression. In addition, mutations in some members of this family have been found to be associated with several neoplasias, including Wilms' tumor and leukemias. Because the mec...

journal_title：Cancer letters

authors： Mesa K,Gebelein B,Cook T,Urrutia R

更新日期：1996-06-05 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydro...

journal_title：Cancer letters

authors： Lawson TA,Gingell R,Nagel D,Hines LA,Ross A

更新日期：1981-01-01 00:00:00