Novel treatments for hepatocellular cancer.

abstract：:Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

journal_title：Cancer letters

authors： Devens BH,Lundak RL,Byus CV

更新日期：1984-01-01 00:00:00

abstract：:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...

journal_title：Cancer letters

authors： Jiang W,Fujii H,Matsumoto T,Ohtsuji N,Tsurumaru M,Hino O

更新日期：2007-04-08 00:00:00

abstract：:Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...

journal_title：Cancer letters

authors： Stadler J,Yeung KS,Furrer R,Marcon N,Himal HS,Bruce WR

更新日期：1988-01-01 00:00:00

abstract：:The molecular chaperone Hsp90 is not only of major current interest in fundamental biological research but also recognised as an exciting new target for the treatment of cancer and other diseases. In addition to playing an important role in response to proteotoxic heat shock and others stresses, Hsp90 is also critical...

journal_title：Cancer letters

authors： Workman P

更新日期：2004-04-08 00:00:00

abstract：:We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...

journal_title：Cancer letters

authors： Kokura S,Yoshida N,Ueda M,Imamoto E,Ishikawa T,Takagi T,Naito Y,Okanoue T,Yoshikawa T

更新日期：2003-11-10 00:00:00

abstract：:Antitumor effects of nine components of a herbal medicine, 'Sho-saiko-to', were investigated on human hepatoma cell lines (PLC/PRF/5, Hep-G2), human liver cells (Chang) and a human pancreatic cancer cell line (BxPC-3). The concentration of each component required for 50% inhibition of cell growth of PLC/PRF/5 cells wa...

journal_title：Cancer letters

authors： Motoo Y,Sawabu N

更新日期：1994-10-28 00:00:00

abstract：:We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcuta...

journal_title：Cancer letters

authors： Re RN,Cook JL,Giardina JF

更新日期：2004-06-08 00:00:00

abstract：:Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigallocatechin-3-gallate (EGCG) pro...

journal_title：Cancer letters

authors： Paschka AG,Butler R,Young CY

更新日期：1998-08-14 00:00:00

abstract：:Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IG...

journal_title：Cancer letters

authors： Yao X,Wang Y,Duan Y,Zhang Q,Li P,Jin R,Tao Y,Zhang W,Wang X,Jing C,Zhou X

更新日期：2018-09-28 00:00:00

abstract：:Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic ...

journal_title：Cancer letters

authors： Mazzoni SM,Fearon ER

更新日期：2014-12-01 00:00:00

abstract：:Cancer stem cells (CSCs) are involved in tumorigenesis and progression of prostate cancer (PCa). Conventional anticancer therapeutics failed to eradicate CSCs, which may eventually lead to the disease relapse and metastasis. Therefore, targeting prostate CSCs may be an ideal strategy to cure PCa. Genistein is a major ...

journal_title：Cancer letters

authors： Zhang L,Li L,Jiao M,Wu D,Wu K,Li X,Zhu G,Yang L,Wang X,Hsieh JT,He D

更新日期：2012-10-01 00:00:00

abstract：:Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI and membrane both bound reactive substances of limited aqueous stability, such as from [14C]N-methyl-N-nitrosourea ([14C]NMU), and aqueous stable dyes of molecula...

journal_title：Cancer letters

authors： Povey AC,Bartsch H,O'Neill IK

更新日期：1987-07-01 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory eff...

journal_title：Cancer letters

authors： Zhang HG,Mehta K,Cohen P,Guha C

更新日期：2008-11-28 00:00:00

abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...

journal_title：Cancer letters

authors： Fujita K,Matsuda E,Sekine K,Iigo M,Tsuda H

更新日期：2004-09-15 00:00:00

abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

journal_title：Cancer letters

authors： Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

更新日期：2002-09-08 00:00:00

abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

journal_title：Cancer letters

authors： Padler-Karavani V

更新日期：2014-09-28 00:00:00

abstract：:Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in ...

journal_title：Cancer letters

authors： Gouas D,Shi H,Hainaut P

更新日期：2009-12-01 00:00:00

abstract：:BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intr...

journal_title：Cancer letters

authors： Hardy B,Morgenstern S,Raiter A,Rodionov G,Fadaeev L,Niv Y

更新日期：2005-11-18 00:00:00

abstract：:Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...

journal_title：Cancer letters

authors： Banerji A,Fernandes A,Bane S,Ahire S

更新日期：1998-07-03 00:00:00

abstract：:The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...

journal_title：Cancer letters

authors： Adachi S,Natsume H,Yamauchi J,Matsushima-Nishiwaki R,Joe AK,Moriwaki H,Kozawa O

更新日期：2009-05-08 00:00:00

abstract：:Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accomp...

journal_title：Cancer letters

authors： Francisco R,Pérez-Perarnau A,Cortés C,Gil J,Tauler A,Ambrosio S

更新日期：2012-05-01 00:00:00

abstract：:Condensed roofing asphalt fumes, generated at 316 degrees C, were collected by cold trap condensation and fractionated by preparative high performance liquid chromatography. Chemical classes in each of the fractions (A-E) were identified by gas chromatography/mass spectroscopy. The fractions, various combinations of f...

journal_title：Cancer letters

authors： Sivak A,Niemeier R,Lynch D,Beltis K,Simon S,Salomon R,Latta R,Belinky B,Menzies K,Lunsford A,Cooper C,Ross A,Bruner R

更新日期：1997-07-15 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene alcohol isolated from Cedrus atlantica, against GBM cells in vitro and in...

journal_title：Cancer letters

authors： Chang KF,Huang XF,Chang JT,Huang YC,Weng JC,Tsai NM

更新日期：2020-12-28 00:00:00

abstract：:In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...

journal_title：Cancer letters

authors： Kobayashi K,Mutai M,Goto K,Inada K,Tsukamoto T,Nakanishi H,Tatematsu M

更新日期：1997-09-16 00:00:00

abstract：:Diol-epoxide derivatives of polycyclic aromatic hydrocarbons are the ultimate carcinogenic forms of these compounds encountered in vivo. Using a novel electro-fluorescence apparatus, we report that, like the (+/-)-anti-diol-epoxide of benzo[a]pyrene (BP), the similar diol-epoxides of benzo[a]anthracene (BA) and 3-meth...

journal_title：Cancer letters

authors： Ridler P,Jennings B

更新日期：1984-02-01 00:00:00

abstract：:Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...

journal_title：Cancer letters

authors： Richter-Reichhelm HB,Emura M,Schneider P,Mohr U

更新日期：1979-11-01 00:00:00

abstract：INTRODUCTION:Glioma initiating cells (GICs) play important roles in tumor initiation and progression. However, interactions between tumor cells and host cells of local tumor microenvironment are kept largely unknown. Besides GICs and their progeny cells, whether adjacent normal glial cells contribute to tumorigenesis d...

journal_title：Cancer letters

authors： Chen Y,Wang Z,Dai X,Fei X,Shen Y,Zhang M,Wang A,Li X,Wang Z,Huang Q,Dong J

更新日期：2015-09-01 00:00:00

abstract：:Chronic myeloproliferative disorders (CMPD) are clonal disorders of the hematopoietic stem cell. The myeloid lineage shows increased proliferation with effective maturation, while peripheral leukocytosis, thrombocytosis or elevated red blood cell mass are found. In Philadelphia negative CMPD recurrent cytogenetic abno...

journal_title：Cancer letters

authors： Panani AD

更新日期：2007-09-18 00:00:00

abstract：:Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistan...

journal_title：Cancer letters

authors： Bockstahler LE,Lytle CD,Lubiniecki AS,Cantwell JM,Galleshaw JA

更新日期：1982-11-01 00:00:00