Abstract:
:Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene alcohol isolated from Cedrus atlantica, against GBM cells in vitro and in vivo. Cedrol was found to potently inhibit cell growth and induce intracellular ROS generation and DNA damage response. In addition, Cedrol induced significant G0/G1 cell cycle arrest and cell apoptosis via the extrinsic (Fas/FasL/Caspase-8) and intrinsic (Bax/Bcl-2/Caspase-9) pathways. In addition, Cedrol had a synergistic effect with temozolomide (TMZ) and reduced drug resistance by blockage of the AKT/mTOR pathway. Cedrol suppressed tumor growth in both orthotopic and xenograft GBM animal models with low or no short-term acute toxicity or long-term accumulative toxicity. In a molecular docking study, Cedrol targeted the androgen receptor (AR), and reduced DHT-mediated AR nuclear translocation, downstream gene KLK3/TMPRSS2 expression and cell proliferation. Our study demonstrates that Cedrol may be a potential candidate for drug development for single or combination treatment with TMZ in GBM therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chang KF,Huang XF,Chang JT,Huang YC,Weng JC,Tsai NMdoi
10.1016/j.canlet.2020.09.007subject
Has Abstractpub_date
2020-12-28 00:00:00pages
180-190eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30469-9journal_volume
495pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90085-v
更新日期:1991-02-01 00:00:00
abstract::Vemurafenib, a BRAF inhibitor, elicits in ∼80% of BRAFV600E-mutant melanoma patients a transient anti-tumor response which precedes the emergence of resistance. We tested whether an acidic tumor microenvironment may favor a BRAF inhibitor resistance. A375M6 BRAFV600E melanoma cells, either exposed for a short period o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.08.010
更新日期:2017-11-01 00:00:00
abstract::The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90093-3
更新日期:1982-05-01 00:00:00
abstract::The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.11.014
更新日期:2009-05-08 00:00:00
abstract::Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00131-7
更新日期:1999-09-01 00:00:00
abstract::Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice. PANC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with EA. Th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.05.009
更新日期:2013-09-01 00:00:00
abstract::Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.03.019
更新日期:2011-08-01 00:00:00
abstract::Cancer stem cells (CSCs) are involved in tumorigenesis and progression of prostate cancer (PCa). Conventional anticancer therapeutics failed to eradicate CSCs, which may eventually lead to the disease relapse and metastasis. Therefore, targeting prostate CSCs may be an ideal strategy to cure PCa. Genistein is a major ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.03.037
更新日期:2012-10-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a r...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.01.021
更新日期:2014-05-01 00:00:00
abstract::Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.06.038
更新日期:2005-11-18 00:00:00
abstract::Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.06.013
更新日期:2018-09-28 00:00:00
abstract::The bmi-1 gene was identified as a common proviral integration site in Moloney murine leukemia virus. In the present studies, we cloned and sequenced the rat bmi-1 gene by reverse transcriptase-polymerase chain reaction (RT-PCR) using degenerate PCR primers of homologous sequences between mouse and human. We found 93%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00192-x
更新日期:1998-11-13 00:00:00
abstract::Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.06.020
更新日期:2008-11-28 00:00:00
abstract::The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.12.010
更新日期:2008-04-08 00:00:00
abstract::The aim of this study was to clarify candidate peptides for peptide-based specific immunotherapy of patients with oral squamous cell carcinoma (SCC). Thirteen peptides were examined for in vitro induction of peptide-specific CD8(+) T lymphocyte (CD8(+)TL) activity in peripheral blood mononuclear cells from 35 patients...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.02.016
更新日期:2012-09-01 00:00:00
abstract::Metabolic syndrome (MS) and related disorders, including cancer, are steadily increasing in most countries of the world. However, mechanisms underlying the link between MS and colon carcinogenesis have yet to be fully elucidated. In this review article we focus on the relationships between various individual associate...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.10.012
更新日期:2013-06-28 00:00:00
abstract::Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.012
更新日期:2016-12-01 00:00:00
abstract::We evaluated the influence of age and sex on rectal cell proliferation of 69 hospital controls and 66 patients with colorectal adenomas, by means of incubation of rectal biopsies with tritiated thymidine and autoradiography. In particular, we evaluated the labeling frequency in the upper 40% of rectal crypts (0 h), ac...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90203-a
更新日期:1990-09-01 00:00:00
abstract::Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.06.007
更新日期:2010-12-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.114426
更新日期:2019-09-28 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the changes in the number of HSF1 granules in the nucleus caused by different degree of heat stress. MATERIALS AND METHODS:A human esophageal cancer cell line, TE-2, was used. HSF1 granules were examined in an immunofluorescence study, and the changes in the average numb...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00481-6
更新日期:2003-12-08 00:00:00
abstract::In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04372-8
更新日期:1996-10-22 00:00:00
abstract::The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90049-6
更新日期:1983-09-01 00:00:00
abstract::The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(79)90007-7
更新日期:1979-12-01 00:00:00
abstract::The incidence of breast cancer has increased rapidly in recent years and has now become the most common cancer in women in major cities of China. Here, we reviewed the history and progress of breast cancer research in China, including achievements that Chinese scientists have made in basic, translational and clinical ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.04.007
更新日期:2014-08-28 00:00:00
abstract::We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.08.012
更新日期:2009-01-18 00:00:00
abstract::In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00222-x
更新日期:1997-09-16 00:00:00
abstract::Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.05.015
更新日期:2004-11-08 00:00:00
abstract::Oesophageal squamous cell carcinoma (OSCC) is highly prevalent in developing countries but there has been little recent progress into efficacious yet affordable treatment strategies. Drug repurposing is one attractive approach for cancer therapy. Disulfiram (DSF), used to treat alcoholism, inhibits cancer growth and w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.12.026
更新日期:2018-03-28 00:00:00
abstract::Sulfasalazine (SSZ) is an anti-inflammatory drug that has been demonstrated to induce apoptosis and tumor regression through inhibition of plasma membrane cystine transporter xc(-). Cysteine is a rate-limiting precursor for intracellular glutathione (GSH) synthesis, which is vital for compound detoxification and maint...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.07.031
更新日期:2015-11-01 00:00:00