Abstract:
:Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a role. We and others have been interested in elucidating molecular targets of NSAID-induced apoptosis. In this review, we summarize updated literature regarding cellular and molecular targets modulated by NSAIDs. Among those NSAIDs, sulindac sulfide and tolfenamic acid are emphasized in this review because these two drugs have been well investigated for their anti-tumorigenic activity in many different types of cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Liggett JL,Zhang X,Eling TE,Baek SJdoi
10.1016/j.canlet.2014.01.021subject
Has Abstractpub_date
2014-05-01 00:00:00pages
217-24issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00057-3journal_volume
346pub_type
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