Abstract:
:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the control group. Cyclophosphamide produced a greater inhibition of growth and resulted in a 96% reduction in DNA content relative to the control. DFMO in combination with cyclophosphamide provided no greater inhibition of tumor growth than that of cyclophosphamide as a single agent. Further, in the schedule used in this experimental protocol the toxicity to the host of the drug combination was additive.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Heston WD,Kadmon D,Fair WRdoi
10.1016/0304-3835(82)90093-3subject
Has Abstractpub_date
1982-05-01 00:00:00pages
71-79issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(82)90093-3journal_volume
16pub_type
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