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LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation.

Abstract：

:Oxidative phosphorylation (OXPHOS) in cancer has attracted a considerable attention in the past decades, and accumulated evidence has suggested that it plays an important role in tumor proliferation, metastasis and drug resistance. However, the mechanisms involved in these effects are still ambiguous to date. In this study, we found that LYR motif containing 2 (LYRM2), a novel molecule, is up-regulated in colorectal cancer and promotes tumor growth both in vivo and in vitro. Furthermore, we discovered that LYRM2 locates in the mitochondria, directly interacts with complex I and increases its activity, thus promoting OXPHOS in colorectal cancer cells. More importantly, we identified a new Akt-S58phos-LYRM2-Complex I axis, which is responsible for the LYRM2-induced tumor growth and the activation of OXPHOS in colorectal cancer. Our finding illustrates the role of LYRM2 in regulating tumor metabolism and provides a new potential target for colorectal cancer treatment.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Huang Q,Chen Z,Cheng P,Jiang Z,Wang Z,Huang Y,Yang C,Pan J,Qiu F,Huang J

doi

10.1016/j.canlet.2019.04.021

subject

Has Abstract

pub_date

2019-07-28 00:00:00

pages

36-47

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(19)30252-6

journal_volume

455

pub_type

杂志文章

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