Abstract：
:Chemical agents including 5-iodo-2'-deoxyuridine (IUdR), 4-O-methyl 12-O-tetradecanoyl phorbol-13-acetate (TPA), phorbol, and the tumor promoters teleocidin and TPA were tested for their ability to induce Human T-cell leukemia-lymphoma virus Type I (HTLV-I) expression in the low-virus producer MT-1 cell line and in the non-virus producer C63/CRII-2 cell line, which contains at least one integrated HTLV-I genome equivalent per cell [26]. Viral antigen expression increased from 0.3% to 8.7% in the MT-1 cell line after treatment with IUdR, while TPA and teleocidin were marginally or non-effective as inducers. Chemicals did not induce HTLV-I antigen expression in the C63/CI(II-2) cell line. No enhancement of reverse transcriptase activity or alteration of proviral organization was observed after chemical treatment of MT-1 cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Carter LJ,Blakeslee JR Jrdoi
10.1016/0304-3835(88)90077-8subject
Has Abstractpub_date
1988-04-01 00:00:00pages
329-38issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(88)90077-8journal_volume
39pub_type
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