Abstract:
:Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats received either a standard diet or a high fat diet (HFD), supplemented or not with Orlistat (200mg/kg chow) and two doses of the carcinogen dimethyl-hydrazine (25mg/Kg). After 30 days, Orlistat was associated to a significant increase in the number of colonic ACFs and cell proliferation in DMH-treated animals, independently of the HFD.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Garcia SB,Barros LT,Turatti A,Martinello F,Modiano P,Ribeiro-Silva A,Vespúcio MV,Uyemura SAdoi
10.1016/j.canlet.2005.09.011keywords:
subject
Has Abstractpub_date
2006-08-28 00:00:00pages
221-4issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00860-8journal_volume
240pub_type
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