Amine nitrosation by sodium nitroprusside.

abstract：:We generated three anti-ErbB-2 monoclonal antibodies (mAbs) by using surface-epitope masking method (SEM method). They were characterized and shown to recognize the extracellular domain (ECD) of ErbB-2 specifically. In order to detect ErbB-2 in the sera of breast cancer patients, we used two of them: A18 and A21 to de...

journal_title：Cancer letters

authors： Li P,Li Y,Li JY,Liu J

更新日期：2003-04-25 00:00:00

abstract：:The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...

journal_title：Cancer letters

authors： Nicolet C,Guérin E,Neuville A,Kerckaert JP,Wicker N,Bergmann E,Brigand C,Kedinger M,Gaub MP,Guenot D

更新日期：2009-09-18 00:00:00

abstract：:Natural products play a pivotal role in medicine especially in the cancer arena. Many drugs that are currently used in cancer chemotherapy originated from or were inspired by nature. Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Prel...

journal_title：Cancer letters

authors： Qazzaz ME,Raja VJ,Lim KH,Kam TS,Lee JB,Gershkovich P,Bradshaw TD

更新日期：2016-01-28 00:00:00

abstract：:Iron-oxide nanoparticles of small dimensions that have superparamagnetic properties show immense potential to revolutionize the future of cancer theranostics, the combinatorial diagnosis and therapeutic approach towards cancer. Superparamagnetic iron-oxide nanoparticles (SPIONs) have unique magnetic properties, due to...

journal_title：Cancer letters

authors： Santhosh PB,Ulrih NP

更新日期：2013-08-09 00:00:00

abstract：:Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

journal_title：Cancer letters

authors： Dipple A,Schultz E

更新日期：1979-07-01 00:00:00

abstract：:The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently...

journal_title：Cancer letters

authors： Zhang Y,Huang S,Dong W,Li L,Feng Y,Pan L,Han Z,Wang X,Ren G,Su D,Huang B,Lu J

更新日期：2009-05-08 00:00:00

abstract：:The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

journal_title：Cancer letters

authors： Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

更新日期：2001-07-10 00:00:00

abstract：:The malignant phenotype results from multiple genetic alterations, including the activation of oncogenes and inactivation of tumor suppressor genes. Activation of the Ki-ras oncogene has been implicated as an early event in the pathogenesis of lung adenocarcinomas in humans and experimental animal models. Previous stu...

journal_title：Cancer letters

authors： Mizesko MC,Grewe C,Grabner A,Miller MS

更新日期：2001-10-22 00:00:00

abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...

journal_title：Cancer letters

authors： Bellec G,Goasduff T,Dreano Y,Menez JF,Berthou F

更新日期：1996-02-27 00:00:00

abstract：:Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant found in plants, such as grapes, that studies suggest has cancer chemopreventive activity. We investigated the effects of resveratrol on DNA binding via esterification reactions with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP...

journal_title：Cancer letters

authors： Dubuisson JG,Dyess DL,Gaubatz JW

更新日期：2002-08-08 00:00:00

abstract：:(-)-Epigallocatechin gallate (EGCG), a major constituent of green tea, has been shown to exhibit anti-cancer activity. Sulindac is also well known as a cancer-preventive agent against colon cancer, but its usage is restricted because of its adverse effects, as exemplified by gastrointestinal bleeding. In the present s...

journal_title：Cancer letters

authors： Ohishi T,Kishimoto Y,Miura N,Shiota G,Kohri T,Hara Y,Hasegawa J,Isemura M

更新日期：2002-03-08 00:00:00

abstract：:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...

journal_title：Cancer letters

authors： Martens U,Lennartsson P,Högberg J,Stenius U

更新日期：1996-06-24 00:00:00

abstract：:Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

journal_title：Cancer letters

authors： Devens BH,Lundak RL,Byus CV

更新日期：1984-01-01 00:00:00

abstract：:The cancer chemotherapeutic drug, 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC, DTIC, NSC-45388), is metabolised in rats to a structurally related product which was detected by thin-layer chromatography. The novel metabolite has a lower mobility and a colour reaction that is indistinguishable from the pare...

journal_title：Cancer letters

authors： Kolar GF,Maurer M,Wildschütte M

更新日期：1980-09-01 00:00:00

abstract：:Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). In our system ornithine decarboxylase (ODC) activity correlates well with growth rate; it was investigated whether the antiproliferative effects of IFN-gamma and IF...

journal_title：Cancer letters

authors： Marth C,Kirchebner P,Daxenbichler G

更新日期：1989-01-01 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), an established enzyme-biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSM...

journal_title：Cancer letters

authors： Liu T,Wu LY,Berkman CE

更新日期：2010-10-01 00:00:00

abstract：:Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...

journal_title：Cancer letters

authors： Yit CC,Das NP

更新日期：1994-07-15 00:00:00

abstract：:We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...

journal_title：Cancer letters

authors： Nadkarni NJ,Geest KD,Neff T,Young BD,Bender DP,Ahmed A,Smith BJ,Button A,Goodheart MJ

更新日期：2013-04-30 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant form of central nervous system tumor, and current therapies are largely ineffective at treating the cancer. Developing a more complete understanding of the mechanisms controlling the tumor is important in order to explore new possible treatment options. It is specula...

journal_title：Cancer letters

authors： Haley EM,Kim Y

更新日期：2014-04-28 00:00:00

abstract：:For biochemical modulation, components of green tea have been shown to be useful modulators in combination with doxorubicin (DOX). We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells. Because theanine is a glutamate analogue, we found that it is assoc...

journal_title：Cancer letters

authors： Sadzuka Y,Yamashita Y,Sugiyama T,Sonobe T

更新日期：2002-05-28 00:00:00

abstract：:Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...

journal_title：Cancer letters

authors： Lundberg I,Högberg J,Kronevi T,Holmberg B

更新日期：1987-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are an homologous family of proteolytic enzymes capable of degrading components of the extracellular matrix (ECM) and thereby facilitating the invasion of tumour cells into normal tissues. The neural cell adhesion molecules (NCAMs) of neuronal and glial cells provide a Ca2+-independent...

journal_title：Cancer letters

authors： Maidment SL,Rucklidge GJ,Rooprai HK,Pilkington GJ

更新日期：1997-06-03 00:00:00

abstract：AIM:To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS:830 women with prior hysterectomy for benign/malign...

journal_title：Cancer letters

authors： Frega A,French D,Piazze J,Cerekja A,Vetrano G,Moscarini M

更新日期：2007-05-08 00:00:00

abstract：:In previous studies, we confirmed that mitofusin-2 (Mfn2) induced apoptosis in hepatocellular carcinoma (HCC) cells. However, the exact molecular mechanism remained unclear. Mfn2 expressed lower in tumour tissues, compared with adjacent non-cancer tissues. Furthermore, Mfn2 immunostaining was very weak in HCC tissue (...

journal_title：Cancer letters

authors： Wang W,Xie Q,Zhou X,Yao J,Zhu X,Huang P,Zhang L,Wei J,Xie H,Zhou L,Zheng S

更新日期：2015-03-01 00:00:00

abstract：:Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...

journal_title：Cancer letters

authors： Beerepoot LV,Mehra N,Linschoten F,Jorna AS,Lisman T,Verheul HM,Voest EE

更新日期：2004-09-30 00:00:00

abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

journal_title：Cancer letters

authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

更新日期：2006-07-08 00:00:00

abstract：:Suicide gene therapy could be an attractive addition to the treatment of ovarian carcinomas, for which acquired chemoresistance frequently results in treatment failure. Here we show that transfection of the HSV-tk gene, followed by incubation with up to 1 mM ganciclovir fails to induce cell death in SKOV3 chemoresista...

journal_title：Cancer letters

authors： Ziller C,Lincet H,Muller CD,Staedel C,Behr JP,Poulain L

更新日期：2004-08-20 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00

abstract：:Twenty-eight transparent chambers were inserted into the cheek pouches of hamsters and daily serial observations made of the changing vasculature of transplants of 2 varieties (A-Mel-4B32, ZGYP1) of amelanotic melanomas. The tumor A-Mel-4B32 grew at a rate which covered 50% of the viewing area in 3--4 days, while the ...

journal_title：Cancer letters

authors： Warren BA,Shubik P,Wilson R,Garcia H,Feldman R

更新日期：1978-02-01 00:00:00