当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > A novel integrated system using patient-derived glioma cerebral organoids and xenografts for disease modeling and drug screening.

A novel integrated system using patient-derived glioma cerebral organoids and xenografts for disease modeling and drug screening.

Abstract：

:A physiologically relevant glioma tumor model is important to the study of disease progression and screening drug candidates. However, current preclinical glioma models lack the brain microenvironment, and the established tumor cell lines do not represent glioma biology and cannot be used to evaluate the therapeutic effect. Here, we reported a real-time integrated system by generating 3D ex vivo cerebral organoids and in vivo xenograft tumors based on glioma patient-derived tissues and cells. Our system faithfully recapitulated the histological features, response to chemotherapy drugs, and clinical progression of their corresponding parental tumors. Additionally, our model successfully identified a case from a grade II astrocytoma patient with typical grade IV GBM features in both organoids and xenograft models, which mimicked the disease progression of this patient. Further genomic and transcriptomic characterization was associated with individual clinical features. We have demonstrated the "GBM-&Normal-like" signature to predict prognosis. In conclusion, we developed an integrated system of parallel models from patient-derived glioma cerebral organoids and xenografts for understanding the glioma biology and prediction of response to chemotherapy drugs, which might lead to a new strategy for personalized treatment for this deadly disease.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zhang L,Liu F,Weygant N,Zhang J,Hu P,Qin Z,Yang J,Cheng Q,Fan F,Zeng Y,Tang Y,Li Y,Tang A,He F,Peng J,Liao W,Hu Z,Li M,Liu Z

doi

10.1016/j.canlet.2020.12.013

subject

Has Abstract

pub_date

2021-03-01 00:00:00

pages

87-97

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(20)30663-7

journal_volume

500

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice.

    abstract：:The pulmonary tumorigenicity of dimethylarsinic acid (DMAA), a main metabolite of inorganic arsenics, was examined in A/J mice fed with drinking water containing DMAA for 25 and 50 weeks. Mice fed with 400 ppm DMAA for 50 weeks produced more pulmonary tumors than untreated mice (mean number per animal 1.36 versus 0.50...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00484-9

    authors： Hayashi H,Kanisawa M,Yamanaka K,Ito T,Udaka N,Ohji H,Okudela K,Okada S,Kitamura H

    更新日期：1998-03-13 00:00:00

  • Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer.

    abstract：:Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.12.027

    authors： Awasthi N,Hinz S,Brekken RA,Schwarz MA,Schwarz RE

    更新日期：2015-03-01 00:00:00

  • Mechanism of uptake of sulfonated metallophthalocyanines by cultured mammalian cells.

    abstract：:The uptake of several metallophthalocyanine tetrasulfonates by cultured Chinese hamster cells was studied. Uranyl- and chloraluminium were taken up at the highest rate followed by Ni-, Zn-, Cu-, Co- and dichlorosilicon-phthalocyanine tetrasulfonate. The uptake from the growth medium containing 10% serum in which only ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90217-5

    authors： Ben-Hur E,Siwecki JA,Newman HC,Crane SW,Rosenthal I

    更新日期：1987-12-01 00:00:00

  • Mechanisms of immune evasion of human neuroblastoma.

    abstract：:Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2004.11.064

    authors： Raffaghello L,Prigione I,Airoldi I,Camoriano M,Morandi F,Bocca P,Gambini C,Ferrone S,Pistoia V

    更新日期：2005-10-18 00:00:00

  • Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.

    abstract：:Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90134-4

    authors： Lockshin A,Giovanella BC,Kozielski T,Stehlin JS Jr

    更新日期：1984-09-01 00:00:00

  • The field bean protease inhibitor has the potential to suppress B16F10 melanoma cell lung metastasis in mice.

    abstract：:Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00090-1

    authors： Banerji A,Fernandes A,Bane S,Ahire S

    更新日期：1998-07-03 00:00:00

  • Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel.

    abstract：:Previous studies point to protein kinase C (PKC) isozyme eta as a resistance factor in cancer cells. Therefore, we investigated whether down-regulation of PKCeta with second generation antisense oligonucleotides (ODNs) would sensitise A549 human lung carcinoma cells to cytostatics. The effects were compared to the out...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.02.001

    authors： Sonnemann J,Gekeler V,Ahlbrecht K,Brischwein K,Liu C,Bader P,Müller C,Niethammer D,Beck JF

    更新日期：2004-06-25 00:00:00

  • Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.

    abstract：:The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.10.013

    authors： Xu B,Guo X,Mathew S,Armesilla AL,Cassidy J,Darling JL,Wang W

    更新日期：2010-05-28 00:00:00

  • Post-transplant lymphoproliferative disorders: from epidemiology to pathogenesis-driven treatment.

    abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.08.007

    authors： Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

    更新日期：2015-12-01 00:00:00

  • MARCKS inhibition cooperates with autophagy antagonists to potentiate the effect of standard therapy against drug-resistant multiple myeloma.

    abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.03.020

    authors： Zhang L,Rastgoo N,Wu J,Zhang M,Pourabdollah M,Zacksenhaus E,Chen Y,Chang H

    更新日期：2020-06-28 00:00:00

  • Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells.

    abstract：:Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.03.018

    authors： Janouskova H,Ray AM,Noulet F,Lelong-Rebel I,Choulier L,Schaffner F,Lehmann M,Martin S,Teisinger J,Dontenwill M

    更新日期：2013-08-19 00:00:00

  • The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.

    abstract：:To clarify the roles of Bmi-1 in colorectal carcinoma, we examined the expression of Bmi-1 in 41 samples out of 46 colorectal carcinomas by reverse transcription-PCR, whereas all 46 were analyzed by immunostaining. In addition, we analyzed the expression patterns of Bmi-1 in association with p16INK4a and p14ARF (in mo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.07.009

    authors： Kim JH,Yoon SY,Kim CN,Joo JH,Moon SK,Choe IS,Choe YK,Kim JW

    更新日期：2004-01-20 00:00:00

  • Coclastogenicity of ethanol with cigarette smoke in rat erythroblasts and anticlastogenicity in alveolar macrophages.

    abstract：:A series of experiments was carried out to assess cytotoxic and cytogenetic effects in bone marrow polychromatic erythrocytes (PCE) and pulmonary alveolar macrophages (PAM) resulting from individual or combined exposure of male BD6 rats to ethanol, cigarette smoke and Aroclor 1254. Addition of 5% ethanol to drinking w...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90127-u

    authors： Balansky RM,Blagoeva PM,Mircheva ZI,de Flora S

    更新日期：1993-08-31 00:00:00

  • Anti-angiogenic activity of ursodeoxycholic acid and its derivatives.

    abstract：:Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per C...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)04604-1

    authors： Suh H,Jung EJ,Kim TH,Lee HY,Park YH,Kim KW

    更新日期：1997-02-26 00:00:00

  • Artesunate reduces chicken chorioallantoic membrane neovascularisation and exhibits antiangiogenic and apoptotic activity on human microvascular dermal endothelial cell.

    abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.03.014

    authors： Huan-huan C,Li-Li Y,Shang-Bin L

    更新日期：2004-08-10 00:00:00

  • Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens.

    abstract：:Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site o...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90069-8

    authors： Rice JM,Anderson LM

    更新日期：1986-12-01 00:00:00

  • NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling.

    abstract：:As a third-generation platinum drug, oxaliplatin has been widely applied in colorectal cancer (CRC); however, acquired resistance to oxaliplatin has become a major obstacle. In the present study, we found that the nuclear transcription factor Y subunit beta (NFYB) and E2F transcription factor 1 (E2F1) expression level...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.11.040

    authors： Fang Z,Gong C,Yu S,Zhou W,Hassan W,Li H,Wang X,Hu Y,Gu K,Chen X,Hong B,Bao Y,Chen X,Zhang X,Liu H

    更新日期：2018-02-28 00:00:00

  • Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma.

    abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.09.014

    authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

    更新日期：2012-01-01 00:00:00

  • The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs.

    abstract：:Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.07.028

    authors： Tang S,Yang L,Tang X,Liu M

    更新日期：2014-10-28 00:00:00

  • MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses.

    abstract：:The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.05.034

    authors： Zhao Q,Yu X,Li M,Liu Y,Han Y,Zhang X,Li XM,Wu X,Qin J,Fang J,Zhang H

    更新日期：2019-09-10 00:00:00

  • Effect of probenecid and N'-methylnicotinamide on renal handling of cis-dichlorodiammineplatinum-II in rats.

    abstract：:The renal handling of cisplatin was investigated in Sprague-Dawley rats in the presence and absence of probenecid and N'-methylnicotinamide. The renal clearance of free cisplatin was not significantly different from the glomerular filtration rate. N'-Methylnicotinamide, an organic cation, did not affect cisplatin clea...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90143-x

    authors： Osman NM,Litterst CL

    更新日期：1983-05-01 00:00:00

  • Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation.

    abstract：:In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00498-0

    authors： Gratchev A,Siedow A,Bumke-Vogt C,Hummel M,Foss HD,Hanski ML,Kobalz U,Mann B,Lammert H,Mansmann U,Stein H,Riecken EO,Hanski C

    更新日期：2001-07-10 00:00:00

  • p53 protein expression in patients with hepatocellular carcinoma from the high incidence area of Guangxi, Southern China.

    abstract：:Mutation of the p53 gene has been reported in hepatocellular carcinoma (HCC) occurring worldwide. The most frequent p53 mutation has been found in HCCs in regions with high hepatitis B virus (HBV) infection and intake of aflatoxin B1 (AFB1). The aim of our study was to examine p53 protein expression in HCCs from a hig...

    journal_title：Cancer letters

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0304-3835(97)00352-2

    authors： Qin G,Su J,Ning Y,Duan X,Luo D,Lotlikar PD

    更新日期：1997-12-23 00:00:00

  • Restoration of IRF1-dependent anticancer effects by MEK inhibition in human cancer cells.

    abstract：:Interferon regulatory factor (IRF1) is a potent antiviral, antitumor and immune regulatory protein. Recently, we found that activated Ras/MEK inhibits antiviral response by downregulating IRF1 expression and renders cancer cells susceptible to oncolytic viruses. In this study, we sought to determine whether IRF1 downr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.12.017

    authors： AbuSara N,Razavi S,Derwish L,Komatsu Y,Licursi M,Hirasawa K

    更新日期：2015-02-28 00:00:00

  • Modulation of benzo[a]pyrene-induced morphological transformation of Syrian hamster embryo cells by butylated hydroxytoluene and butylated hydroxyanisole.

    abstract：:The Syrian hamster embryo cell transformation assay has been used to investigate the effect of two synthetic antioxidants on morphological transformation induced by the initiator benzo[a]pyrene (BP). A two-stage protocol was employed with an initiation phase of 2 days and a subsequent promotion phase of 5 days. When 1...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90024-8

    authors： Potenberg J,Schiffmann D,Kahl R,Hildebrandt AG,Henschler D

    更新日期：1986-11-01 00:00:00

  • p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations.

    abstract：:Alteration of the p16 tumor suppressor gene has been implicated as a critical lesion in the molecular pathogenesis of esophageal adenocarcinoma. The aim of this study was to characterize the spectrum of p16 alterations in surgically resected esophageal tissues, comprising histologically normal esophageal squamous and ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.06.025

    authors： Hardie LJ,Darnton SJ,Wallis YL,Chauhan A,Hainaut P,Wild CP,Casson AG

    更新日期：2005-01-20 00:00:00

  • Alterations in repair of alkylating agent-induced DNA damage in polyamine-depleted human cells.

    abstract：:Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90015-2

    authors： Snyder RD,Bhatt S

    更新日期：1993-08-16 00:00:00

  • The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy.

    abstract：:Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.02.057

    authors： Gouas D,Shi H,Hainaut P

    更新日期：2009-12-01 00:00:00

  • An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer.

    abstract：:Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.06.017

    authors： Premasekharan G,Gilbert E,Okimoto RA,Hamirani A,Lindquist KJ,Ngo VT,Roy R,Hough J,Edwards M,Paz R,Foye A,Sood R,Copren KA,Gubens M,Small EJ,Bivona TG,Collisson EA,Friedlander TW,Paris PL

    更新日期：2016-09-28 00:00:00

  • Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.

    abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.04.017

    authors： Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

    更新日期：2009-11-01 00:00:00