Abstract:
:Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in a context of HBV chronic infection. Here, we summarize the mechanisms of R249S formation and the possible role of p.R249S protein in HCC pathogenesis. Next, we discuss the significance of R249S as a biomarker to study the natural history of HCC and as a target for therapeutic approaches aimed at restoring wild-type p53 activity.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Gouas D,Shi H,Hainaut Pdoi
10.1016/j.canlet.2009.02.057subject
Has Abstractpub_date
2009-12-01 00:00:00pages
29-37issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00169-4journal_volume
286pub_type
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