Abstract：
:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in the neoplastic cells were twice the normal colon level. The concentrations of these two cyclic nucleotides were relatively constant throughout the normal colon. Thus, the anomalous tumor cyclic nucleotide concentrations are attributed to the specific cell population of the lesion and not to the site of development within the colon.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJdoi
10.1016/s0304-3835(78)93192-0subject
Has Abstractpub_date
1978-01-01 00:00:00pages
27-33issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(78)93192-0journal_volume
4pub_type
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