Abstract：
:The B16 malignant melanoma and its F1 variant line were described and compared in syngeneic C57BL/6 mice at short and long term periods after transplantation. No observable differences in gross or histological features were noted. In both lines, liver and lung metastasis was confirmed and kidney colonization proposed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wosko TJ,Ferrara DT,Sartori LSdoi
10.1016/0304-3835(84)90080-6subject
Has Abstractpub_date
1984-08-01 00:00:00pages
57-63issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(84)90080-6journal_volume
24pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.05.027
更新日期：2016-08-28 00:00:00
abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90183-v
更新日期：1992-02-29 00:00:00
abstract：:Sonodynamic therapy (SDT) is a form of ultrasound therapy that has been shown to preferentially damage malignant cells based on the relatively enlarged size and altered cytology of neoplastic cells in comparison to normal cells. This study sought to determine whether cytoskeletal-directed agents that either disrupt (c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.02.001
更新日期：2015-05-01 00:00:00
abstract：:The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor spheroids. In neuroblastoma spheroids, the combination of cisplatin and gemcitabine induced a complete cytostasis at clinical relevant concentrations. A synergistic effect ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.12.016
更新日期：2012-06-01 00:00:00
abstract：:Cancer stem cells (CSCs), which comprise a small proportion of total cancer cells, have special capacities for self-renewal, differentiation and tumor formation. Currently, CSCs are regarded as the major cause of the failure in anticancer therapy, such as chemoresistance and/or radioresistance, tumor recurrence and me...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2017.02.012
更新日期：2017-05-01 00:00:00
abstract：:In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.01.014
更新日期：2005-11-08 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.114428
更新日期：2019-09-28 00:00:00
abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90085-v
更新日期：1991-02-01 00:00:00
abstract：:Fas/APO-1/CD95, a member of the tumor necrosis factor (TNF) receptor superfamily, is a potential anti-cancer factor as it can induce apoptosis in tumor cells. However, despite the fact that many cancer cells express Fas on the membrane, some tumors such as prostate cancer display resistance to Fas-induced apoptosis. I...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.06.006
更新日期：2010-12-01 00:00:00
abstract：:To improve the knowledge of the underlying mechanisms of action involved in air pollution Particulate Matter (PM)-induced toxicity in human lungs, with a particular interest of the crucial role played by coated-organic chemicals, we were interested in the metabolic activation of Polycyclic Aromatic Hydrocarbons (PAH)-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.04.044
更新日期：2008-10-18 00:00:00
abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.10.018
更新日期：2008-02-18 00:00:00
abstract：OBJECTIVE:The bad prognosis of primary carcinoma of the Fallopian tube is ascribed to early lymphogenous metastasis. Due to the rarity of cases, there exist only few and divergent results on the importance of lymph node metastasis in the relevant literature. Thus, our study aimed at detecting the incidence of lymph nod...
journal_title：Cancer letters
pub_type： 杂志文章,多中心研究
doi：10.1016/s0304-3835(99)00273-6
更新日期：1999-12-01 00:00:00
abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.014
更新日期：2014-08-28 00:00:00
abstract：:The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00418-8
更新日期：2000-04-03 00:00:00
abstract：:Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.01.018
更新日期：2004-07-16 00:00:00
abstract：:The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00417-8
更新日期：2003-11-10 00:00:00
abstract：:Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.01.005
更新日期：2020-04-01 00:00:00
abstract：:Epidermal growth factor receptors (EGFR) expression is frequently amplified in human glioblastoma cells. Nimotuzumab, a monoclonal antibody (mAb) against EGFR, has been used globally in clinics as an anti-cancer agent. It is largely unknown whether the blockade of miR-21, a microRNA that is upregulated in glioma cells...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.08.043
更新日期：2014-01-01 00:00:00
abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00101-5
更新日期：2002-09-08 00:00:00
abstract：:To address the possible involvement of hyperinsulinemia in breast cancer development, we have examined the susceptibility of lean and obese Zucker rats to N-methyl-N-nitrosourea (MNU)-induced mammary cancer. Fifty-day-old female lean or obese Zucker rats received intraperitoneal (i.p.) injections of 37.5 or 20 mg/kg M...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00635-2
更新日期：2001-01-26 00:00:00
abstract：:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.02.063
更新日期：2008-08-08 00:00:00
abstract：:Lectins are suitable tools for investigating the glycoconjugate characteristics of metastatic cells. In the present study, we investigated whether there were differences between high metastatic T3 cells and a low metastatic isolate in their reactivities to several lectins specific for galactosyl and sialyl groups. Ana...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90177-j
更新日期：1991-08-01 00:00:00
abstract：:p27kip, as a cyclin dependent kinase inhibitor (CDKI), plays a pivotal role in the regulation of cell cycle progression and hepatocarcinogenesis. Herein, we revealed that p27 exhibited apparent nucleolar distribution and interacted with nucleolar protein nucleostemin (NS) in Hepatocellular carcinoma (HCC) cells. Furth...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.12.008
更新日期：2017-03-01 00:00:00
abstract：:Lung cancer is a heterogeneous disease that is impacted by environmental exposures and by constitutional genetic or epigenetic susceptibilities to disease development and progression. The United States and China have distinct and diverse populations and geographic environmental exposures that contribute to unique patt...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.10.009
更新日期：2020-01-01 00:00:00
abstract：:Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.08.002
更新日期：2020-10-28 00:00:00
abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.019
更新日期：2013-05-28 00:00:00
abstract：:Recent efforts have revealed that numerous natural antisense lncRNAs play a crucial role in the regulation of cancer biology. Here, based on our previous study, we further identified that the lncRNA FOXC2-AS1 and its antisense transcript FOXC2 are positively up-regulated in doxorubicin-resistant osteosarcoma cell line...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.03.018
更新日期：2017-06-28 00:00:00
abstract：:Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.06.029
更新日期：2011-11-28 00:00:00
abstract：:Acquired resistance to mechanisms of programmed cell death is one of the hallmarks of cancer. Human melanoma, in advanced stage, is hardly curable, due to development of several strategies that impair apoptosis induced by the death receptor and the mitochondrial pathways of apoptosis. Among these apoptosis escape stra...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.06.034
更新日期：2006-07-18 00:00:00
abstract：:Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.07.009
更新日期：2016-10-01 00:00:00
