Abstract:
:Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to soluble TRAIL and proteasome inhibitors alone, but responded well to their combined treatment. In co-culture with NSCs-mTRAIL, glioma cells appeared to be more prone to apoptosis than to treatment with soluble TRAIL, which was enhanced by proteasome inhibitor bortezomib. In vivo, the survival of animals bearing intracranial glial xenografts was significantly improved by NSCs-mTRAIL. The addition of bortezomib further enhanced the efficacy of NSCs-TRAIL treated group in one of examined tumor models. These data demonstrate that therapy with NSCs-mTRAIL is a potent cell based approach for treatment of glioma. Such an approach warrants further search for therapeutics capable of increasing sensitivity of glioma cells to mTRAIL in vivo.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Balyasnikova IV,Ferguson SD,Han Y,Liu F,Lesniak MSdoi
10.1016/j.canlet.2011.06.029subject
Has Abstractpub_date
2011-11-28 00:00:00pages
148-59issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00386-7journal_volume
310pub_type
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