Abstract:
:Previous studies had established that transforming growth factor-beta1 (TGF-beta1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial transitional cell carcinoma (TCC). In consistent with previously reported findings, the plasma TGF-beta1 concentration is also elevated in patients with superficial TCC. In vitro, the cytotoxic function of NK cells was impaired by the presence of TGF-beta1. Hence, our data suggested elevated concentration of serum TGF-beta1 in loss of NK cytotoxicity in superficial TCC patients, implicating altered innate immunity may correlate with the incidence of TCC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lin CT,Yu MT,Li C,Ho YC,Shen CH,Liu DW,Chang DC,Wu SFdoi
10.1016/j.canlet.2009.09.019subject
Has Abstractpub_date
2010-05-01 00:00:00pages
39-45issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00618-1journal_volume
291pub_type
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