Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats.

abstract：:The retinoblastoma (Rb) gene is associated with the pathogenesis of several types of human cancer, including retinoblastoma, osteosarcoma, soft tissue sarcomas, and lung, breast and bladder carcinomas. Loss of heterozygosity is a common mode in allelic inactivation of Rb and other tumor-suppressor genes. We investigat...

journal_title：Cancer letters

authors： Linardopoulos S,Gonos ES,Spandidos DA

更新日期：1993-07-30 00:00:00

abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...

journal_title：Cancer letters

authors： Lin LC,Gao AC,Lai CH,Hsieh JT,Lin H

更新日期：2017-04-10 00:00:00

abstract：:Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...

journal_title：Cancer letters

authors： Braginskaja OV,Lazarev VV,Polsachev VI,Rubin LB,Stoskii VE

更新日期：1993-04-30 00:00:00

abstract：:Tumor-associated mesenchymal stem cells (MSCs) play a critical role in the growth and metastasis of hepatocellular carcinoma (HCC). However, the mechanism underlying the crosstalk between MSCs and HCC cells is not completely understood. Here, HCC cells were treated with or without conditioned medium of MSCs (CM-MSC), ...

journal_title：Cancer letters

authors： Wang W,Wang Q,Huang DB,Sun QK,Wu SS,Zhao YJ,Jia W,Hu DS,He YF

更新日期：2021-01-17 00:00:00

abstract：:Chromosomal band 6q27 is believed to contain a tumor suppressor gene important in the development of several cancer types, including ovarian cancer. However, repeated efforts to identify a tumor suppressor gene in this region have been unsuccessful. Because homozygous deletions have been useful in the positional cloni...

journal_title：Cancer letters

authors： Lin H,Morin PJ

更新日期：2001-11-08 00:00:00

abstract：:The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...

journal_title：Cancer letters

authors： Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

更新日期：2010-02-01 00:00:00

abstract：:Rafoxanide is used in veterinary medicine for the treatment of fascioliasis. We previously repositioned the drug as the inhibitor of B-Raf V600E, but its anti-tumor effect in human cancer has never been reported. In this study, we investigated the effects of rafoxanide in multiple myeloma (MM) in vitro and in vivo. We...

journal_title：Cancer letters

authors： Xiao W,Xu Z,Chang S,Li B,Yu D,Wu H,Xie Y,Wang Y,Xie B,Sun X,Kong Y,Lan X,Bu W,Chen G,Gao L,Wu X,Shi J,Zhu W

更新日期：2019-03-01 00:00:00

abstract：:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...

journal_title：Cancer letters

authors： Jackson KM,DeLeon M,Verret CR,Harris WB

更新日期：2002-04-25 00:00:00

abstract：:Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

journal_title：Cancer letters

authors： Dipple A,Schultz E

更新日期：1979-07-01 00:00:00

abstract：:The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...

journal_title：Cancer letters

authors： Ben-Hur E,Rosenthal I

更新日期：1986-03-01 00:00:00

abstract：:cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examin...

journal_title：Cancer letters

authors： Tanimoto T,Tsuda H,Imazeki N,Ohno Y,Imoto I,Inazawa J,Matsubara O

更新日期：2005-06-16 00:00:00

abstract：:We investigated the molecular mechanisms involved in the anti-proliferative activity exerted by conjugated linoleic acid (CLA) on the estrogen unresponsive MDA-MB-231 human breast cancer cell line. The effects on cell proliferation, cell cycle progression and induction of apoptosis were examined. CLA caused the reduct...

journal_title：Cancer letters

authors： Miglietta A,Bozzo F,Bocca C,Gabriel L,Trombetta A,Belotti S,Canuto RA

更新日期：2006-03-28 00:00:00

abstract：:The influence of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a mutagen in chlorinated water, on cell proliferation and lipid peroxidation in the glandular stomach mucosa was investigated in male 4-week-old Wistar rats. Animals were given 50 p.p.m., 25 p.p.m., 12.5 p.p.m., 6.25 p.p.m. or 0 p.p.m. of MX soluti...

journal_title：Cancer letters

authors： Nishikawa A,Kinae N,Furukawa F,Mitsui M,Enami T,Hasegawa T,Takahashi M

更新日期：1994-10-14 00:00:00

abstract：:Telomerase, a critical enzyme responsible for continuous cell growth, is repressed in most somatic cells except proliferating progenitor cells and activated lymphocytes, and activated in approximately 85% of human cancer tissues. Telomerase activity is a useful cancer-cell detecting marker in some types of cancers in ...

journal_title：Cancer letters

authors： Hiyama E,Hiyama K

更新日期：2003-05-15 00:00:00

abstract：:Indomethacin is a non-steroidal anti-inflammatory agent that inhibits prostaglandin synthesis. Administration of indomethacin, in doses which were non-toxic to normal BALB/c mice, to mice bearing the BCL1 leukemia resulted in increased mortality of these animals. This effect was only observed if the indomethacin was a...

journal_title：Cancer letters

authors： Hart DA

更新日期：1984-06-01 00:00:00

abstract：:Sulfasalazine (SSZ) is an anti-inflammatory drug that has been demonstrated to induce apoptosis and tumor regression through inhibition of plasma membrane cystine transporter xc(-). Cysteine is a rate-limiting precursor for intracellular glutathione (GSH) synthesis, which is vital for compound detoxification and maint...

journal_title：Cancer letters

authors： Ma MZ,Chen G,Wang P,Lu WH,Zhu CF,Song M,Yang J,Wen S,Xu RH,Hu Y,Huang P

更新日期：2015-11-01 00:00:00

abstract：:In spite of much effort, no good markers have yet been found for predicting prognosis or response to therapy in advanced head and neck squamous cell carcinoma (HNSCCs) patients. beta-catenin, a protein involved in the cytoskeleton, cell-cell adhesion and gene transcription, is a factor associated with tumour progressi...

journal_title：Cancer letters

authors： Rodriguez-Pinilla M,Rodriguez-Peralto JL,Hitt R,Sanchez JJ,Sanchez-Verde L,Alameda F,Ballestin C,Sanchez-Cespedes M

更新日期：2005-12-08 00:00:00

abstract：:Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacological inhibition of Ak...

journal_title：Cancer letters

authors： Gao F,Alwhaibi A,Sabbineni H,Verma A,Eldahshan W,Somanath PR

更新日期：2017-08-28 00:00:00

abstract：:This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mouse prostates due to ...

journal_title：Cancer letters

authors： Nikhil K,Chang L,Viccaro K,Jacobsen M,McGuire C,Satapathy SR,Tandiary M,Broman MM,Cresswell G,He YJ,Sandusky GE,Ratliff TL,Chowdhury D,Shah K

更新日期：2019-04-28 00:00:00

abstract：:Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various ...

journal_title：Cancer letters

authors： Horiuchi K,Morioka H,Nishimoto K,Suzuki Y,Susa M,Nakayama R,Kawai A,Sonobe H,Takaishi H,Ozaki T,Yabe H,Umezawa K,Toyama Y

更新日期：2008-12-18 00:00:00

abstract：:Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...

journal_title：Cancer letters

authors： Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DS

更新日期：2014-01-28 00:00:00

abstract：:While the vast majority of cancers are believed to occur sporadically, most forms of cancer, both adult and paediatric, have a hereditary equivalent. In the case of adult malignancies, these include hereditary breast and ovarian cancer and syndromes such as the multiple endocrine neoplasias types 1 and 2 characterised...

journal_title：Cancer letters

authors： Marsh D,Zori R

更新日期：2002-07-26 00:00:00

abstract：:alpha-Toxin (alpha-hemolysin) of Staphylococcus aureus is a pore-forming bacterial toxin which after caveolin-1-dependent assembly induces apoptosis in eukaryotic cells. We investigated if a sub-toxic concentration of staphylococcal alpha-toxin could enhance cisplatin-induced apoptosis and overcome acquired cisplatin-...

journal_title：Cancer letters

authors： Johansson D,Johansson A,Behnam-Motlagh P

更新日期：2008-06-28 00:00:00

abstract：:Three series of monoacyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C4 to C10, were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol-13-ace...

journal_title：Cancer letters

authors： Colombo D,Compostella F,Ronchetti F,Scala A,Toma L,Mukainaka T,Nagatsu A,Konoshima T,Tokuda H,Nishino H

更新日期：1999-08-23 00:00:00

abstract：:Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non-coding RNAs (ln...

journal_title：Cancer letters

authors： Xi J,Sun Q,Ma L,Kang J

更新日期：2018-04-10 00:00:00

abstract：:Melanoma antigen A6 (MAGEA6)/TRIM28 complex is a cancer-specific ubiquitin ligase, which degradates tumor suppressor protein AMP-activated protein kinase (AMPK). We show that MAGEA6 is uniquely expressed in human glioma tissues and cells, which is correlated with AMPKα1 downregulation. It is yet absent in normal brain...

journal_title：Cancer letters

authors： Pan SJ,Ren J,Jiang H,Liu W,Hu LY,Pan YX,Sun B,Sun QF,Bian LG

更新日期：2018-01-01 00:00:00

abstract：:Selenium-dependent (Se-GSH-Px), selenium-independent (non-Se-GSH-Px) glutathione peroxidase and glutathione reductase (GSSG-Rx) activities have been determined in cancerous and non-cancerous human adult kidney. Large inter-individual variation in the activities of all enzymes tested were found in both tumour and non-t...

journal_title：Cancer letters

authors： Di Ilio C,Sacchetta P,Angelucci S,Zezza A,Tenaglia R,Aceto A

更新日期：1995-05-04 00:00:00

abstract：:Previous studies had established that transforming growth factor-beta1 (TGF-beta1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial...

journal_title：Cancer letters

authors： Lin CT,Yu MT,Li C,Ho YC,Shen CH,Liu DW,Chang DC,Wu SF

更新日期：2010-05-01 00:00:00

abstract：:Paclitaxel (Taxol) is currently used as the front-line chemotherapeutic drug for many types of human cancers. However, the emergence of drug resistance has been a major obstacle to the effective treatment of cancers in clinical settings. The transcription factor Forkhead box protein C2 (FOXC2) was recently demonstrate...

journal_title：Cancer letters

authors： Zhou Z,Zhang L,Xie B,Wang X,Yang X,Ding N,Zhang J,Liu Q,Tan G,Feng D,Sun LQ

更新日期：2015-07-28 00:00:00

abstract：:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...

journal_title：Cancer letters

authors： Lawson TA

更新日期：1990-08-01 00:00:00