Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.

abstract：:Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have emerged to combat this deadly cancer, the 5-year survival rate has plateaued over the past four decades. Therapeutic progress has been notably poo...

journal_title：Cancer letters

authors： Zhao J,Dean DC,Hornicek FJ,Yu X,Duan Z

更新日期：2020-04-01 00:00:00

abstract：:Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...

journal_title：Cancer letters

authors： Panani AD,Roussos C

更新日期：2006-04-08 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in Southern China and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor prognosis. The emergence of single-cell sequencing represents a powerful tool to resolve tumor heterogeneity and delineate the complex communicat...

journal_title：Cancer letters

authors： Zhao J,Guo C,Xiong F,Yu J,Ge J,Wang H,Liao Q,Zhou Y,Gong Q,Xiang B,Zhou M,Li X,Li G,Xiong W,Fang J,Zeng Z

更新日期：2020-05-01 00:00:00

abstract：:Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially...

journal_title：Cancer letters

authors： Dou R,Deng Y,Huang L,Fu S,Tan S,Wang L,Lian L,Fang L,Fan X,Jin G,Liu H,Wang J

更新日期：2013-08-09 00:00:00

abstract：:Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene located on chromosome 22...

journal_title：Cancer letters

authors： Manda R,Kohno T,Hamada K,Takenoshita S,Kuwano H,Yokota J

更新日期：2000-05-29 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...

journal_title：Cancer letters

authors： Plesnicar S,Kuszynski C,Patil KD

更新日期：1982-03-01 00:00:00

abstract：:Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...

journal_title：Cancer letters

authors： Liang C,Qin Y,Zhang B,Ji S,Shi S,Xu W,Liu J,Xiang J,Liang D,Hu Q,Ni Q,Yu X,Xu J

更新日期：2017-03-01 00:00:00

abstract：:The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....

journal_title：Cancer letters

authors： Han Y,Li H,Guan Y,Huang J

更新日期：2016-09-01 00:00:00

abstract：:The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a...

journal_title：Cancer letters

authors： Colella R,Goodwyn E,Gopal P

更新日期：2002-11-28 00:00:00

abstract：:The cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-te...

journal_title：Cancer letters

authors： Xu M,Dashwood RH

更新日期：1999-09-01 00:00:00

abstract：:The anti-carcinogenic activity of dietary fruit and vegetables observed in several epidemiological and experimental animal studies is likely to be an effect of the combined exposure to a large number of substances acting together. This is plausible, as these compounds are present simultaneously in a diet containing ve...

journal_title：Cancer letters

authors： Vang O,Rasmussen BF,Andersen O

更新日期：1997-03-19 00:00:00

abstract：:Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained, neural progenitor...

journal_title：Cancer letters

authors： Tech K,Deshmukh M,Gershon TR

更新日期：2015-01-28 00:00:00

abstract：:Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...

journal_title：Cancer letters

authors： Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DN

更新日期：1996-12-20 00:00:00

abstract：:We evaluated the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of neuroblastoma cells to cisplatin. Two cell lines, one derived from SH-SY5Y (SY5Y-TB8) and the other from SK-N-AS (AS-TB8), transfected with a TrkB plasmid were generated, and used to assess the effects of activatio...

journal_title：Cancer letters

authors： Jaboin J,Hong A,Kim CJ,Thiele CJ

更新日期：2003-04-10 00:00:00

abstract：:Rats bearing mammary carcinomas induced by N-nitroso-N-methylurea (NMU) were subjected to either no treatment (C), to ovariectomy (O), to continuous ketoconazole dosing at 400 ppm into the diet (K) or to both ovariectomy and ketoconazole dosing (O + K). In both C and K groups survival over the experimental period of 1...

journal_title：Cancer letters

authors： van Cauteren H,van den Berghe J,Hérin V,de Coster R,Marsboom R

更新日期：1984-09-01 00:00:00

abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...

journal_title：Cancer letters

authors： De Preter K,Vandesompele J,Heimann P,Kockx MM,Van Gele M,Hoebeeck J,De Smet E,Demarche M,Laureys G,Van Roy N,De Paepe A,Speleman F

更新日期：2003-07-18 00:00:00

abstract：:The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...

journal_title：Cancer letters

authors： Marczylo T,Ioannides C

更新日期：1998-05-15 00:00:00

abstract：:Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

journal_title：Cancer letters

authors： Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

更新日期：2010-12-01 00:00:00

abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...

journal_title：Cancer letters

authors： Lin LC,Gao AC,Lai CH,Hsieh JT,Lin H

更新日期：2017-04-10 00:00:00

abstract：:The dynamic changes of chicken erythrocyte membranes induced by a series of N-methyl-N'-aryl-N-nitrosoureas (I X) were investigated in comparison with those of N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by electron spin resonance spectroscopy. Both I X and MNNG increased the intensity...

journal_title：Cancer letters

authors： Yano K,Sonoda M,Sakagishi Y

更新日期：1985-04-01 00:00:00

abstract：:Loss of FHIT expression and p53 mutations are critical events in the early stages of lung carcinogenesis. The restoration of Fhit function in FHIT-negative cancer cells has been reported to cause tumour suppression by inhibition of cell proliferation and/or activation of apoptotic pathways. However, the studies design...

journal_title：Cancer letters

authors： Cavazzoni A,Galetti M,Fumarola C,Alfieri RR,Roz L,Andriani F,Carbognani P,Rusca M,Sozzi G,Petronini PG

更新日期：2007-02-08 00:00:00

abstract：:In the present study, Tbx3, a member of the T-box family of transcription factors, was identified as an up-regulated gene by mRNA differential display in the regression (apoptosis) stage after uracil-induction of papillomatosis in the rat urinary bladder. Immunohistochemical analysis revealed that apoptosis cells are ...

journal_title：Cancer letters

authors： Ito A,Asamoto M,Hokaiwado N,Takahashi S,Shirai T

更新日期：2005-02-28 00:00:00

abstract：:The mitochondrial genetic system is indispensable for the biosynthesis of the enzyme complexes involved in aerobic energy generation. Tetracyclines inhibit the expression of only the mitochondrial genes because they specifically block mitochondrial protein synthesis. A salient feature is that this inhibition occurs at...

journal_title：Cancer letters

authors： Kroon AM,Dontje BH,Holtrop M,Van den Bogert C

更新日期：1984-11-01 00:00:00

abstract：:The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that these expectations remain unfulfilled. Mutations in BRCA1 and BRCA2 ...

journal_title：Cancer letters

authors： Schwab M,Claas A,Savelyeva L

更新日期：2002-01-10 00:00:00

abstract：:Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...

journal_title：Cancer letters

authors： Horie S,Chen R,Li L,Mori S,Kodama T

更新日期：2013-10-10 00:00:00

abstract：:Electron microscopic studies were made on an in vitro cultured cell line obtained from the FCB transplantable murine bladder tumour. The cells exhibited a loss of differentiation compared with solid tumour and the presence of C-type virus particles, many in the process of budding. The possible relation of this virus t...

journal_title：Cancer letters

authors： Flaks A

更新日期：1977-07-01 00:00:00

abstract：:Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

journal_title：Cancer letters

authors： Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

更新日期：2009-02-18 00:00:00

abstract：:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

journal_title：Cancer letters

authors： Bybee A,Styles JA,Beck SL,Blackburn D

更新日期：1990-07-16 00:00:00

abstract：:A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor c...

journal_title：Cancer letters

authors： Walaszek Z,Hanausek-Walaszek M,Schumm DE,Webb TE

更新日期：1983-10-01 00:00:00