Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma.

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...

journal_title：Cancer letters

authors： Baljer BC,Kolhe S,Chan CD,Nicoli F,Ghanbasha A,Brookes MJ,Gamie Z,Ghosh KM,Beckingsale TB,Saleh DB,Ragbir M,Gerrand CH,Jeys L,Knight JC,Petrides G,Rankin KS

更新日期：2020-07-28 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...

journal_title：Cancer letters

authors： Tiwari AK,Crawford SE,Radosevich A,Wali RK,Stypula Y,Kunte DP,Mutyal N,Ruderman S,Gomes A,Cornwell ML,De La Cruz M,Brasky J,Gibson TP,Backman V,Roy HK

更新日期：2011-07-28 00:00:00

abstract：:5-fluorouracil (5-FU) is widely used in chemotherapy for colorectal cancer (CRC), but a high rate of chemoresistance reduces its effectiveness in clinical treatment. We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW620/5-FU and HCT-8/5-...

journal_title：Cancer letters

authors： Liu C,Zhao Y,Wang J,Yang Y,Zhang Y,Qu X,Peng S,Yao Z,Zhao S,He B,Mi Q,Zhu Y,Liu X,Zou J,Zhang X,Du Q

更新日期：2020-02-01 00:00:00

abstract：:C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L...

journal_title：Cancer letters

authors： Petersen TR,Bregenholta S,Pedersen LO,Nissen MH,Claesson MH

更新日期：1999-04-01 00:00:00

abstract：:In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...

journal_title：Cancer letters

authors： Baghdiguian S,Boudier JA,Boudier JL,Fantini J

更新日期：1993-12-20 00:00:00

abstract：:We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

journal_title：Cancer letters

authors： Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

更新日期：2011-07-28 00:00:00

abstract：:FHIT is a tumour suppressor gene which is frequently inactivated in different types of cancer. Both genetic (mutations, deletions, chromosomal rearrangements) and epigenetic (aberrant methylation of the 5'CpG island) alterations of the FHIT gene have been reported in various malignancies. Yet little is known about the...

journal_title：Cancer letters

authors： Kvasha S,Gordiyuk V,Kondratov A,Ugryn D,Zgonnyk YM,Rynditch AV,Vozianov AF

更新日期：2008-07-08 00:00:00

abstract：:Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...

journal_title：Cancer letters

authors： Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DN

更新日期：1996-12-20 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...

journal_title：Cancer letters

authors： To-Figueras J,Gené M,Gómez-Catalán J,Piqué E,Borrego N,Corbella J

更新日期：2001-11-28 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

journal_title：Cancer letters

authors： Shen C,Yang C,Xia B,You M

更新日期：2021-03-01 00:00:00

abstract：:The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the ef...

journal_title：Cancer letters

authors： Roseng LE,Rivedal E

更新日期：1993-08-16 00:00:00

abstract：:The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...

journal_title：Cancer letters

authors： Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

更新日期：2010-02-01 00:00:00

abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...

journal_title：Cancer letters

authors： Li CJ,Chu CY,Huang LH,Wang MH,Sheu LF,Yeh JI,Hsu HY

更新日期：2012-06-28 00:00:00

abstract：:Endometrial cancer is one of the most common gynecologic malignancies and many factors influence in its growth and development. As in many other types of cancer, prostaglandin E(2) (PGE(2)) is thought to be an accelerator of cell proliferation and endometrial cancer progression. In this study, we examined the effect o...

journal_title：Cancer letters

authors： Takahashi T,Ogawa H,Izumi K,Uehara H

更新日期：2011-07-01 00:00:00

abstract：:Effects of the green tea catechins (GTCs) on the late promotion or progression stage of mammary gland carcinogenesis were examined in female Sprague-Dawley (SD) rats pretreated with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 84 7-week-old rats received a 50 mg/kg body weight intra-gastric dose of DMBA, and star...

journal_title：Cancer letters

authors： Hirose M,Mizoguchi Y,Yaono M,Tanaka H,Yamaguchi T,Shirai T

更新日期：1997-01-30 00:00:00

abstract：:The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosusp...

journal_title：Cancer letters

authors： Zheng D,Wang Y,Zhang D,Liu Z,Duan C,Jia L,Wang F,Liu Y,Liu G,Hao L,Zhang Q

更新日期：2011-08-28 00:00:00

abstract：:Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm2) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosis factor-related ap...

journal_title：Cancer letters

authors： Jung PY,Ryu H,Rhee KJ,Hwang S,Lee CG,Gwon SY,Kim J,Kim J,Yoo BS,Baik SK,Bae KS,Eom YW

更新日期：2019-01-01 00:00:00

abstract：:Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...

journal_title：Cancer letters

authors： Yoshimoto M,Tsutsumi M,Iki K,Sasaki Y,Tsujiuchi T,Sugimura T,Wakabayashi K,Konishi Y

更新日期：1999-09-01 00:00:00

abstract：:The effect of dietary intake of an extract of the spice plant Rosmarinus officinalis L. on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and on the in vivo formation of mammary DMBA-DNA adducts was evaluated. Supplementation of a semi-purified diet with 1.0% (by wt.) rosemary extract resulted in ...

journal_title：Cancer letters

authors： Singletary KW,Nelshoppen JM

更新日期：1991-11-01 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...

journal_title：Cancer letters

authors： Gournay M,Paineau M,Archambeau J,Pedeux R

更新日期：2019-04-10 00:00:00

abstract：:The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

journal_title：Cancer letters

authors： Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

更新日期：1994-08-15 00:00:00

abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...

journal_title：Cancer letters

authors： Gadi VK

更新日期：2009-04-08 00:00:00

abstract：:In vitro and pre-clinical studies have suggested that addition of the diet-derived agent curcumin may provide a suitable adjunct to enhance efficacy of chemotherapy in models of colorectal cancer. However, the majority of evidence for this currently derives from established cell lines. Here, we utilised patient-derive...

journal_title：Cancer letters

authors： James MI,Iwuji C,Irving G,Karmokar A,Higgins JA,Griffin-Teal N,Thomas A,Greaves P,Cai H,Patel SR,Morgan B,Dennison A,Metcalfe M,Garcea G,Lloyd DM,Berry DP,Steward WP,Howells LM,Brown K

更新日期：2015-08-10 00:00:00

abstract：:We evaluated the influence of age and sex on rectal cell proliferation of 69 hospital controls and 66 patients with colorectal adenomas, by means of incubation of rectal biopsies with tritiated thymidine and autoradiography. In particular, we evaluated the labeling frequency in the upper 40% of rectal crypts (0 h), ac...

journal_title：Cancer letters

authors： Paganelli GM,Santucci R,Biasco G,Miglioli M,Barbara L

更新日期：1990-09-01 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...

journal_title：Cancer letters

authors： He Z,Wu J,Dang H,Lin H,Zheng H,Zhong D

更新日期：2011-04-28 00:00:00

abstract：:Neuroblastoma is the most common extra-cranial solid tumor in children. Despite advances in the treatment of childhood cancer, outcomes for children with advanced-stage neuroblastoma remain poor. Here we reported that 2-methoxyestradiol (2-ME) inhibited the proliferation and induced apoptosis in human neuroblastoma SK...

journal_title：Cancer letters

authors： Zhang Q,Ma Y,Cheng YF,Li WJ,Zhang Z,Chen SY

更新日期：2011-12-27 00:00:00